Prevalence of Thyroid Dysfunctions in Patients with Rheumatoid Arthritis at Tertiary Care Hospital
BACKGROUND: Thyroid dysfunctions frequently co-exist in patients with Autoimmune disorders like rheumatoid arthritis, systemic lupus erythematosus (SLE), and Vasculitis. Presence of thyroid dysfunctions in patients with rheumatoid arthritis increase the co-morbidities and mortality some time becaus...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dow University of Health Sciences
2021-08-01
|
| Series: | Journal of the Dow University of Health Sciences |
| Subjects: | |
| Online Access: | https://jduhs.com/index.php/jduhs/article/view/1191 |
| _version_ | 1797810656723861504 |
|---|---|
| author | Nand Lal Seeran Nasrullah Aamer Muhammad Tariq Karim Shafique Rehman Arain Furqan Khan Assadullah Dahani |
| author_facet | Nand Lal Seeran Nasrullah Aamer Muhammad Tariq Karim Shafique Rehman Arain Furqan Khan Assadullah Dahani |
| author_sort | Nand Lal Seeran |
| collection | DOAJ |
| description |
BACKGROUND: Thyroid dysfunctions frequently co-exist in patients with Autoimmune disorders like rheumatoid arthritis, systemic lupus erythematosus (SLE), and Vasculitis. Presence of thyroid dysfunctions in patients with rheumatoid arthritis increase the co-morbidities and mortality some time because of cardiovascular complications.
Objective
This study was conducted to determine the burden of thyroid dysfunctions in rheumatoid arthritis patients attending tertiary care hospital of Karachi, Pakistan.
METHODS: A cross-sectional study was conducted at rheumatology clinic of a Jinnah Post Graduate Medical Centre in Karachi, Pakistan from April 2019 to January 2021. All diagnosed cases of rheumatoid arthritis having seronegative or seropositive rheumatoid arthritis were consecutively enrolled. Clinical records and laboratory data of these patients were collected along with outcome variables.
RESULTS: Of 136 patients, thyroid abnormality was observed in 56 (41.2%) patients. In particular, 80 (58.8%) had normal, 8 (5.9%) had hypothyroidism, 14 (10.3%) had hyperthyroidism, 32 (10.5%) had subclinical hypothyroidism, and 2 (1.5%) had subclinical hyperthyroidism. A significantly lower hemoglobin levels (p-value <0.001), mean corpuscular volume (p-value 0.011), total leucocyte count (p-value 0.004), and platelet counts (p-value 0.040) were observed in patients with thyroid abnormality than those without thyroid abnormality. Furthermore, a significantly lower urea (p-value <0.001) and creatinine levels (p-value <0.001) were also observed among patients with thyroid abnormality than those without thyroid abnormality.
CONCLUSION: In patients with rheumatoid arthritis, thyroid dysfunction has been shown to be highly prevalent. Subclinical hypothyroidism, the most common thyroid disorder and obvious hyperthyroidism were observed.
|
| first_indexed | 2024-03-13T07:11:04Z |
| format | Article |
| id | doaj.art-a2157645ba744e5aab2ab371776992a7 |
| institution | Directory Open Access Journal |
| issn | 1995-2198 2410-2180 |
| language | English |
| last_indexed | 2024-03-13T07:11:04Z |
| publishDate | 2021-08-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj.art-a2157645ba744e5aab2ab371776992a72023-06-06T03:12:08ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802021-08-0115210.36570/jduhs.2021.2.1191Prevalence of Thyroid Dysfunctions in Patients with Rheumatoid Arthritis at Tertiary Care HospitalNand Lal Seeran0Nasrullah Aamer1Muhammad Tariq Karim2Shafique Rehman Arain3Furqan Khan4Assadullah Dahani5Department of Gastroenterology. Liaquat University of Medical and Health Sciences, Hyderabad.Department of Medicine. Peoples University of Medical and Health Sciences, Shaheed Benazirabad, Nawabshah.Head of Research Evaluation Unit. College of Physicians and Surgeons, Karachi.Jinnah Postgraduate Medical Center. KarachiDepartment of Rheumatology. Medical Ward-6. Jinnah Postgraduate Medical