Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development
Endometriosis-related infertility describes a case of deteriorated fecundity when endometriosis is diagnosed. Numerous mechanisms have been proposed in an effort to delineate the multifaceted pathophysiology that induces impairment of reproductive dynamics in patients with endometriosis. In this cri...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/3/273 |
| _version_ | 1797542065868898304 |
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| author | Mara Simopoulou Anna Rapani Sokratis Grigoriadis Agni Pantou Petroula Tsioulou Evangelos Maziotis Despina Tzanakaki Olga Triantafyllidou Theodoros Kalampokas Charalampos Siristatidis Panagiotis Bakas Nikolaos Vlahos |
| author_facet | Mara Simopoulou Anna Rapani Sokratis Grigoriadis Agni Pantou Petroula Tsioulou Evangelos Maziotis Despina Tzanakaki Olga Triantafyllidou Theodoros Kalampokas Charalampos Siristatidis Panagiotis Bakas Nikolaos Vlahos |
| author_sort | Mara Simopoulou |
| collection | DOAJ |
| description | Endometriosis-related infertility describes a case of deteriorated fecundity when endometriosis is diagnosed. Numerous mechanisms have been proposed in an effort to delineate the multifaceted pathophysiology that induces impairment of reproductive dynamics in patients with endometriosis. In this critical analysis, authors present the plethora of molecular events that are entailed and elaborate on how they potentially impair the oocyte’s and embryo’s competence in patients with endometriosis. Reactive oxygen species, dysregulation of the immune system and cellular architectural disruption constitute the crucial mechanisms that detrimentally affect oocyte and embryo developmental potential. The molecular level impairment of the reproductive tissue is discussed, since differentiation, proliferation and apoptosis constitute focal regulatory cellular functions that appear severely compromised in cases of endometriosis. Mapping the precise molecular mechanisms entailed in endometriosis-related infertility may help delineate the complex nature of the disorder and bring us a step closer to a more personalized approach in understanding, diagnosing and managing endometriosis-related infertility. |
| first_indexed | 2024-03-10T13:24:23Z |
| format | Article |
| id | doaj.art-a20c8fff46ab4fcb89ebfb07841d9402 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T13:24:23Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-a20c8fff46ab4fcb89ebfb07841d94022023-11-21T09:46:27ZengMDPI AGBiomedicines2227-90592021-03-019327310.3390/biomedicines9030273Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo DevelopmentMara Simopoulou0Anna Rapani1Sokratis Grigoriadis2Agni Pantou3Petroula Tsioulou4Evangelos Maziotis5Despina Tzanakaki6Olga Triantafyllidou7Theodoros Kalampokas8Charalampos Siristatidis9Panagiotis Bakas10Nikolaos Vlahos11Laboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias, 11527 Athens, GreeceAssisted Reproduction Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, GreeceAssisted Reproduction Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, GreeceAssisted Reproduction Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, GreeceAssisted Reproduction Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, GreeceAssisted Reproduction Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, GreeceAssisted Reproduction Unit, Second Department of Obstetrics and Gynecology, Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, 76, Vasilisis Sofias Avenue, 11528 Athens, GreeceEndometriosis-related infertility describes a case of deteriorated fecundity when endometriosis is diagnosed. Numerous mechanisms have been proposed in an effort to delineate the multifaceted pathophysiology that induces impairment of reproductive dynamics in patients with endometriosis. In this critical analysis, authors present the plethora of molecular events that are entailed and elaborate on how they potentially impair the oocyte’s and embryo’s competence in patients with endometriosis. Reactive oxygen species, dysregulation of the immune system and cellular architectural disruption constitute the crucial mechanisms that detrimentally affect oocyte and embryo developmental potential. The molecular level impairment of the reproductive tissue is discussed, since differentiation, proliferation and apoptosis constitute focal regulatory cellular functions that appear severely compromised in cases of endometriosis. Mapping the precise molecular mechanisms entailed in endometriosis-related infertility may help delineate the complex nature of the disorder and bring us a step closer to a more personalized approach in understanding, diagnosing and managing endometriosis-related infertility.https://www.mdpi.com/2227-9059/9/3/273endometriosisinfertilityoocyteembryoquality |
| spellingShingle | Mara Simopoulou Anna Rapani Sokratis Grigoriadis Agni Pantou Petroula Tsioulou Evangelos Maziotis Despina Tzanakaki Olga Triantafyllidou Theodoros Kalampokas Charalampos Siristatidis Panagiotis Bakas Nikolaos Vlahos Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development Biomedicines endometriosis infertility oocyte embryo quality |
| title | Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development |
| title_full | Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development |
| title_fullStr | Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development |
| title_full_unstemmed | Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development |
| title_short | Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development |
| title_sort | getting to know endometriosis related infertility better a review on how endometriosis affects oocyte quality and embryo development |
| topic | endometriosis infertility oocyte embryo quality |
| url | https://www.mdpi.com/2227-9059/9/3/273 |
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