Surgical techniques and function outcome for cingulate gyrus glioma, how we do it
ObjectiveCingulate cortex and cingulum both play crucial roles in limbic system. The aim of study is to observe and analyze surgical outcomes of cingulate gyrus glioma through extents of resection (EORs), overall survival (OS), and postsurgical neurological outcome.MethodThe authors retrospectively...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.986387/full |
| _version_ | 1811204325194596352 |
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| author | Fangyuan Gong Lei Jin Qiuwei Song Zhong Yang Hong Chen Jinsong Wu |
| author_facet | Fangyuan Gong Lei Jin Qiuwei Song Zhong Yang Hong Chen Jinsong Wu |
| author_sort | Fangyuan Gong |
| collection | DOAJ |
| description | ObjectiveCingulate cortex and cingulum both play crucial roles in limbic system. The aim of study is to observe and analyze surgical outcomes of cingulate gyrus glioma through extents of resection (EORs), overall survival (OS), and postsurgical neurological outcome.MethodThe authors retrospectively studied 95 consecutive adult cases of primary cingulate gliomas that all underwent craniotomies and tumor resection. The patients were classified into unitary sub-region based on the four-division model. The information of clinical symptoms, pathology, EOR, postoperative neurological outcome and survival were analyzed through group comparison.ResultLow-grade gliomas (LGGs) were more prevalent (69.47%) for cingulate gyrus. Diffuse astrocytoma (40.00%) was most common histopathological diagnosis in total. Regarding sub-regions tumor involved in, midcingulate cortex (MCC) glioma was most prevalent (54.74%) followed by anterior cingulate cortex (ACC) glioma. Among all patients, 83 patients (87.37%) received EOR ≥ 90%. In LGG group, 58 patients (87.88%) received EOR ≥ 90%. The achievement of EOR significantly correlated with survival (P = 0.006). MCC cases were significantly associated with short-term morbidity in either language or motor function (P = 0.02). Majority of ACC cases (80.65%) escaped from any short-term deficits and nearly 90% free for permanent morbidity. Tumors in the dominant hemisphere were significantly associated with language dysfunction or cognition dysfunction, either short-term (P=0.0006) or long-term morbidity (P=0.0111). Age was the only postoperative susceptible predictor for all types of transient (P=0.021) and permanent (P=0.02) neurological deficit.ConclusionRegarding cingulate gyrus glioma, the management of surgical plans could be carried out into four sub-region level. In spite of short-term neurological dysfunction caused by surgical procedure, majority of transient dysfunction could be relieved or recovered in long-term. The necessary effort to prolong overall survival is still to achieve advisable EOR. |
| first_indexed | 2024-04-12T03:11:10Z |
| format | Article |
| id | doaj.art-a2163a2344124ff088914ba3b22171e6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T03:11:10Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a2163a2344124ff088914ba3b22171e62022-12-22T03:50:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.986387986387Surgical techniques and function outcome for cingulate gyrus glioma, how we do itFangyuan Gong0Lei Jin1Qiuwei Song2Zhong Yang3Hong Chen4Jinsong Wu5Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Nursing, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Pathology, Huashan Hospital, Fudan University, Shanghai, ChinaDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, ChinaObjectiveCingulate cortex and cingulum both play crucial roles in limbic system. The aim of study is to observe and analyze surgical outcomes of cingulate gyrus glioma through extents of resection (EORs), overall survival (OS), and postsurgical neurological outcome.MethodThe authors retrospectively studied 95 consecutive adult cases of primary cingulate gliomas that all underwent craniotomies and tumor resection. The patients were classified into unitary sub-region based on the four-division model. The information of clinical symptoms, pathology, EOR, postoperative neurological outcome and survival were analyzed through group comparison.ResultLow-grade gliomas (LGGs) were more prevalent (69.47%) for cingulate gyrus. Diffuse astrocytoma (40.00%) was most common histopathological diagnosis in total. Regarding sub-regions tumor involved in, midcingulate cortex (MCC) glioma was most prevalent (54.74%) followed by anterior cingulate cortex (ACC) glioma. Among all patients, 83 patients (87.37%) received EOR ≥ 90%. In LGG group, 58 patients (87.88%) received EOR ≥ 90%. The achievement of EOR significantly correlated with survival (P = 0.006). MCC cases were significantly associated with short-term morbidity in either language or motor function (P = 0.02). Majority of ACC cases (80.65%) escaped from any short-term deficits and nearly 90% free for permanent morbidity. Tumors in the dominant hemisphere were significantly associated with language dysfunction or cognition dysfunction, either short-term (P=0.0006) or long-term morbidity (P=0.0111). Age was the only postoperative susceptible predictor for all types of transient (P=0.021) and permanent (P=0.02) neurological deficit.ConclusionRegarding cingulate gyrus glioma, the management of surgical plans could be carried out into four sub-region level. In spite of short-term neurological dysfunction caused by surgical procedure, majority of transient dysfunction could be relieved or recovered in long-term. The necessary effort to prolong overall survival is still to achieve advisable EOR.https://www.frontiersin.org/articles/10.3389/fonc.2022.986387/fullcingulategliomasubregionsurgeryprognosisoncology |
| spellingShingle | Fangyuan Gong Lei Jin Qiuwei Song Zhong Yang Hong Chen Jinsong Wu Surgical techniques and function outcome for cingulate gyrus glioma, how we do it Frontiers in Oncology cingulate glioma subregion surgery prognosis oncology |
| title | Surgical techniques and function outcome for cingulate gyrus glioma, how we do it |
| title_full | Surgical techniques and function outcome for cingulate gyrus glioma, how we do it |
| title_fullStr | Surgical techniques and function outcome for cingulate gyrus glioma, how we do it |
| title_full_unstemmed | Surgical techniques and function outcome for cingulate gyrus glioma, how we do it |
| title_short | Surgical techniques and function outcome for cingulate gyrus glioma, how we do it |
| title_sort | surgical techniques and function outcome for cingulate gyrus glioma how we do it |
| topic | cingulate glioma subregion surgery prognosis oncology |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.986387/full |
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