Comparison of Effectiveness of Ropivacaine Infusion Regimens for Continuous Femoral Nerve Block for Recovery After Total Knee Arthroplasty: A Randomized Double-Blind Trial
Yujian Zhang,* Le Liu,* Liangyu Zheng, Jiali Chen, Lvdan Huang, Quanguang Wang, Kejian Shi Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence:...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-05-01
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| Series: | Journal of Pain Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/comparison-of-effectiveness-of-ropivacaine-infusion-regimens-for-conti-peer-reviewed-article-JPR |
| _version_ | 1818845723084455936 |
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| author | Zhang Y Liu L Zheng L Chen J Huang L Wang Q Shi K |
| author_facet | Zhang Y Liu L Zheng L Chen J Huang L Wang Q Shi K |
| author_sort | Zhang Y |
| collection | DOAJ |
| description | Yujian Zhang,* Le Liu,* Liangyu Zheng, Jiali Chen, Lvdan Huang, Quanguang Wang, Kejian Shi Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kejian Shi; Quanguang WangDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ChinaTel +86 13868889697; +86 13736935500Fax +86 57755578999+669697; +86 57755578999+655500Email wzshikejian@163.com; wangquanguang@163.comPurpose: Continuous femoral nerve block (cFNB) is effective for analgesia after total knee arthroplasty (TKA). However, it is not clear which low-dose regimen of ropivacaine infusion for cFNB provides adequate analgesia and enables rapid recovery. The aim of this study was to compare the effects of different cFNB regimens on rehabilitation of patients after TKA.Patients and Methods: Sixty patients scheduled for TKA were enrolled in this trial. After surgery, patients in the 0.1%, 0.15%, and 0.2% groups received infusion of 10 mL of 0.1%, 6.7 mL of 0.15%, and 5 mL of 0.2% ropivacaine per hour, respectively (n=20), at the dose of 10 mg/h for 48 h. The primary endpoint was time to readiness for discharge. The secondary endpoints were time to first walk, manual muscle testing (MMT) scores, numerical rating scale (NRS) scores at rest and movement, morphine consumption, rescue analgesia, and the incidence of adverse events.Results: The time to readiness for discharge and the time to first walk of the 0.1% group were significantly longer than that of the 0.15% and 0.2% groups. MMT scores of the 0.2% group at 18 h after surgery were significantly lower than those of the 0.1% group. MMT scores of the 0.2% group at 24 and 48 h after surgery were also significantly lower than those of the 0.1% and 0.15% groups. NRS scores at rest and at movement in the 0.1% group were significantly higher than those in the 0.15% and 0.2% groups.Conclusion: Patients administered the regimens of 0.15% and 0.2% ropivacaine infusion for cFNB were ready for discharge earlier than the 0.1% group after TKA, at the dose of 10 mg/h for 48 h. The regimen of 0.15% ropivacaine, which is associated with less quadriceps muscle strength weakness than 0.2%, is recommended for postoperative analgesia after TKA.Keywords: analgesia, ultrasound, regional anesthesia, quadriceps muscle strength |
| first_indexed | 2024-12-19T05:34:11Z |
| format | Article |
| id | doaj.art-a20c19f99a6f441cb934d51e4e8e176e |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-19T05:34:11Z |
| publishDate | 2020-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-a20c19f99a6f441cb934d51e4e8e176e2022-12-21T20:34:09ZengDove Medical PressJournal of Pain Research1178-70902020-05-01Volume 13997100553708Comparison of Effectiveness of Ropivacaine Infusion Regimens for Continuous Femoral Nerve Block for Recovery After Total Knee Arthroplasty: A Randomized Double-Blind TrialZhang YLiu LZheng LChen JHuang LWang QShi KYujian Zhang,* Le Liu,* Liangyu Zheng, Jiali Chen, Lvdan Huang, Quanguang Wang, Kejian Shi Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kejian Shi; Quanguang WangDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of