Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology
Acne vulgaris of wind-heat in lung meridian is a common skin disease, and there are many traditional Chinese medicine prescriptions, but the mechanism is still not clear. In this paper, the literature on the treatment of acne due to wind-heat in lung meridian and the prescriptions in the patents wer...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2021-01-01
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| Series: | E3S Web of Conferences |
| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/47/e3sconf_icepe2021_03013.pdf |
| _version_ | 1818457917314039808 |
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| author | Yue Yitong Xue Shengping Yue Zhanjun Fang Weijin Li Kang Gao Jiaqi |
| author_facet | Yue Yitong Xue Shengping Yue Zhanjun Fang Weijin Li Kang Gao Jiaqi |
| author_sort | Yue Yitong |
| collection | DOAJ |
| description | Acne vulgaris of wind-heat in lung meridian is a common skin disease, and there are many traditional Chinese medicine prescriptions, but the mechanism is still not clear. In this paper, the literature on the treatment of acne due to wind-heat in lung meridian and the prescriptions in the patents were collected and sorted out in the past twenty years. Excel 2019 was used for medication frequency statistics, and IBM SPSS 25.0 was used for clustering analysis to obtain the core formula. Network pharmacology was used to collect the related targets of drugs and diseases, to construct the action network, and to conduct enrichment analysis. A total of 137 prescriptions and 167 drugs were obtained. The core prescriptions were Cortex mori, Folium eriobotryae, Scutellariae radix, Glycyrrhrizae radix, Fructus gardeniae, Radix rehmanniae, and Cortex moutan. The treatment of acne due to wind-heat in lung meridian should begin with clearing heat, purging the lung, cooling blood and detoxicating. The core prescriptions mainly played a role through AKT1, IL6, TP53, TNF, VEGFA, EGF targets and Kaposi's sarcoma-related herpes virus infection, measles, toxoplasmosis, EB virus infection, IL-17, MAPK and other signaling pathways, so as to provide reference for further clinical research. |
| first_indexed | 2024-12-14T22:50:11Z |
| format | Article |
| id | doaj.art-a216de6edd77406e82c6f39e1910f926 |
| institution | Directory Open Access Journal |
| issn | 2267-1242 |
| language | English |
| last_indexed | 2024-12-14T22:50:11Z |
| publishDate | 2021-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj.art-a216de6edd77406e82c6f39e1910f9262022-12-21T22:44:45ZengEDP SciencesE3S Web of Conferences2267-12422021-01-012710301310.1051/e3sconf/202127103013e3sconf_icepe2021_03013Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacologyYue Yitong0Xue Shengping1Yue Zhanjun2Fang Weijin3Li Kang4Gao Jiaqi5College of Biological Science and Engineering, Hebei University of Economics and BusinessCollege of Biological Science and Engineering, Hebei University of Economics and BusinessYuncheng Zhanjun Hospital of Traditional Chinese MedicineCollege of Biological Science and Engineering, Hebei University of Economics and BusinessCollege of Biological Science and Engineering, Hebei University of Economics and BusinessCollege of Biological Science and Engineering, Hebei University of Economics and BusinessAcne vulgaris of wind-heat in lung meridian is a common skin disease, and there are many traditional Chinese medicine prescriptions, but the mechanism is still not clear. In this paper, the literature on the treatment of acne due to wind-heat in lung meridian and the prescriptions in the patents were collected and sorted out in the past twenty years. Excel 2019 was used for medication frequency statistics, and IBM SPSS 25.0 was used for clustering analysis to obtain the core formula. Network pharmacology was used to collect the related targets of drugs and diseases, to construct the action network, and to conduct enrichment analysis. A total of 137 prescriptions and 167 drugs were obtained. The core prescriptions were Cortex mori, Folium eriobotryae, Scutellariae radix, Glycyrrhrizae radix, Fructus gardeniae, Radix rehmanniae, and Cortex moutan. The treatment of acne due to wind-heat in lung meridian should begin with clearing heat, purging the lung, cooling blood and detoxicating. The core prescriptions mainly played a role through AKT1, IL6, TP53, TNF, VEGFA, EGF targets and Kaposi's sarcoma-related herpes virus infection, measles, toxoplasmosis, EB virus infection, IL-17, MAPK and other signaling pathways, so as to provide reference for further clinical research.https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/47/e3sconf_icepe2021_03013.pdf |
| spellingShingle | Yue Yitong Xue Shengping Yue Zhanjun Fang Weijin Li Kang Gao Jiaqi Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology E3S Web of Conferences |
| title | Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology |
| title_full | Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology |
| title_fullStr | Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology |
| title_full_unstemmed | Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology |
| title_short | Study on traditional Chinese medicine medication for acne of wind-heat type in lung meridian based on data mining and network pharmacology |
| title_sort | study on traditional chinese medicine medication for acne of wind heat type in lung meridian based on data mining and network pharmacology |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2021/47/e3sconf_icepe2021_03013.pdf |
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