The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment

Mesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional differentiation potential and strong immunomodulatory capacity. MSCs have been widely used in the treatment of injured, inflammatory, and immune-related diseases. Resting MSCs lack differentiation and immunomodulatory abi...

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Main Authors: Weiqiang Li, Qianqian Liu, Jinchao Shi, Xiang Xu, Jinyi Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1074863/full
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author Weiqiang Li
Weiqiang Li
Qianqian Liu
Jinchao Shi
Xiang Xu
Xiang Xu
Jinyi Xu
author_facet Weiqiang Li
Weiqiang Li
Qianqian Liu
Jinchao Shi
Xiang Xu
Xiang Xu
Jinyi Xu
author_sort Weiqiang Li
collection DOAJ
description Mesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional differentiation potential and strong immunomodulatory capacity. MSCs have been widely used in the treatment of injured, inflammatory, and immune-related diseases. Resting MSCs lack differentiation and immunomodulatory ability. Instead, they rely on microenvironmental factors to: 1) stimulate and regulate their expression of specific cell growth factors, chemokines, immunomodulatory factors, or receptors; or 2) direct their differentiation into specific tissue cells, which ultimately perform tissue regeneration and repair and immunomodulatory functions. Tumor necrosis factor (TNF)-α is central to the creation of an inflammatory microenvironment. TNF-α regulates the fate and functional reprogramming of MSCs, either alone or in combination with a variety of other inflammatory factors. TNF-α can exert opposing effects on MSCs, from inducing MSC apoptosis to enhancing their anti-tumor capacity. In addition, the immunomodulation and osteogenic differentiation capacities of MSCs, as well as their exosome or microvesicle components vary significantly with TNF-α stimulating concentration, time of administration, or its use in combination with or without other factors. Therefore, this review discusses the impact of TNF-α on the fate and functional reprogramming of MSCs in the inflammatory microenvironment, to provide new directions for improving the immunomodulatory and tissue repair functions of MSCs and enhance their therapeutic potential.
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spelling doaj.art-a20946660bc6465ea63c5bd67ec271492023-02-06T04:32:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.10748631074863The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironmentWeiqiang Li0Weiqiang Li1Qianqian Liu2Jinchao Shi3Xiang Xu4Xiang Xu5Jinyi Xu6Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Research and Development, Ankerui (Shanxi) Biological Cell Co., Ltd., Shanxi, ChinaDepartment of Research and Development, Ankerui (Shanxi) Biological Cell Co., Ltd., Shanxi, ChinaDepartment of Research and Development, Ankerui (Shanxi) Biological Cell Co., Ltd., Shanxi, ChinaDepartment of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Army Medical University, Chongqing, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaMesenchymal stem cells (MSCs) are pluripotent stem cells with multidirectional differentiation potential and strong immunomodulatory capacity. MSCs have been widely used in the treatment of injured, inflammatory, and immune-related diseases. Resting MSCs lack differentiation and immunomodulatory ability. Instead, they rely on microenvironmental factors to: 1) stimulate and regulate their expression of specific cell growth factors, chemokines, immunomodulatory factors, or receptors; or 2) direct their differentiation into specific tissue cells, which ultimately perform tissue regeneration and repair and immunomodulatory functions. Tumor necrosis factor (TNF)-α is central to the creation of an inflammatory microenvironment. TNF-α regulates the fate and functional reprogramming of MSCs, either alone or in combination with a variety of other inflammatory factors. TNF-α can exert opposing effects on MSCs, from inducing MSC apoptosis to enhancing their anti-tumor capacity. In addition, the immunomodulation and osteogenic differentiation capacities of MSCs, as well as their exosome or microvesicle components vary significantly with TNF-α stimulating concentration, time of administration, or its use in combination with or without other factors. Therefore, this review discusses the impact of TNF-α on the fate and functional reprogramming of MSCs in the inflammatory microenvironment, to provide new directions for improving the immunomodulatory and tissue repair functions of MSCs and enhance their therapeutic potential.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1074863/fullmesenchymal stem cellsTNF-αexosomal microvesiclesimmunomodulationtissue regeneration and repair
spellingShingle Weiqiang Li
Weiqiang Li
Qianqian Liu
Jinchao Shi
Xiang Xu
Xiang Xu
Jinyi Xu
The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment
Frontiers in Immunology
mesenchymal stem cells
TNF-α
exosomal microvesicles
immunomodulation
tissue regeneration and repair
title The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment
title_full The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment
title_fullStr The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment
title_full_unstemmed The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment
title_short The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment
title_sort role of tnf α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment
topic mesenchymal stem cells
TNF-α
exosomal microvesicles
immunomodulation
tissue regeneration and repair
url https://www.frontiersin.org/articles/10.3389/fimmu.2023.1074863/full
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