ChinaTel +86 13868889697; +86 13736935500Fax +86 57755578999+669697; +86 57755578999+655500Email wzshikejian@163.com; wangquanguang@163.comPurpose: Continuous femoral nerve block (cFNB) is effective for analgesia after total knee arthroplasty (TKA). However, it is not clear which low-dose regimen of ropivacaine infusion for cFNB provides adequate analgesia and enables rapid recovery. The aim of this study was to compare the effects of different cFNB regimens on rehabilitation of patients after TKA.Patients and Methods: Sixty patients scheduled for TKA were enrolled in this trial. After surgery, patients in the 0.1%, 0.15%, and 0.2% groups received infusion of 10 mL of 0.1%, 6.7 mL of 0.15%, and 5 mL of 0.2% ropivacaine per hour, respectively (n=20), at the dose of 10 mg/h for 48 h. The primary endpoint was time to readiness for discharge. The secondary endpoints were time to first walk, manual muscle testing (MMT) scores, numerical rating scale (NRS) scores at rest and movement, morphine consumption, rescue analgesia, and the incidence of adverse events.Results: The time to readiness for discharge and the time to first walk of the 0.1% group were significantly longer than that of the 0.15% and 0.2% groups. MMT scores of the 0.2% group at 18 h after surgery were significantly lower than those of the 0.1% group. MMT scores of the 0.2% group at 24 and 48 h after surgery were also significantly lower than those of the 0.1% and 0.15% groups. NRS scores at rest and at movement in the 0.1% group were significantly higher than those in the 0.15% and 0.2% groups.Conclusion: Patients administered the regimens of 0.15% and 0.2% ropivacaine infusion for cFNB were ready for discharge earlier than the 0.1% group after TKA, at the dose of 10 mg/h for 48 h. The regimen of 0.15% ropivacaine, which is associated with less quadriceps muscle strength weakness than 0.2%, is recommended for postoperative analgesia after TKA.Keywords: analgesia, ultrasound, regional anesthesia, quadriceps muscle strengthhttps://www.dovepress.com/comparison-of-effectiveness-of-ropivacaine-infusion-regimens-for-conti-peer-reviewed-article-JPRanalgesiaultrasoundregional anesthesiaquadriceps muscle strength |
| spellingShingle | Zhang Y Liu L Zheng L Chen J Huang L Wang Q Shi K Comparison of Effectiveness of Ropivacaine Infusion Regimens for Continuous Femoral Nerve Block for Recovery After Total Knee Arthroplasty: A Randomized Double-Blind Trial Journal of Pain Research analgesia ultrasound regional anesthesia quadriceps muscle strength |
| title | Comparison of Effectiveness of Ropivacaine Infusion Regimens for Continuous Femoral Nerve Block for Recovery After Total Knee Arthroplasty: A Randomized Double-Blind Trial |
| title_full | Comparison of Effectiveness of Ropivacaine Infusion Regimens for Continuous Femoral Nerve Block for Recovery After Total Knee Arthroplasty: A Randomized Double-Blind Trial |
| title_fullStr | Comparison of Effectiveness of Ropivacaine Infusion Regimens for Continuous Femoral Nerve Block for Recovery After Total Knee Arthroplasty: A Randomized Double-Blind Trial |
| title_full_unstemmed | Comparison of Effectiveness of Ropivacaine Infusion Regimens for Continuous Femoral Nerve Block for Recovery After Total Knee Arthroplasty: A Randomized Double-Blind Trial |
| title_short | Comparison of Effectiveness of Ropivacaine Infusion Regimens for Continuous Femoral Nerve Block for Recovery After Total Knee Arthroplasty: A Randomized Double-Blind Trial |
| title_sort | comparison of effectiveness of ropivacaine infusion regimens for continuous femoral nerve block for recovery after total knee arthroplasty a randomized double blind trial |
| topic | analgesia ultrasound regional anesthesia quadriceps muscle strength |
| url | https://www.dovepress.com/comparison-of-effectiveness-of-ropivacaine-infusion-regimens-for-conti-peer-reviewed-article-JPR |
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