Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats
Various drug delivery systems were developed using a modified form of gum ghatti. Modifying gum ghatti using thioglycolic acid improves its mucoadhesive property, and hence, it is a suitable approach for the fabrication and development of controlled drug delivery systems. In accordance with regulato...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/18/3836 |
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| author | Vivek Puri Ameya Sharma Pradeep Kumar Kamal Dua Kampanart Huanbutta Inderbir Singh Tanikan Sangnim |
| author_facet | Vivek Puri Ameya Sharma Pradeep Kumar Kamal Dua Kampanart Huanbutta Inderbir Singh Tanikan Sangnim |
| author_sort | Vivek Puri |
| collection | DOAJ |
| description | Various drug delivery systems were developed using a modified form of gum ghatti. Modifying gum ghatti using thioglycolic acid improves its mucoadhesive property, and hence, it is a suitable approach for the fabrication and development of controlled drug delivery systems. In accordance with regulatory guidelines, namely, the Organization for Economic Co-operation and Development’s (OECD) 423 guidelines, an acute oral dose toxicity study was performed to examine the toxicological effects of gum ghattiin an animal (Wistar rat) after a single oral dose administration of pure gum ghatti and thiolated gum ghatti. Orally administered pure and thiolated gum ghatti do not reveal any considerable change in the behavioral pattern, food intake, body weight, hematology, or clinical symptoms of treated animals. Furthermore, histopathological studies showed no pathological mutations in the vital organs of Wistar rats after the oral administration of single doses of both types of gumghatti (i.e., 300 mg/kg and 2000 mg/kg body weight). Whole blood clotting studies showed the low absorbance value of the modified gum (thiolated gum ghatti) in contrast to the pure gum and control, hence demonstrating its excellent clotting capability. The aforementioned toxicological study suggested that the oral administration of a single dose of pure and thiolated gum ghatti did not produce any toxicological effects in Wistar rats. Consequently, it could be a suitable and safe candidate for formulating various drug delivery systems. |
| first_indexed | 2024-03-09T22:45:41Z |
| format | Article |
| id | doaj.art-a20bf91837184ea2ab90e95092813d29 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T22:45:41Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-a20bf91837184ea2ab90e95092813d292023-11-23T18:30:52ZengMDPI AGPolymers2073-43602022-09-011418383610.3390/polym14183836Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in RatsVivek Puri0Ameya Sharma1Pradeep Kumar2Kamal Dua3Kampanart Huanbutta4Inderbir Singh5Tanikan Sangnim6Chitkara University School of Pharmacy, Chitkara University, Baddi 174103, Himachal Pradesh, IndiaChitkara University School of Pharmacy, Chitkara University, Baddi 174103, Himachal Pradesh, IndiaDepartment of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South AfricaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, AustraliaSchool of Pharmacy, Eastern Asia University, Thanyaburi 12110, Pathumthani, ThailandChitkara College of Pharmacy, Chitkara University, Patiala 140401, Punjab, IndiaFaculty of Pharmaceutical Sciences, Burapha University, Muang 20131, Chonburi, ThailandVarious drug delivery systems were developed using a modified form of gum ghatti. Modifying gum ghatti using thioglycolic acid improves its mucoadhesive property, and hence, it is a suitable approach for the fabrication and development of controlled drug delivery systems. In accordance with regulatory guidelines, namely, the Organization for Economic Co-operation and Development’s (OECD) 423 guidelines, an acute oral dose toxicity study was performed to examine the toxicological effects of gum ghattiin an animal (Wistar rat) after a single oral dose administration of pure gum ghatti and thiolated gum ghatti. Orally administered pure and thiolated gum ghatti do not reveal any considerable change in the behavioral pattern, food intake, body weight, hematology, or clinical symptoms of treated animals. Furthermore, histopathological studies showed no pathological mutations in the vital organs of Wistar rats after the oral administration of single doses of both types of gumghatti (i.e., 300 mg/kg and 2000 mg/kg body weight). Whole blood clotting studies showed the low absorbance value of the modified gum (thiolated gum ghatti) in contrast to the pure gum and control, hence demonstrating its excellent clotting capability. The aforementioned toxicological study suggested that the oral administration of a single dose of pure and thiolated gum ghatti did not produce any toxicological effects in Wistar rats. Consequently, it could be a suitable and safe candidate for formulating various drug delivery systems.https://www.mdpi.com/2073-4360/14/18/3836thiolated gum ghattioral toxicity studyblood clotting factorWistar rat |
| spellingShingle | Vivek Puri Ameya Sharma Pradeep Kumar Kamal Dua Kampanart Huanbutta Inderbir Singh Tanikan Sangnim Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats Polymers thiolated gum ghatti oral toxicity study blood clotting factor Wistar rat |
| title | Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats |
| title_full | Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats |
| title_fullStr | Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats |
| title_full_unstemmed | Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats |
| title_short | Assessment of Acute Oral Toxicity of Thiolated Gum Ghatti in Rats |
| title_sort | assessment of acute oral toxicity of thiolated gum ghatti in rats |
| topic | thiolated gum ghatti oral toxicity study blood clotting factor Wistar rat |
| url | https://www.mdpi.com/2073-4360/14/18/3836 |
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