Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial)
To assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes. A two-phase, parallel, randomised, controlled clinical trial will be carried out, in 210 participants. In phase 1, 120 participants will be randomized into four arms:...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/12/1286 |
| _version_ | 1797456341430697984 |
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| author | Aina M Galmes-Panades Miquel Bennasar-Veny Paula Oliver Natalia Garcia-Coll Alice Chaplin Sergio Fresneda Laura Gallardo-Alfaro Carmen García-Ruano Jadwiga Konieczna Alfonso Leiva Lluis Masmiquel Catalina Pico Ignacio Ricci-Cabello Dora Romaguera Rosmeri Rivera Pilar Sanchis Josep Vidal-Conti Aina M Yañez |
| author_facet | Aina M Galmes-Panades Miquel Bennasar-Veny Paula Oliver Natalia Garcia-Coll Alice Chaplin Sergio Fresneda Laura Gallardo-Alfaro Carmen García-Ruano Jadwiga Konieczna Alfonso Leiva Lluis Masmiquel Catalina Pico Ignacio Ricci-Cabello Dora Romaguera Rosmeri Rivera Pilar Sanchis Josep Vidal-Conti Aina M Yañez |
| author_sort | Aina M Galmes-Panades |
| collection | DOAJ |
| description | To assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes. A two-phase, parallel, randomised, controlled clinical trial will be carried out, in 210 participants. In phase 1, 120 participants will be randomized into four arms: (1) aerobic exercise, (2) aerobic exercise combined with resistance, (3) high-intensity intervallic exercise and (4) control group. In phase 2, 90 new participants will be randomized into three arms, using the exercise modality that showed the best glycaemic control in phase 1 in the following manner: (1) frequency of 5 days/week, (2) frequency of 3 days/week and (3) frequency of 2 days/week. The control group (n = 30) will be included in phase 1 to evaluate the effect of any type of intervention versus no intervention. Data collection will be performed at baseline and after 15 weeks of follow up. Sociodemographic data, medication, comorbidity, blood biochemical parameters, blood pressure, anthropometric measurements, body composition, physical activity, sedentary lifestyle, diet, smoking, alcohol consumption, quality of life and sleep questionnaires will be collected. Physical activity, sedentary behaviour and sleep will be further determined with an accelerometer, and continuous glycaemia will be determined with a glycaemic monitor, both during seven days, at two time points. The main dependent variable will be the reduction in the mean amplitude of glycaemic excursions. The impact of these interventions on health will also be evaluated through gene expression analysis in peripheral blood cells. The results of this study will contribute to a better understanding of the mechanisms behind the glucose response to physical exercise in a population with prediabetes as well as improve physical exercise prescriptions for diabetes prevention. Increasing glycaemic control in people with prediabetes through physical exercise offers an opportunity to prevent diabetes and reduce associated comorbidities and health costs. |
| first_indexed | 2024-03-09T16:06:25Z |
| format | Article |
| id | doaj.art-a2135a3b5b5142ba98d56c4a2b6821a3 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T16:06:25Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-a2135a3b5b5142ba98d56c4a2b6821a32023-11-24T16:38:54ZengMDPI AGMetabolites2218-19892022-12-011212128610.3390/metabo12121286Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial)Aina M Galmes-Panades0Miquel Bennasar-Veny1Paula Oliver2Natalia Garcia-Coll3Alice Chaplin4Sergio Fresneda5Laura Gallardo-Alfaro6Carmen García-Ruano7Jadwiga Konieczna8Alfonso Leiva9Lluis Masmiquel10Catalina Pico11Ignacio Ricci-Cabello12Dora Romaguera13Rosmeri Rivera14Pilar Sanchis15Josep Vidal-Conti16Aina M Yañez17Global Health and Lifestyle (EVES Group), Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, SpainGlobal Health and Lifestyle (EVES Group), Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, SpainCIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainResearch group on Global Health and Human Development, University of the Balearic Islands (UIB), 07120 Palma, SpainCIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainGlobal Health and Lifestyle (EVES Group), Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, SpainHealth Research Institute of the Balearic Islands (IdISBa), 07120 Palma, SpainCIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainCIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainHealth Research Institute of the Balearic Islands (IdISBa), 07120 Palma, SpainVascular and Metabolic Diseases Research Group, Health Research Institute of the Balearic Islands [IdISBa], 07120 Palma, SpainCIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainCIBER de Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, 28029 Madrid, SpainCIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainVascular and Metabolic Diseases Research Group, Health Research Institute of the Balearic Islands [IdISBa], 07120 Palma, SpainCIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, SpainPhysical Activity and Sport Sciences Research Group (GICAFE), Institute for Educational Research and Innovation (IRIE), University of the Balearic Islands, 07120 Palma, SpainGlobal Health and Lifestyle (EVES Group), Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, SpainTo assess the efficacy of different modalities and frequencies of physical exercise on glycaemic control in adults with prediabetes. A two-phase, parallel, randomised, controlled clinical trial will be carried out, in 210 participants. In phase 1, 120 participants will be randomized into four arms: (1) aerobic exercise, (2) aerobic exercise combined with resistance, (3) high-intensity intervallic exercise and (4) control group. In phase 2, 90 new participants will be randomized into three arms, using the exercise modality that showed the best glycaemic control in phase 1 in the following manner: (1) frequency of 5 days/week, (2) frequency of 3 days/week and (3) frequency of 2 days/week. The control group (n = 30) will be included in phase 1 to evaluate the effect of any type of intervention versus no intervention. Data collection will be performed at baseline and after 15 weeks of follow up. Sociodemographic data, medication, comorbidity, blood biochemical parameters, blood pressure, anthropometric measurements, body composition, physical activity, sedentary lifestyle, diet, smoking, alcohol consumption, quality of life and sleep questionnaires will be collected. Physical activity, sedentary behaviour and sleep will be further determined with an accelerometer, and continuous glycaemia will be determined with a glycaemic monitor, both during seven days, at two time points. The main dependent variable will be the reduction in the mean amplitude of glycaemic excursions. The impact of these interventions on health will also be evaluated through gene expression analysis in peripheral blood cells. The results of this study will contribute to a better understanding of the mechanisms behind the glucose response to physical exercise in a population with prediabetes as well as improve physical exercise prescriptions for diabetes prevention. Increasing glycaemic control in people with prediabetes through physical exercise offers an opportunity to prevent diabetes and reduce associated comorbidities and health costs.https://www.mdpi.com/2218-1989/12/12/1286exerciseprediabetesaerobic exerciseresistance trainingtype 2 diabetes |
| spellingShingle | Aina M Galmes-Panades Miquel Bennasar-Veny Paula Oliver Natalia Garcia-Coll Alice Chaplin Sergio Fresneda Laura Gallardo-Alfaro Carmen García-Ruano Jadwiga Konieczna Alfonso Leiva Lluis Masmiquel Catalina Pico Ignacio Ricci-Cabello Dora Romaguera Rosmeri Rivera Pilar Sanchis Josep Vidal-Conti Aina M Yañez Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial) Metabolites exercise prediabetes aerobic exercise resistance training type 2 diabetes |
| title | Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial) |
| title_full | Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial) |
| title_fullStr | Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial) |
| title_full_unstemmed | Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial) |
| title_short | Efficacy of Different Modalities and Frequencies of Physical Exercise on Glucose Control in People with Prediabetes (GLYCEX Randomised Trial) |
| title_sort | efficacy of different modalities and frequencies of physical exercise on glucose control in people with prediabetes glycex randomised trial |
| topic | exercise prediabetes aerobic exercise resistance training type 2 diabetes |
| url | https://www.mdpi.com/2218-1989/12/12/1286 |
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