Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice

Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice

Abstract Background Obesity and pulmonary hypertension (PH) share common characteristics, such as augmented inflammation and oxidative stress. However, the exact role of obesity in the pathology of PH is largely uninvestigated. Therefore, we have hypothesized that in the context of obesity the gende...

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Main Authors: Balram Neupane, Akylbek Sydykov, Kabita Pradhan, Christina Vroom, Christiane Herden, Srikanth Karnati, Hossein Ardeschir Ghofrani, Sergey Avdeev, Süleyman Ergün, Ralph Theo Schermuly, Djuro Kosanovic
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Respiratory Research
Subjects:
Obesity
Pulmonary hypertension
Zucker rats
Obese B6 mice
Monocrotaline
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12931-020-01394-0

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