PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA
Objective: study of immune status indices in newborns in cases of late detection of cytomegalovirus (CMV) DNA in blood and urine.Methods: 147 newborns with non-specific clinical symptoms were studied. Тyping of lymphocytes relating to different clusters CD3+, CD69+, CD71+, CD95+ using monoclonal a...
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2018-09-01
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| Series: | Детские инфекции (Москва) |
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| Online Access: | https://detinf.elpub.ru/jour/article/view/374 |
| _version_ | 1797881786973290496 |
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| author | L. V. Kravchenko |
| author_facet | L. V. Kravchenko |
| author_sort | L. V. Kravchenko |
| collection | DOAJ |
| description | Objective: study of immune status indices in newborns in cases of late detection of cytomegalovirus (CMV) DNA in blood and urine.Methods: 147 newborns with non-specific clinical symptoms were studied. Тyping of lymphocytes relating to different clusters CD3+, CD69+, CD71+, CD95+ using monoclonal antibodies produced by IMMUNOTECH (France) have been performed. Expression of membrane markers of immunocompetent cells was measured on a laser flow cytofluorometer Beckman COULTER Epics XL II.Results: In 123 newborns CMVI has been confirmed by the positive result of PCR, while in 24 newborns the negative result was obtained. In 24 three-month old babies, who had a negative result following DNA diagnostics in the first month of their life, cytomegalovirus in blood and urine and increase of anti-CMV IgG have been found, which allowed to diagnose CMVI.The following formula reflecting the dependence of CMVI on CD69+ and CD95+ content in newborns having non-specific clinical symptoms in cases of late detection of CMV DNA has been offered. |
| first_indexed | 2024-04-10T03:25:41Z |
| format | Article |
| id | doaj.art-a217a1dbc8484bbdb4d05f93b2b70dc3 |
| institution | Directory Open Access Journal |
| issn | 2072-8107 |
| language | Russian |
| last_indexed | 2024-04-10T03:25:41Z |
| publishDate | 2018-09-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj.art-a217a1dbc8484bbdb4d05f93b2b70dc32023-03-13T07:28:24ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072018-09-01173343710.22627/2072-8107-2018-17-3-34-37350PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNAL. V. Kravchenko0Ростовский государственный медицинский университет МЗ РФObjective: study of immune status indices in newborns in cases of late detection of cytomegalovirus (CMV) DNA in blood and urine.Methods: 147 newborns with non-specific clinical symptoms were studied. Тyping of lymphocytes relating to different clusters CD3+, CD69+, CD71+, CD95+ using monoclonal antibodies produced by IMMUNOTECH (France) have been performed. Expression of membrane markers of immunocompetent cells was measured on a laser flow cytofluorometer Beckman COULTER Epics XL II.Results: In 123 newborns CMVI has been confirmed by the positive result of PCR, while in 24 newborns the negative result was obtained. In 24 three-month old babies, who had a negative result following DNA diagnostics in the first month of their life, cytomegalovirus in blood and urine and increase of anti-CMV IgG have been found, which allowed to diagnose CMVI.The following formula reflecting the dependence of CMVI on CD69+ and CD95+ content in newborns having non-specific clinical symptoms in cases of late detection of CMV DNA has been offered.https://detinf.elpub.ru/jour/article/view/374новорожденныецитомегаловирусная инфекция (цмви)интерферон |
| spellingShingle | L. V. Kravchenko PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA Детские инфекции (Москва) новорожденные цитомегаловирусная инфекция (цмви) интерферон |
| title | PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA |
| title_full | PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA |
| title_fullStr | PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA |
| title_full_unstemmed | PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA |
| title_short | PARAMETERS OF ANTIVIRAL IMMUNITY IN NEWBORNS WITH CYTOMEGALOVIRUS INFECTION IN CASES OF LATE DETECTION OF CYTOMEGALOVIRUS DNA |
| title_sort | parameters of antiviral immunity in newborns with cytomegalovirus infection in cases of late detection of cytomegalovirus dna |
| topic | новорожденные цитомегаловирусная инфекция (цмви) интерферон |
| url | https://detinf.elpub.ru/jour/article/view/374 |
| work_keys_str_mv | AT lvkravchenko parametersofantiviralimmunityinnewbornswithcytomegalovirusinfectionincasesoflatedetectionofcytomegalovirusdna |