Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies
Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glyc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/10/6/685 |
| _version_ | 1797531739699019776 |
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| author | Emmanuelle V. LeBlanc Youjin Kim Chantelle J. Capicciotti Che C. Colpitts |
| author_facet | Emmanuelle V. LeBlanc Youjin Kim Chantelle J. Capicciotti Che C. Colpitts |
| author_sort | Emmanuelle V. LeBlanc |
| collection | DOAJ |
| description | Chronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glycan-dependent interactions are crucial to many aspects of the highly complex HCV entry process, and also modulate immune evasion. This review provides an overview of the roles of viral and cellular glycans in HCV infection and highlights glycan-focused advances in the development of entry inhibitors and vaccines to effectively prevent HCV infection. |
| first_indexed | 2024-03-10T10:49:02Z |
| format | Article |
| id | doaj.art-a20a565a53a049feba5f1e0f660c4e9f |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T10:49:02Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-a20a565a53a049feba5f1e0f660c4e9f2023-11-21T22:22:52ZengMDPI AGPathogens2076-08172021-06-0110668510.3390/pathogens10060685Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative StrategiesEmmanuelle V. LeBlanc0Youjin Kim1Chantelle J. Capicciotti2Che C. Colpitts3Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, CanadaChronic hepatitis C virus (HCV) infections continue to be a major contributor to liver disease worldwide. HCV treatment has become highly effective, yet there are still no vaccines or prophylactic strategies available to prevent infection and allow effective management of the global HCV burden. Glycan-dependent interactions are crucial to many aspects of the highly complex HCV entry process, and also modulate immune evasion. This review provides an overview of the roles of viral and cellular glycans in HCV infection and highlights glycan-focused advances in the development of entry inhibitors and vaccines to effectively prevent HCV infection.https://www.mdpi.com/2076-0817/10/6/685hepatitis C virusviral entryglycansvaccinesprophylaxis |
| spellingShingle | Emmanuelle V. LeBlanc Youjin Kim Chantelle J. Capicciotti Che C. Colpitts Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies Pathogens hepatitis C virus viral entry glycans vaccines prophylaxis |
| title | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
| title_full | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
| title_fullStr | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
| title_full_unstemmed | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
| title_short | Hepatitis C Virus Glycan-Dependent Interactions and the Potential for Novel Preventative Strategies |
| title_sort | hepatitis c virus glycan dependent interactions and the potential for novel preventative strategies |
| topic | hepatitis C virus viral entry glycans vaccines prophylaxis |
| url | https://www.mdpi.com/2076-0817/10/6/685 |
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