Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis
Abstract Echinococcosis is a zoonotic infection caused by cestode species of the genus Echinococcus, with limited treatment options. It is urgent to develop new anti-hydatid agent. In this paper, we reported anacardic acid (AA), a natural product isolated from the Brazilian cashew-nut shell liquid,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-01-01
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| Series: | Veterinary Research |
| Online Access: | http://link.springer.com/article/10.1186/s13567-019-0621-7 |
| _version_ | 1811319419917303808 |
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| author | Miaomiao Yuan Xiaoxia Song Wei Lv Qi Xin Li Wang Qi Gao Guochao Zhang Wenzhen Liao Sen Lian Tao Jing |
| author_facet | Miaomiao Yuan Xiaoxia Song Wei Lv Qi Xin Li Wang Qi Gao Guochao Zhang Wenzhen Liao Sen Lian Tao Jing |
| author_sort | Miaomiao Yuan |
| collection | DOAJ |
| description | Abstract Echinococcosis is a zoonotic infection caused by cestode species of the genus Echinococcus, with limited treatment options. It is urgent to develop new anti-hydatid agent. In this paper, we reported anacardic acid (AA), a natural product isolated from the Brazilian cashew-nut shell liquid, which presented a high activity against metacestodes of Echinococcus multilocularis (E. multilocularis) and Echinococcus granulosus sensu stricto (E. granulosus s.s.) in vitro and in vivo. AA exerted a better efficacy on E. granulosus s.s. protoscoleces and E. multilocularis metacestodes than that of albendazole (ABZ) and dihydroartemisinin (DHA) in vitro, and an inhibition on the growth of Echinococcus metacestode as effective as ABZ in vivo. Moreover, we also found that one of the mechanisms of AA against Echinococcus could be the suppression of angiogenesis on/in the metacestode mass through inhibiting vascular endothelial growth factor (VEGF)—induced signalling pathways. This work finds that AA is a new promising potential candidate drug for echinococcosis treatment. |
| first_indexed | 2024-04-13T12:42:54Z |
| format | Article |
| id | doaj.art-a210f9a97daf4ad18529b361f10e0469 |
| institution | Directory Open Access Journal |
| issn | 1297-9716 |
| language | English |
| last_indexed | 2024-04-13T12:42:54Z |
| publishDate | 2019-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Veterinary Research |
| spelling | doaj.art-a210f9a97daf4ad18529b361f10e04692022-12-22T02:46:28ZengBMCVeterinary Research1297-97162019-01-0150111110.1186/s13567-019-0621-7Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesisMiaomiao Yuan0Xiaoxia Song1Wei Lv2Qi Xin3Li Wang4Qi Gao5Guochao Zhang6Wenzhen Liao7Sen Lian8Tao Jing9School of Basic Medical Sciences, Lanzhou UniversitySchool of Basic Medical Sciences, Lanzhou UniversitySchool of Basic Medical Sciences, Lanzhou UniversitySchool of Basic Medical Sciences, Lanzhou UniversitySchool of Basic Medical Sciences, Lanzhou UniversitySchool of Basic Medical Sciences, Lanzhou UniversitySchool of Basic Medical Sciences, Lanzhou UniversityDepartment of Nutrition and Food Hygiene, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical UniversityDepartment of Biochemistry and Molecular Biology, Guangdong Provincial Key Laboratory of Biochip, School of Basic Medical Sciences, Southern Medical UniversitySchool of Basic Medical Sciences, Lanzhou UniversityAbstract Echinococcosis is a zoonotic infection caused by cestode species of the genus Echinococcus, with limited treatment options. It is urgent to develop new anti-hydatid agent. In this paper, we reported anacardic acid (AA), a natural product isolated from the Brazilian cashew-nut shell liquid, which presented a high activity against metacestodes of Echinococcus multilocularis (E. multilocularis) and Echinococcus granulosus sensu stricto (E. granulosus s.s.) in vitro and in vivo. AA exerted a better efficacy on E. granulosus s.s. protoscoleces and E. multilocularis metacestodes than that of albendazole (ABZ) and dihydroartemisinin (DHA) in vitro, and an inhibition on the growth of Echinococcus metacestode as effective as ABZ in vivo. Moreover, we also found that one of the mechanisms of AA against Echinococcus could be the suppression of angiogenesis on/in the metacestode mass through inhibiting vascular endothelial growth factor (VEGF)—induced signalling pathways. This work finds that AA is a new promising potential candidate drug for echinococcosis treatment.http://link.springer.com/article/10.1186/s13567-019-0621-7 |
| spellingShingle | Miaomiao Yuan Xiaoxia Song Wei Lv Qi Xin Li Wang Qi Gao Guochao Zhang Wenzhen Liao Sen Lian Tao Jing Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis Veterinary Research |
| title | Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis |
| title_full | Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis |
| title_fullStr | Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis |
| title_full_unstemmed | Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis |
| title_short | Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis |
| title_sort | effect of anacardic acid against echinococcosis through inhibition of vegf induced angiogenesis |
| url | http://link.springer.com/article/10.1186/s13567-019-0621-7 |
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