Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties
Abstract Mauritius Island possesses unique plant biodiversity with a potential reservoir of biologically active compounds of pharmacological interest. In the current study, we investigated Mauritius endemic plant families Asteraceae, Ebenaceae, Sapotaceae, and Erythroxylaceae, for anti-cancer proper...
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| Format: | Article |
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Nature Portfolio
2021-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-83461-0 |
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| author | Shahin Kauroo Joyce Govinden-Soulange V. Mala Ranghoo-Sanmukhiya Kathryn Miranda William E. Cotham Michael D. Walla Mitzi Nagarkatti Prakash Nagarkatti |
| author_facet | Shahin Kauroo Joyce Govinden-Soulange V. Mala Ranghoo-Sanmukhiya Kathryn Miranda William E. Cotham Michael D. Walla Mitzi Nagarkatti Prakash Nagarkatti |
| author_sort | Shahin Kauroo |
| collection | DOAJ |
| description | Abstract Mauritius Island possesses unique plant biodiversity with a potential reservoir of biologically active compounds of pharmacological interest. In the current study, we investigated Mauritius endemic plant families Asteraceae, Ebenaceae, Sapotaceae, and Erythroxylaceae, for anti-cancer properties on T cell lymphoma and B16F10 Melanoma cells and immunomodulatory properties on primary T and B cells. The cytotoxicity of methanolic plant extracts at 1, 10, 25 µg/ml was determined. The most active plant species were evaluated for their apoptosis-inducing effects. The immunomodulatory properties of the plants were also studied, and preliminary phytochemical screening of selected plants was done by LC–MS analysis. Psiadia lithospermifolia (Lam.) Cordem (Asteraceae) at 25 µg/ml was the most cytotoxic on both EL4 and B16 cells and triggered apoptosis by the death receptor pathway, and at least in part, by the mitochondrial pathway. Most plant species from Asteraceae, Ebenaceae, Erythroxylaceae, and Sapotaceae inhibited the proliferation of activated T and B cells, although some promoted T cell proliferation. LC–MS profile of Asteraceae plants showed the presence of terpenes, terpenoids, fatty acids, and phenolic. Flavonoids and phenolic acid were also detected from Ebenaceae and Sapotaceae plants. Together, our study demonstrated that Mauritius endemic flora exhibit potential anti-cancer and anti-inflammatory properties worthy of further in-depth studies. |
| first_indexed | 2024-12-19T03:55:17Z |
| format | Article |
| id | doaj.art-a20f2670b24c4c2f80c972f2b98d1cd7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T03:55:17Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a20f2670b24c4c2f80c972f2b98d1cd72022-12-21T20:36:50ZengNature PortfolioScientific Reports2045-23222021-02-0111111710.1038/s41598-021-83461-0Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory propertiesShahin Kauroo0Joyce Govinden-Soulange1V. Mala Ranghoo-Sanmukhiya2Kathryn Miranda3William E. Cotham4Michael D. Walla5Mitzi Nagarkatti6Prakash Nagarkatti7Faculty of Agriculture, University of MauritiusFaculty of Agriculture, University of MauritiusFaculty of Agriculture, University of MauritiusDepartment of Pathology, Microbiology & Immunology, School of Medicine, University of South CarolinaDepartment of Chemistry and Biochemistry, College of Arts and Science, University of South CarolinaDepartment of Chemistry and Biochemistry, College of Arts and Science, University of South CarolinaDepartment of Pathology, Microbiology & Immunology, School of Medicine, University of South CarolinaDepartment of Pathology, Microbiology & Immunology, School of Medicine, University of South CarolinaAbstract Mauritius Island possesses unique plant biodiversity with a potential reservoir of biologically active compounds of pharmacological interest. In the current study, we investigated Mauritius endemic plant families Asteraceae, Ebenaceae, Sapotaceae, and Erythroxylaceae, for anti-cancer properties on T cell lymphoma and B16F10 Melanoma cells and immunomodulatory properties on primary T and B cells. The cytotoxicity of methanolic plant extracts at 1, 10, 25 µg/ml was determined. The most active plant species were evaluated for their apoptosis-inducing effects. The immunomodulatory properties of the plants were also studied, and preliminary phytochemical screening of selected plants was done by LC–MS analysis. Psiadia lithospermifolia (Lam.) Cordem (Asteraceae) at 25 µg/ml was the most cytotoxic on both EL4 and B16 cells and triggered apoptosis by the death receptor pathway, and at least in part, by the mitochondrial pathway. Most plant species from Asteraceae, Ebenaceae, Erythroxylaceae, and Sapotaceae inhibited the proliferation of activated T and B cells, although some promoted T cell proliferation. LC–MS profile of Asteraceae plants showed the presence of terpenes, terpenoids, fatty acids, and phenolic. Flavonoids and phenolic acid were also detected from Ebenaceae and Sapotaceae plants. Together, our study demonstrated that Mauritius endemic flora exhibit potential anti-cancer and anti-inflammatory properties worthy of further in-depth studies.https://doi.org/10.1038/s41598-021-83461-0 |
| spellingShingle | Shahin Kauroo Joyce Govinden-Soulange V. Mala Ranghoo-Sanmukhiya Kathryn Miranda William E. Cotham Michael D. Walla Mitzi Nagarkatti Prakash Nagarkatti Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties Scientific Reports |
| title | Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties |
| title_full | Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties |
| title_fullStr | Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties |
| title_full_unstemmed | Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties |
| title_short | Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties |
| title_sort | extracts of select endemic plants from the republic of mauritius exhibiting anti cancer and immunomodulatory properties |
| url | https://doi.org/10.1038/s41598-021-83461-0 |
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