Impact of Co-morbidities on Outcome of COVID-19 Patients: An Observational Study among Patients Admitted to Intensive Care Unit
Introduction: Coronavirus Disease-2019 (COVID-19) has been a major cause of apprehension, morbidity, and mortality in 2020. It had been postulated that associated co-morbid conditions in COVID-19 patients increase the severity of COVID-19 which leads to six times more chances of hospitalisation...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/15163/48792_CE[Ra1]_F[IK]_PF1(AkA_OM)_PN(KM).pdf |
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| author | Hemant Kumar Sumeet Dixit Nikhil Gupta preeti gupta Manoj Kumar Pandey Shobhit Shakya Amiya Kumar Pandey |
| author_facet | Hemant Kumar Sumeet Dixit Nikhil Gupta preeti gupta Manoj Kumar Pandey Shobhit Shakya Amiya Kumar Pandey |
| author_sort | Hemant Kumar |
| collection | DOAJ |
| description | Introduction: Coronavirus Disease-2019 (COVID-19) has been
a major cause of apprehension, morbidity, and mortality in 2020.
It had been postulated that associated co-morbid conditions
in COVID-19 patients increase the severity of COVID-19 which
leads to six times more chances of hospitalisation than patients
without co-morbid condition. Mortality is also 12 times higher
in such patients.
Aim: To find out the association between co-morbidities and
mortalities due to COVID-19 pneumonia.
Materials and Methods: A prospective, observational study
was conducted in a tertiary teaching institute of North India
which was designated Level 3 (L-3) facility for treatment of
COVID-19 patients. All 109 COVID-19 patients confirmed by
Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR),
admitted in Intensive Care Unit (ICU) from 1st July 2020 to 30th
November 2020 formed the sample of the study. Data was taken
regarding past history, clinical histories and examinations and
ICU care and treatments. Based on their final outcome at the
end of ICU care, patients were divided into two groups-group 1
(Non-survivor or Expired) and group 2 (Survived) and intergroup
differences were studied.
Results: COVID-19 infection was about three times more
common in males. Severe category of COVID-19 patients had
higher mortality (59.2 % of severe category expired during
hospital course, 1.7% patients expired in moderate category
group). Most common co-morbidities were hypertension
(n=51, 46.8%) and diabetes (n=48, 44%). Multivariate
analysis showed that co-morbidities in the form of chronic
liver disease (OR -0.127(0.024-0.681, p-value 0.016)) and
post tubercular sequel (OR 0.036(0.003-0.442, p-value 0.009))
were less likely to occur in COVID-19 patients who survived,
thus making these co-morbidities significant contributor to
the adverse outcomes in COVID-19 patients. More number
of co-morbidities in a patient were associated with higher
chance of mortality and this trend was significant statistically
(p-value<0.001).
Conclusion: Patients with multiple co-morbidities, chronic liver
disease and post tubercular sequel were associated with higher
mortality in COVID-19 patients. |
| first_indexed | 2024-12-20T04:02:40Z |
| format | Article |
| id | doaj.art-a2162014be944caea8d02e591100883a |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-20T04:02:40Z |
| publishDate | 2021-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-a2162014be944caea8d02e591100883a2022-12-21T19:54:08ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-07-011507485110.7860/JCDR/2021/48792.15163Impact of Co-morbidities on Outcome of COVID-19 Patients: An Observational Study among Patients Admitted to Intensive Care UnitHemant KumarSumeet Dixit Nikhil Guptapreeti guptaManoj Kumar PandeyShobhit ShakyaAmiya Kumar PandeyIntroduction: Coronavirus Disease-2019 (COVID-19) has been a major cause of apprehension, morbidity, and mortality in 2020. It had been postulated that associated co-morbid conditions in COVID-19 patients increase the severity of COVID-19 which leads to six times more chances of hospitalisation than patients without co-morbid condition. Mortality is also 12 times higher in such patients. Aim: To find out the association between co-morbidities and mortalities due to COVID-19 pneumonia. Materials and Methods: A prospective, observational study was conducted in a tertiary teaching institute of North India which was designated Level 3 (L-3) facility for treatment of COVID-19 patients. All 109 COVID-19 patients confirmed by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR), admitted in Intensive Care Unit (ICU) from 1st July 2020 to 30th November 2020 formed the sample of the study. Data was taken regarding past history, clinical histories and examinations and ICU care and treatments. Based on their final outcome at the end of ICU care, patients were divided into two groups-group 1 (Non-survivor or Expired) and group 2 (Survived) and intergroup differences were studied. Results: COVID-19 infection was about three times more common in males. Severe category of COVID-19 patients had higher mortality (59.2 % of severe category expired during hospital course, 1.7% patients expired in moderate category group). Most common co-morbidities were hypertension (n=51, 46.8%) and diabetes (n=48, 44%). Multivariate analysis showed that co-morbidities in the form of chronic liver disease (OR -0.127(0.024-0.681, p-value 0.016)) and post tubercular sequel (OR 0.036(0.003-0.442, p-value 0.009)) were less likely to occur in COVID-19 patients who survived, thus making these co-morbidities significant contributor to the adverse outcomes in COVID-19 patients. More number of co-morbidities in a patient were associated with higher chance of mortality and this trend was significant statistically (p-value<0.001). Conclusion: Patients with multiple co-morbidities, chronic liver disease and post tubercular sequel were associated with higher mortality in COVID-19 patients.https://jcdr.net/articles/PDF/15163/48792_CE[Ra1]_F[IK]_PF1(AkA_OM)_PN(KM).pdfchronic liver diseasemortalitypneumoniasevere acute respiratory syndrome coronavirus-2coronavirus disease-2019 |
| spellingShingle | Hemant Kumar Sumeet Dixit Nikhil Gupta preeti gupta Manoj Kumar Pandey Shobhit Shakya Amiya Kumar Pandey Impact of Co-morbidities on Outcome of COVID-19 Patients: An Observational Study among Patients Admitted to Intensive Care Unit Journal of Clinical and Diagnostic Research chronic liver disease mortality pneumonia severe acute respiratory syndrome coronavirus-2 coronavirus disease-2019 |
| title | Impact of Co-morbidities on Outcome of COVID-19 Patients: An Observational Study among Patients Admitted to Intensive Care Unit |
| title_full | Impact of Co-morbidities on Outcome of COVID-19 Patients: An Observational Study among Patients Admitted to Intensive Care Unit |
| title_fullStr | Impact of Co-morbidities on Outcome of COVID-19 Patients: An Observational Study among Patients Admitted to Intensive Care Unit |
| title_full_unstemmed | Impact of Co-morbidities on Outcome of COVID-19 Patients: An Observational Study among Patients Admitted to Intensive Care Unit |
| title_short | Impact of Co-morbidities on Outcome of COVID-19 Patients: An Observational Study among Patients Admitted to Intensive Care Unit |
| title_sort | impact of co morbidities on outcome of covid 19 patients an observational study among patients admitted to intensive care unit |
| topic | chronic liver disease mortality pneumonia severe acute respiratory syndrome coronavirus-2 coronavirus disease-2019 |
| url | https://jcdr.net/articles/PDF/15163/48792_CE[Ra1]_F[IK]_PF1(AkA_OM)_PN(KM).pdf |
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