Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder
Autism spectrum disorder (ASD) is a neurological disorder with complex etiologies. In this study, urine cells were collected from a 16-year-old male with ASD and reprogrammed with the human SKOM transcription factors. The patient has a heterozygous C > T mutation of FCGR1B gene that was confirmed...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-10-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506119302016 |
| _version_ | 1818142030991196160 |
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| author | Shuai Li Huifang Zhao Rongqi Huang Lang He Chao Tian Hualin Huang Xiaobo Han Feng Tang Zuoxian Lin Sihao Deng Jianda Zhou Zhiyuan Li |
| author_facet | Shuai Li Huifang Zhao Rongqi Huang Lang He Chao Tian Hualin Huang Xiaobo Han Feng Tang Zuoxian Lin Sihao Deng Jianda Zhou Zhiyuan Li |
| author_sort | Shuai Li |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a neurological disorder with complex etiologies. In this study, urine cells were collected from a 16-year-old male with ASD and reprogrammed with the human SKOM transcription factors. The patient has a heterozygous C > T mutation of FCGR1B gene that was confirmed by sequencing analysis. The pluripotency was verified by gene expression and capacity of differentiation towards the three germ layers. This kind of iPSC will be valuable for further understanding the pathogenesis of ASD and help to develop drugs for treating ASD. |
| first_indexed | 2024-12-11T11:09:18Z |
| format | Article |
| id | doaj.art-a217fbbe1a544ae1834a7666859b3b05 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-12-11T11:09:18Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-a217fbbe1a544ae1834a7666859b3b052022-12-22T01:09:37ZengElsevierStem Cell Research1873-50612019-10-0140Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorderShuai Li0Huifang Zhao1Rongqi Huang2Lang He3Chao Tian4Hualin Huang5Xiaobo Han6Feng Tang7Zuoxian Lin8Sihao Deng9Jianda Zhou10Zhiyuan Li11CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell. and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, ChinaSchool of Life Sciences, University of Science and Technology of China, Hefei, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, ChinaCAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell. and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, ChinaDepartment of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaSchool of Life Sciences, University of Science and Technology of China, Hefei, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, ChinaCAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell. and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, ChinaCAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell. and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, ChinaCAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell. and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, ChinaCAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell. and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, ChinaDepartment of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaDepartment of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, ChinaCAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell. and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; School of Life Sciences, University of Science and Technology of China, Hefei, China; GZMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, China; Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China; University of Chinese Academy of Sciences, Beijing 100049, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, 510005 Guangzhou, China; Corresponding author at: CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell. and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.Autism spectrum disorder (ASD) is a neurological disorder with complex etiologies. In this study, urine cells were collected from a 16-year-old male with ASD and reprogrammed with the human SKOM transcription factors. The patient has a heterozygous C > T mutation of FCGR1B gene that was confirmed by sequencing analysis. The pluripotency was verified by gene expression and capacity of differentiation towards the three germ layers. This kind of iPSC will be valuable for further understanding the pathogenesis of ASD and help to develop drugs for treating ASD.http://www.sciencedirect.com/science/article/pii/S1873506119302016 |
| spellingShingle | Shuai Li Huifang Zhao Rongqi Huang Lang He Chao Tian Hualin Huang Xiaobo Han Feng Tang Zuoxian Lin Sihao Deng Jianda Zhou Zhiyuan Li Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder Stem Cell Research |
| title | Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder |
| title_full | Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder |
| title_fullStr | Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder |
| title_full_unstemmed | Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder |
| title_short | Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder |
| title_sort | generation of ipsc line gibhi001 a from a patient with autism spectrum disorder |
| url | http://www.sciencedirect.com/science/article/pii/S1873506119302016 |
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