Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT study
Abstract Background The terms affective dysregulation (AD) and irritability describe transdiagnostic dimensions and are characterized by an excessive reactivity to negative emotional stimuli with an affective (anger) and a behavioral component (aggression). Due to early onset, high prevalence and pe...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12888-019-2239-8 |
| _version_ | 1818138668912607232 |
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| author | Manfred Döpfner Josepha Katzmann Charlotte Hanisch Jörg M. Fegert Michael Kölch Anne Ritschel Anne-Katrin Treier Martin Hellmich Veit Roessner Ulrike Ravens-Sieberer Tobias Banaschewski Anja Görtz-Dorten on behalf of the ADOPT Consortium |
| author_facet | Manfred Döpfner Josepha Katzmann Charlotte Hanisch Jörg M. Fegert Michael Kölch Anne Ritschel Anne-Katrin Treier Martin Hellmich Veit Roessner Ulrike Ravens-Sieberer Tobias Banaschewski Anja Görtz-Dorten on behalf of the ADOPT Consortium |
| author_sort | Manfred Döpfner |
| collection | DOAJ |
| description | Abstract Background The terms affective dysregulation (AD) and irritability describe transdiagnostic dimensions and are characterized by an excessive reactivity to negative emotional stimuli with an affective (anger) and a behavioral component (aggression). Due to early onset, high prevalence and persistence, as well as developmental comorbidity, AD in childhood is one of the most psychosocially impairing and cost-intensive mental health conditions. AD is especially prevalent in children in the youth welfare service. Despite continuous research, there remains a substantial need for diagnostic approaches and optimization of individualized treatment strategies in order to improve outcomes and reduce the subjective and economic burden. Methods The ADOPT (Affective Dysregulation – Optimizing Prevention and Treatment) Consortium integrates internationally established, highly experienced and interdisciplinary research groups. The work program encompasses (a) epidemiology, including prevalence of symptoms and disorders, (b) development and evaluation of screening and assessment tools, (c) stepped care approaches for clinically useful personalized medicine, (d) evaluation of an easily accessible and cost-effective online intervention as indicated prevention (treatment effects, moderation/mediation analysis), and (e) evaluation of an intensive personalized modular outpatient treatment in a cohort of children with AD who live with their parents and in a cohort of children with AD who live in out-of-home care (treatment effects, moderation/mediation analysis). Discussion The results will lead to significant recommendations for improving treatment within routine clinical care in two cohorts of children with AD and coexisting conditions, especially oppositional-defiant disorder, conduct disorder and disruptive mood dysregulation disorder. Trial registration Trial registration ADOPT Online: German Clinical Trials Register (DRKS) DRKS00014963. Registered 27 June 2018. Trial registration ADOPT Treatment: German Clinical Trials Register (DRKS) DRKS00013317. Registered 27 September 2018. Trial registration ADOPT Institution: German Clinical Trials Register (DRKS) DRKS00014581. Registered 04 July 2018. |
| first_indexed | 2024-12-11T10:15:52Z |
| format | Article |
| id | doaj.art-a216d7439f1a4da09cebb59b19c3388e |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-11T10:15:52Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-a216d7439f1a4da09cebb59b19c3388e2022-12-22T01:11:37ZengBMCBMC Psychiatry1471-244X2019-09-0119112010.1186/s12888-019-2239-8Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT studyManfred Döpfner0Josepha Katzmann1Charlotte Hanisch2Jörg M. Fegert3Michael Kölch4Anne Ritschel5Anne-Katrin Treier6Martin Hellmich7Veit Roessner8Ulrike Ravens-Sieberer9Tobias Banaschewski10Anja Görtz-Dorten11on behalf of the ADOPT ConsortiumDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty of the University of CologneDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty of the University of CologneFaculty of Human Sciences, University of CologneDepartment of Child and Adolescent Psychiatry/Psychotherapy, University of UlmDepartment of Child and Adolescent Psychiatry/Psychotherapy, University of UlmFaculty of Human Sciences, University of CologneDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty of the University of CologneInstitute of Medical Statistics and Computational Biology (IMSB), Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Child and Adolescent Psychiatry and Psychotherapy, TU DresdenDepartment of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics & Research Unit Child Public Health, University Medical Center Hamburg-EppendorfDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of HeidelbergDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Medical Faculty of the University of CologneAbstract Background The terms affective dysregulation (AD) and irritability describe transdiagnostic dimensions and are characterized by an excessive reactivity to negative emotional stimuli with an affective (anger) and a behavioral component (aggression). Due to early onset, high prevalence and persistence, as well as developmental comorbidity, AD in childhood is one of the most psychosocially impairing and cost-intensive mental health conditions. AD is especially prevalent in children in the youth welfare service. Despite continuous research, there remains a substantial need for diagnostic approaches and optimization of individualized treatment strategies in order to improve outcomes and reduce the subjective and economic burden. Methods The ADOPT (Affective Dysregulation – Optimizing Prevention and Treatment) Consortium integrates internationally established, highly experienced and interdisciplinary research groups. The work program encompasses (a) epidemiology, including prevalence of symptoms and disorders, (b) development and evaluation of screening and assessment tools, (c) stepped care approaches for clinically useful personalized medicine, (d) evaluation of an easily accessible and cost-effective online intervention as indicated prevention (treatment effects, moderation/mediation analysis), and (e) evaluation of an intensive personalized modular outpatient treatment in a cohort of children with AD who live with their parents and in a cohort of children with AD who live in out-of-home care (treatment effects, moderation/mediation analysis). Discussion The results will lead to significant recommendations for improving treatment within routine clinical care in two cohorts of children with AD and coexisting conditions, especially oppositional-defiant disorder, conduct disorder and disruptive mood dysregulation disorder. Trial registration Trial registration ADOPT Online: German Clinical Trials Register (DRKS) DRKS00014963. Registered 27 June 2018. Trial registration ADOPT Treatment: German Clinical Trials Register (DRKS) DRKS00013317. Registered 27 September 2018. Trial registration ADOPT Institution: German Clinical Trials Register (DRKS) DRKS00014581. Registered 04 July 2018.http://link.springer.com/article/10.1186/s12888-019-2239-8Affective dysregulation; disruptive mood dysregulation disorderIrritabilityParent management trainingCognitive behavioral therapyOut-of-home care |
| spellingShingle | Manfred Döpfner Josepha Katzmann Charlotte Hanisch Jörg M. Fegert Michael Kölch Anne Ritschel Anne-Katrin Treier Martin Hellmich Veit Roessner Ulrike Ravens-Sieberer Tobias Banaschewski Anja Görtz-Dorten on behalf of the ADOPT Consortium Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT study BMC Psychiatry Affective dysregulation; disruptive mood dysregulation disorder Irritability Parent management training Cognitive behavioral therapy Out-of-home care |
| title | Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT study |
| title_full | Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT study |
| title_fullStr | Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT study |
| title_full_unstemmed | Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT study |
| title_short | Affective dysregulation in childhood - optimizing prevention and treatment: protocol of three randomized controlled trials in the ADOPT study |
| title_sort | affective dysregulation in childhood optimizing prevention and treatment protocol of three randomized controlled trials in the adopt study |
| topic | Affective dysregulation; disruptive mood dysregulation disorder Irritability Parent management training Cognitive behavioral therapy Out-of-home care |
| url | http://link.springer.com/article/10.1186/s12888-019-2239-8 |
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