Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult Population.
Prehypertension is associated with cardiovascular disease (CVD). There is no study to examine the incidence and risk factors of prehypertension in a sex stratified setting. The aim of this study was to examine the effect modification of sex for different risk factors which predicts the progression f...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4595371?pdf=render |
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| author | Farzad Hadaegh Mitra Hasheminia Hengameh Abdi Davood Khalili Mohammadreza Bozorgmanesh Banafsheh Arshi Fereidoun Azizi |
| author_facet | Farzad Hadaegh Mitra Hasheminia Hengameh Abdi Davood Khalili Mohammadreza Bozorgmanesh Banafsheh Arshi Fereidoun Azizi |
| author_sort | Farzad Hadaegh |
| collection | DOAJ |
| description | Prehypertension is associated with cardiovascular disease (CVD). There is no study to examine the incidence and risk factors of prehypertension in a sex stratified setting. The aim of this study was to examine the effect modification of sex for different risk factors which predicts the progression from normotension to prehypertension in a Middle East population-based cohort, during a median follow-up of 9.2 years.A multivariate Cox analysis was performed among 1466 and 2131 Iranian men and women, respectively, who were free of prehypertension, hypertension, CVD and diabetes at baseline and free of incident hypertension without preceding prehypertension at follow-up. Incident prehypertension at follow-up was defined as systolic blood pressure (SBP) of 120-139 mmHg and/or diastolic blood pressure (DBP) of 80-89 mmHg.Overall, 1440 new cases of prehypertension were identified resulting in an incidence rate of 593/10000 person-years; the corresponding values for women and men were 489/10000 and 764/10000person-years, respectively. There were significant interactions between gender with age, DBP, waist-to-hip-ratio (WHpR) and estimated glomerular filtration rate (eGFR) (all P-values <0.05) in multivariate analysis. Strong associations were found between age, body mass index (BMI) and SBP with incident prehypertension in both genders. However, the effect of DBP and WHpR was significant among women and 2-hour post challenge plasma glucose (2h-PCPG)was an independent risk factor for men. In the sex-adjusted analysis, glomerular hyperfiltration [Hazard ratio (HR) and 95%CI: 1.01 (1.00-1.01), P-value = 0.02], age, BMI, WHpR, SBP and DBP had higher risks while being female [HR (95%CI): 0.81(0.69-0.94), P-value = 0.01] had a lower risk for incident prehypertension.According to this study results, among Iranian population with high incidence of prehypertension, general adiposity and glomerular hyperfiltration in total, 2h-PCPG in men and central adiposity in women should be emphasized as risk factors for prehypertension. |
| first_indexed | 2024-12-23T10:15:06Z |
| format | Article |
| id | doaj.art-a2117d81585c4a34ad94beac9ecafeb5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T10:15:06Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a2117d81585c4a34ad94beac9ecafeb52022-12-21T17:50:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e013941210.1371/journal.pone.0139412Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult Population.Farzad HadaeghMitra HasheminiaHengameh AbdiDavood KhaliliMohammadreza BozorgmaneshBanafsheh ArshiFereidoun AziziPrehypertension is associated with cardiovascular disease (CVD). There is no study to examine the incidence and risk factors of prehypertension in a sex stratified setting. The aim of this study was to examine the effect modification of sex for different risk factors which predicts the progression from normotension to prehypertension in a Middle East population-based cohort, during a median follow-up of 9.2 years.A multivariate Cox analysis was performed among 1466 and 2131 Iranian men and women, respectively, who were free of prehypertension, hypertension, CVD and diabetes at baseline and free of incident hypertension without preceding prehypertension at follow-up. Incident prehypertension at follow-up was defined as systolic blood pressure (SBP) of 120-139 mmHg and/or diastolic blood pressure (DBP) of 80-89 mmHg.Overall, 1440 new cases of prehypertension were identified resulting in an incidence rate of 593/10000 person-years; the corresponding values for women and men were 489/10000 and 764/10000person-years, respectively. There were significant interactions between gender with age, DBP, waist-to-hip-ratio (WHpR) and estimated glomerular filtration rate (eGFR) (all P-values <0.05) in multivariate analysis. Strong associations were found between age, body mass index (BMI) and SBP with incident prehypertension in both genders. However, the effect of DBP and WHpR was significant among women and 2-hour post challenge plasma glucose (2h-PCPG)was an independent risk factor for men. In the sex-adjusted analysis, glomerular hyperfiltration [Hazard ratio (HR) and 95%CI: 1.01 (1.00-1.01), P-value = 0.02], age, BMI, WHpR, SBP and DBP had higher risks while being female [HR (95%CI): 0.81(0.69-0.94), P-value = 0.01] had a lower risk for incident prehypertension.According to this study results, among Iranian population with high incidence of prehypertension, general adiposity and glomerular hyperfiltration in total, 2h-PCPG in men and central adiposity in women should be emphasized as risk factors for prehypertension.http://europepmc.org/articles/PMC4595371?pdf=render |
| spellingShingle | Farzad Hadaegh Mitra Hasheminia Hengameh Abdi Davood Khalili Mohammadreza Bozorgmanesh Banafsheh Arshi Fereidoun Azizi Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult Population. PLoS ONE |
| title | Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult Population. |
| title_full | Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult Population. |
| title_fullStr | Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult Population. |
| title_full_unstemmed | Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult Population. |
| title_short | Prehypertension Tsunami: A Decade Follow-Up of an Iranian Adult Population. |
| title_sort | prehypertension tsunami a decade follow up of an iranian adult population |
| url | http://europepmc.org/articles/PMC4595371?pdf=render |
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