A synthetic method to assay polycystin channel biophysics

A synthetic method to assay polycystin channel biophysics

Ion channels are biological transistors that control ionic flux across cell membranes to regulate electrical transmission and signal transduction. They are found in all biological membranes and their conductive state kinetics are frequently disrupted in human diseases. Organelle ion channels are amo...

Descrición completa

Detalles Bibliográficos
Main Authors:	Megan Larmore, Orhi Esarte Palomero, Neha Kamat, Paul G DeCaen
Formato:	Artigo
Idioma:	English
Publicado:	eLife Sciences Publications Ltd 2024-10-01
Series:	eLife
Subjects:	ion channels synthetic biology polycystins ADPKD PKD biophysics
Acceso en liña:	https://elifesciences.org/articles/98534

Títulos similares

The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus
por: Kotdaji Ha, et al.
Publicado: (2020-11-01)

The GPCR properties of polycystin-1- A new paradigm
por: Robin L. Maser, et al.
Publicado: (2022-11-01)

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium
por: Xiaowen Liu, et al.
Publicado: (2018-02-01)

A case of new familiar genetic variant of Autosomal Dominant Polycystic Kidney Disease -2: a case study
por: Tetiana eLitvinchuk, et al.
Publicado: (2015-10-01)

Polycystin-2 (TRPP2) regulates primary cilium length in LLC-PK1 renal epithelial cells
por: Noelia Scarinci, et al.
Publicado: (2022-10-01)

Is There a Functional Role of Mitochondrial Dysfunction in the Pathogenesis of ARPKD?
por: Max Christoph Liebau
Publicado: (2021-10-01)

Polycystin-2 Mediated Calcium Signalling in the <i>Dictyostelium</i> Model for Autosomal Dominant Polycystic Kidney Disease
por: Claire Y. Allan, et al.
Publicado: (2024-03-01)

Atypical calcium regulation of the PKD2-L1 polycystin ion channel
por: Paul G DeCaen, et al.
Publicado: (2016-06-01)

Autosomal dominant polycystic kidney disease: an update on epidemiological and molecular aspects
por: Everton F. Alves, et al.
Publicado: (2015-12-01)

A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation
por: Charles E MacKay, et al.
Publicado: (2022-03-01)

Polycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1)
por: Wendy A. Lea, et al.
Publicado: (2023-08-01)

The Mechanosensitive Pkd2 Channel Modulates the Recruitment of Myosin II and Actin to the Cytokinetic Contractile Ring
por: Pritha Chowdhury, et al.
Publicado: (2024-06-01)

A polycystin-type transient receptor potential (Trp) channel that is activated by ATP
por: David Traynor, et al.
Publicado: (2017-02-01)

The Gating of Polycystin Signaling Complex
por: PATRICK DELMAS
Publicado: (2004-01-01)

Kidney and cystic volume imaging for disease presentation and progression in the cat autosomal dominant polycystic kidney disease large animal model
por: Yoshihiko Yu, et al.
Publicado: (2019-07-01)

Cyst growth, polycystins, and primary cilia in autosomal dominant polycystic kidney disease
por: Seung Hun Lee, et al.
Publicado: (2014-06-01)

Autosomal Dominant Polycystic Kidney Desease Coexisting with Renal Dysplasia. First Case Described and Followed Since Prenatal Period
por: Carmen Truyols
Publicado: (2018-10-01)

Congenital solitary kidney in autosomal dominant polycystic kidney disease: Where do known genes end and the unknown begin?
por: Romina Bucci, et al.
Publicado: (2023-11-01)

Identification and Characterization of Novel Mutations in Chronic Kidney Disease (CKD) and Autosomal Dominant Polycystic Kidney Disease (ADPKD) in Saudi Subjects by Whole-Exome Sequencing
por: Othman R. Alzahrani, et al.
Publicado: (2022-11-01)

Gene Panel Analysis in a Large Cohort of Patients With Autosomal Dominant Polycystic Kidney Disease Allows the Identification of 80 Potentially Causative Novel Variants and the Characterization of a Complex Genetic Architecture in a Subset of Families
por: Vilma Mantovani, et al.
Publicado: (2020-05-01)

The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR
por: Mónica Roxo-Rosa, et al.
Publicado: (2015-11-01)

PKD1 deficiency induces Bronchiectasis in a porcine ADPKD model
por: Runming Wang, et al.
Publicado: (2022-10-01)

Nueva mutación asociada a poliquistosis renal autosómica dominante con efecto fundador localizada en la Alpujarra de Granada
por: Carmen García-Rabaneda, et al.
Publicado: (2020-09-01)

Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames
por: Lei Chen, et al.
Publicado: (2025-12-01)

Establishment of transgenic pigs overexpressing human PKD2-D511V mutant
por: Yuan Zhang, et al.
Publicado: (2022-11-01)

Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure
por: Charles E MacKay, et al.
Publicado: (2020-05-01)

Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance
por: Luis A Bezares-Calderón, et al.
Publicado: (2018-12-01)

OGM and WES identifies translocation breakpoints in PKD1 gene in an polycystic kidney patient and healthy baby delivered using PGT
por: Peiwen Xu, et al.
Publicado: (2023-11-01)

Exome sequencing of Saudi Arabian patients with ADPKD
por: Fahad A. Al-Muhanna, et al.
Publicado: (2019-01-01)

PKD2/polycystin-2 inhibits LPS-induced acute lung injury in vitro and in vivo by activating autophagy
por: Fan Pan, et al.
Publicado: (2023-05-01)

Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins
por: Tao Xu, et al.
Publicado: (2022-07-01)

Genetic analysis and counseling of ADPKD caused by novel heterozygous mutations of PKD1 in two Chinese families: Case report
por: Yanan Wang, et al.
Publicado: (2024-11-01)

Case Report: Autosomal dominant polycystic kidney disease and Wilms’ tumor in infancy and childhood
por: Doviltyte Zina, et al.
Publicado: (2024-03-01)

Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion
por: Elizabeth J. Wilk, et al.
Publicado: (2023-05-01)

Novel long-range regulatory mechanisms controlling PKD2 gene expression
por: Stéphanie Moisan, et al.
Publicado: (2018-07-01)

Aortic dissection is associated with reduced polycystin-1 expression, an abnormality that leads to increased ERK phosphorylation in vascular smooth muscle cells
por: J. Feng, et al.
Publicado: (2016-12-01)

Intracellular calcium release modulates polycystin-2 trafficking
por: Miyakawa Ayako, et al.
Publicado: (2013-02-01)

Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists
por: Shristi Pawnikar, et al.
Publicado: (2024-10-01)

Progression to kidney failure in ADPKD: the PROPKD score underestimates the risk assessed by the Mayo imaging classification
por: Daniela Maria Allmer, et al.
Publicado: (2024-11-01)

Genetics of Autosomal Recessive Polycystic Kidney Disease and Its Differential Diagnoses
por: Carsten Bergmann, et al.
Publicado: (2018-02-01)