Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase-activated B2 receptor agonists

Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase-activated B2 receptor agonists

While bradykinin (BK) is known to be degraded by angiotensin converting enzyme (ACE), we have recently discovered that Met-Lys-BK-Ser-Ser is paradoxically activated by ACE. We designed and evaluated additional prodrug peptides extended around the BK sequence as potential ligands that could be locall...

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Bibliographic Details
Main Authors: Xavier eCharest-Morin, Caroline eRoy, Émile-Jacques eFortin, Johanne eBouthillier, François eMarceau
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Pharmacology
Subjects:
Bradykinin
vascular smooth muscle
angiotensin converting enzyme
arginine carboxypeptidases
B2 receptors for bradykinin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00032/full

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