Differential Effects of <i>Furin</i> Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice

Differential Effects of <i>Furin</i> Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice

The insulin receptor (IR) is critically involved in maintaining glucose homeostasis. It undergoes proteolytic cleavage by proprotein convertases, which is an essential step for its activation. The importance of the insulin receptor in liver is well established, but its role in pancreatic β cells is...

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Bibliographic Details
Main Authors: Ilaria Coppola, Bas Brouwers, Sandra Meulemans, Bruno Ramos-Molina, John W. M. Creemers
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
insulin receptor
proprotein convertase
FURIN
liver
pancreatic β cells
insulin signaling
Online Access:https://www.mdpi.com/1422-0067/22/12/6344

Internet

https://www.mdpi.com/1422-0067/22/12/6344

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