Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity?
Abstract Background The association between oral dysbiosis and chronic kidney disease (CKD) has gained increasing attention in recent years. Diabetes and hypertension are the most common conditions in CKD. However, a case–control study with matched confounding variables on the salivary microbiome in...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-022-03602-5 |
| _version_ | 1798004449187201024 |
|---|---|
| author | Fengping Liu Jiayi Sheng Lei Hu Bin Zhang Wei Guo Yang Wang Yifeng Gu Peng Jiang Hao Lin Brako Lydia Yifan Sun Yifan Tang Chaoqun Gu Shichao Wei Qixiao Zhai Weiguo Chen Ninghan Feng |
| author_facet | Fengping Liu Jiayi Sheng Lei Hu Bin Zhang Wei Guo Yang Wang Yifeng Gu Peng Jiang Hao Lin Brako Lydia Yifan Sun Yifan Tang Chaoqun Gu Shichao Wei Qixiao Zhai Weiguo Chen Ninghan Feng |
| author_sort | Fengping Liu |
| collection | DOAJ |
| description | Abstract Background The association between oral dysbiosis and chronic kidney disease (CKD) has gained increasing attention in recent years. Diabetes and hypertension are the most common conditions in CKD. However, a case–control study with matched confounding variables on the salivary microbiome in CKD and the influence of diabetes and hypertension on the microbiome has never been reported. Methods In our study, we compared the salivary microbiome profile between patients with CKD and healthy controls (HC) using 16S ribosomal DNA sequencing and examine its association with diabetes, hypertension, and immunity. Results We observed that the bacterial community was skewed in the saliva of CKD, with increased Lautropia and Pseudomonas, and decreased Actinomyces, Prevotella, Prevotella 7, and Trichococcus. No difference in the bacterial community between the CKD patients complicated with and without diabetes, and between those with and without hypertension. Prevotella 7 declined in CKD patients with/without hypertension with respect to HC, while Pseudomonas increased in CKD patients with/without hypertension. Pseudomonas was negatively associated with immunoglobin G in CKD patients. Both CKD patients with positive and negative antistreptolysin O had declined Prevotella 7 and Trichococcus compared to HC, whereas increased Pseudomonas. Conclusions Our study identifies a distinct bacterial saliva microbiome in CKD patients characterized by alteration in composition. We unravel here that the co-occurrence diseases of diabetes and hypertension are not associated with specific bacterial alterations, suggesting that bacterial dysbiosis in saliva plays a role in renal damage regardless of the occurrence of diabetes and hypertension. |
| first_indexed | 2024-04-11T12:23:55Z |
| format | Article |
| id | doaj.art-a213fd8910fc4c32ac54b752971b55a9 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-11T12:23:55Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-a213fd8910fc4c32ac54b752971b55a92022-12-22T04:24:00ZengBMCJournal of Translational Medicine1479-58762022-09-0120111410.1186/s12967-022-03602-5Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity?Fengping Liu0Jiayi Sheng1Lei Hu2Bin Zhang3Wei Guo4Yang Wang5Yifeng Gu6Peng Jiang7Hao Lin8Brako Lydia9Yifan Sun10Yifan Tang11Chaoqun Gu12Shichao Wei13Qixiao Zhai14Weiguo Chen15Ninghan Feng16Wuxi School of Medicine, Jiangnan UniversityDepartment of Urology, Wuxi No.2 People’s Hospital, Affiliated Wuxi Second Hospital of Nanjing Medical UniversityDepartment of Urology, Wuxi No.2 People’s Hospital, Affiliated Wuxi Second Hospital of Nanjing Medical UniversityDepartment of Urology, the First Affiliated Hospital of Soochow UniversityDepartment of Urology, Wuxi No.2 People’s Hospital, Affiliated Wuxi Second Hospital of Nanjing Medical UniversityDepartment of Urology, Wuxi No.2 People’s Hospital, Affiliated Wuxi Second Hospital of Nanjing Medical UniversityCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, The First Affiliated Hospital, Zhejiang UniversityDepartment of Urology, Wuxi No.2 People’s Hospital, Affiliated Wuxi Second Hospital of Nanjing Medical UniversityDepartment of Urology, Wuxi No.2 People’s Hospital, Affiliated Wuxi Second Hospital of Nanjing Medical UniversityWuxi School of Medicine, Jiangnan UniversityDepartment of Urology, Wuxi No.2 People’s Hospital, Affiliated Wuxi Second Hospital of Nanjing Medical UniversityDepartment of Urology, Wuxi No.2 People’s Hospital, Affiliated Wuxi Second Hospital of Nanjing Medical UniversitySchool of Medicine, Nantong