Center, KarachiDepartment of Rheumatology. Medical Ward-6. Jinnah Postgraduate Medical Center, Karachi BACKGROUND: Thyroid dysfunctions frequently co-exist in patients with Autoimmune disorders like rheumatoid arthritis, systemic lupus erythematosus (SLE), and Vasculitis. Presence of thyroid dysfunctions in patients with rheumatoid arthritis increase the co-morbidities and mortality some time because of cardiovascular complications. Objective This study was conducted to determine the burden of thyroid dysfunctions in rheumatoid arthritis patients attending tertiary care hospital of Karachi, Pakistan. METHODS: A cross-sectional study was conducted at rheumatology clinic of a Jinnah Post Graduate Medical Centre in Karachi, Pakistan from April 2019 to January 2021. All diagnosed cases of rheumatoid arthritis having seronegative or seropositive rheumatoid arthritis were consecutively enrolled. Clinical records and laboratory data of these patients were collected along with outcome variables. RESULTS: Of 136 patients, thyroid abnormality was observed in 56 (41.2%) patients. In particular, 80 (58.8%) had normal, 8 (5.9%) had hypothyroidism, 14 (10.3%) had hyperthyroidism, 32 (10.5%) had subclinical hypothyroidism, and 2 (1.5%) had subclinical hyperthyroidism. A significantly lower hemoglobin levels (p-value <0.001), mean corpuscular volume (p-value 0.011), total leucocyte count (p-value 0.004), and platelet counts (p-value 0.040) were observed in patients with thyroid abnormality than those without thyroid abnormality. Furthermore, a significantly lower urea (p-value <0.001) and creatinine levels (p-value <0.001) were also observed among patients with thyroid abnormality than those without thyroid abnormality. CONCLUSION: In patients with rheumatoid arthritis, thyroid dysfunction has been shown to be highly prevalent. Subclinical hypothyroidism, the most common thyroid disorder and obvious hyperthyroidism were observed. https://jduhs.com/index.php/jduhs/article/view/1191Rheumatoid arthritis, thyroid dysfunction, Hypothyroidism, Hyperthyroidism. |
| spellingShingle | Nand Lal Seeran Nasrullah Aamer Muhammad Tariq Karim Shafique Rehman Arain Furqan Khan Assadullah Dahani Prevalence of Thyroid Dysfunctions in Patients with Rheumatoid Arthritis at Tertiary Care Hospital Journal of the Dow University of Health Sciences Rheumatoid arthritis, thyroid dysfunction, Hypothyroidism, Hyperthyroidism. |
| title | Prevalence of Thyroid Dysfunctions in Patients with Rheumatoid Arthritis at Tertiary Care Hospital |
| title_full | Prevalence of Thyroid Dysfunctions in Patients with Rheumatoid Arthritis at Tertiary Care Hospital |
| title_fullStr | Prevalence of Thyroid Dysfunctions in Patients with Rheumatoid Arthritis at Tertiary Care Hospital |
| title_full_unstemmed | Prevalence of Thyroid Dysfunctions in Patients with Rheumatoid Arthritis at Tertiary Care Hospital |
| title_short | Prevalence of Thyroid Dysfunctions in Patients with Rheumatoid Arthritis at Tertiary Care Hospital |
| title_sort | prevalence of thyroid dysfunctions in patients with rheumatoid arthritis at tertiary care hospital |
| topic | Rheumatoid arthritis, thyroid dysfunction, Hypothyroidism, Hyperthyroidism. |
| url | https://jduhs.com/index.php/jduhs/article/view/1191 |
| work_keys_str_mv | AT nandlalseeran prevalenceofthyroiddysfunctionsinpatientswithrheumatoidarthritisattertiarycarehospital AT nasrullahaamer prevalenceofthyroiddysfunctionsinpatientswithrheumatoidarthritisattertiarycarehospital AT muhammadtariqkarim prevalenceofthyroiddysfunctionsinpatientswithrheumatoidarthritisattertiarycarehospital AT shafiquerehmanarain prevalenceofthyroiddysfunctionsinpatientswithrheumatoidarthritisattertiarycarehospital AT furqankhan prevalenceofthyroiddysfunctionsinpatientswithrheumatoidarthritisattertiarycarehospital AT assadullahdahani prevalenceofthyroiddysfunctionsinpatientswithrheumatoidarthritisattertiarycarehospital |