The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment
Mesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional differentiation potential and strong immunomodulatory capacity. MSCs have been widely used in the treatment of injured, inflammatory, and immune-related diseases. Resting MSCs lack differentiation and immunomodulatory abi...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1074863/full |
| _version_ | 1828041179763048448 |
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| author | Weiqiang Li Weiqiang Li Qianqian Liu Jinchao Shi Xiang Xu Xiang Xu Jinyi Xu |
| author_facet | Weiqiang Li Weiqiang Li Qianqian Liu Jinchao Shi Xiang Xu Xiang Xu Jinyi Xu |
| author_sort | Weiqiang Li |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional differentiation potential and strong immunomodulatory capacity. MSCs have been widely used in the treatment of injured, inflammatory, and immune-related diseases. Resting MSCs lack differentiation and immunomodulatory ability. Instead, they rely on microenvironmental factors to: 1) stimulate and regulate their expression of specific cell growth factors, chemokines, immunomodulatory factors, or receptors; or 2) direct their differentiation into specific tissue cells, which ultimately perform tissue regeneration and repair and immunomodulatory functions. Tumor necrosis factor (TNF)-α is central to the creation of an inflammatory microenvironment. TNF-α regulates the fate and functional reprogramming of MSCs, either alone or in combination with a variety of other inflammatory factors. TNF-α can exert opposing effects on MSCs, from inducing MSC apoptosis to enhancing their anti-tumor capacity. In addition, the immunomodulation and osteogenic differentiation capacities of MSCs, as well as their exosome or microvesicle components vary significantly with TNF-α stimulating concentration, time of administration, or its use in combination with or without other factors. Therefore, this review discusses the impact of TNF-α on the fate and functional reprogramming of MSCs in the inflammatory microenvironment, to provide new directions for improving the immunomodulatory and tissue repair functions of MSCs and enhance their therapeutic potential. |
| first_indexed | 2024-04-10T17:06:27Z |
| format | Article |
| id | doaj.art-a20946660bc6465ea63c5bd67ec27149 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T17:06:27Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a20946660bc6465ea63c5bd67ec271492023-02-06T04:32:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.10748631074863The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironmentWeiqiang Li0Weiqiang Li1Qianqian Liu2Jinchao Shi3Xiang Xu4Xiang Xu5Jinyi Xu6Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Research and Development, Ankerui (Shanxi) Biological Cell Co., Ltd., Shanxi, ChinaDepartment of Research and Development, Ankerui (Shanxi) Biological Cell Co., Ltd., Shanxi, ChinaDepartment of Research and Development, Ankerui (Shanxi) Biological Cell Co., Ltd., Shanxi, ChinaDepartment of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Army Medical University, Chongqing, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaMesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional differentiation potential and strong immunomodulatory capacity. MSCs have been widely used in the treatment of injured, inflammatory, and immune-related diseases. Resting MSCs lack differentiation and immunomodulatory ability. Instead, they rely on microenvironmental factors to: 1) stimulate and regulate their expression of specific cell growth factors, chemokines, immunomodulatory factors, or receptors; or 2) direct their differentiation into specific tissue cells, which ultimately perform tissue regeneration and repair and immunomodulatory functions. Tumor necrosis factor (TNF)-α is central to the creation of an inflammatory microenvironment. TNF-α regulates the fate and functional reprogramming of MSCs, either alone or in combination with a variety of other inflammatory factors. TNF-α can exert opposing effects on MSCs, from inducing MSC apoptosis to enhancing their anti-tumor capacity. In addition, the immunomodulation and osteogenic differentiation capacities of MSCs, as well as their exosome or microvesicle components vary significantly with TNF-α stimulating concentration, time of administration, or its use in combination with or without other factors. Therefore, this review discusses the impact of TNF-α on the fate and functional reprogramming of MSCs in the inflammatory microenvironment, to provide new directions for improving the immunomodulatory and tissue repair functions of MSCs and enhance their therapeutic potential.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1074863/fullmesenchymal stem cellsTNF-αexosomal microvesiclesimmunomodulationtissue regeneration and repair |
| spellingShingle | Weiqiang Li Weiqiang Li Qianqian Liu Jinchao Shi Xiang Xu Xiang Xu Jinyi Xu The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment Frontiers in Immunology mesenchymal stem cells TNF-α exosomal microvesicles immunomodulation tissue regeneration and repair |
| title | The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment |
| title_full | The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment |
| title_fullStr | The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment |
| title_full_unstemmed | The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment |
| title_short | The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment |
| title_sort | role of tnf α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment |
| topic | mesenchymal stem cells TNF-α exosomal microvesicles immunomodulation tissue regeneration and repair |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1074863/full |
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