UniversitySchool of Medicine, Nantong UniversityState Key Laboratory of Food Science and Technology and School of Food Science and Technology, Jiangnan UniversityDepartment of Urology, the First Affiliated Hospital of Soochow UniversityDepartment of Urology, Wuxi No.2 People’s Hospital, Affiliated Wuxi Second Hospital of Nanjing Medical UniversityAbstract Background The association between oral dysbiosis and chronic kidney disease (CKD) has gained increasing attention in recent years. Diabetes and hypertension are the most common conditions in CKD. However, a case–control study with matched confounding variables on the salivary microbiome in CKD and the influence of diabetes and hypertension on the microbiome has never been reported. Methods In our study, we compared the salivary microbiome profile between patients with CKD and healthy controls (HC) using 16S ribosomal DNA sequencing and examine its association with diabetes, hypertension, and immunity. Results We observed that the bacterial community was skewed in the saliva of CKD, with increased Lautropia and Pseudomonas, and decreased Actinomyces, Prevotella, Prevotella 7, and Trichococcus. No difference in the bacterial community between the CKD patients complicated with and without diabetes, and between those with and without hypertension. Prevotella 7 declined in CKD patients with/without hypertension with respect to HC, while Pseudomonas increased in CKD patients with/without hypertension. Pseudomonas was negatively associated with immunoglobin G in CKD patients. Both CKD patients with positive and negative antistreptolysin O had declined Prevotella 7 and Trichococcus compared to HC, whereas increased Pseudomonas. Conclusions Our study identifies a distinct bacterial saliva microbiome in CKD patients characterized by alteration in composition. We unravel here that the co-occurrence diseases of diabetes and hypertension are not associated with specific bacterial alterations, suggesting that bacterial dysbiosis in saliva plays a role in renal damage regardless of the occurrence of diabetes and hypertension.https://doi.org/10.1186/s12967-022-03602-5Chronic kidney diseaseDiabetesHypertensionImmunologySalivary microbiome |
| spellingShingle | Fengping Liu Jiayi Sheng Lei Hu Bin Zhang Wei Guo Yang Wang Yifeng Gu Peng Jiang Hao Lin Brako Lydia Yifan Sun Yifan Tang Chaoqun Gu Shichao Wei Qixiao Zhai Weiguo Chen Ninghan Feng Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity? Journal of Translational Medicine Chronic kidney disease Diabetes Hypertension Immunology Salivary microbiome |
| title | Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity? |
| title_full | Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity? |
| title_fullStr | Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity? |
| title_full_unstemmed | Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity? |
| title_short | Salivary microbiome in chronic kidney disease: what is its connection to diabetes, hypertension, and immunity? |
| title_sort | salivary microbiome in chronic kidney disease what is its connection to diabetes hypertension and immunity |
| topic | Chronic kidney disease Diabetes Hypertension Immunology Salivary microbiome |
| url | https://doi.org/10.1186/s12967-022-03602-5 |
| work_keys_str_mv | AT fengpingliu salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT jiayisheng salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT leihu salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT binzhang salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT weiguo salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT yangwang salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT yifenggu salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT pengjiang salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT haolin salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT brakolydia salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT yifansun salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT yifantang salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT chaoqungu salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT shichaowei salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT qixiaozhai salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT weiguochen salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity AT ninghanfeng salivarymicrobiomeinchronickidneydiseasewhatisitsconnectiontodiabeteshypertensionandimmunity |