Retinal microvascular impairment in COVID‐19 patients: A meta‐analysis
Abstract Background The coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to a global pandemic in an unprecedented time frame. Systemic vascular involvement in COVID‐19 has been identified, and SARS‐CoV‐2 has also been found to cause...
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.619 |
| _version_ | 1811254377378217984 |
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| author | Suzhen Wang Jie Wang Jianbin Hu Ningli Wang |
| author_facet | Suzhen Wang Jie Wang Jianbin Hu Ningli Wang |
| author_sort | Suzhen Wang |
| collection | DOAJ |
| description | Abstract Background The coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to a global pandemic in an unprecedented time frame. Systemic vascular involvement in COVID‐19 has been identified, and SARS‐CoV‐2 has also been found to cause multiple organ ischemia and posterior ocular segment disease in mammals, raising concerns about the human retinal microvascular involvement in SARS‐CoV‐2. Objective To objectively assess the presence of retinal microvascular impairment in COVID‐19 patients by optical coherence tomography angiography (OCTA), so as to facilitate the clinical system management of COVID‐19 patients. Methods We searched PubMed, Cochrane Library, EMBASE, Ovid, CBM to collect eligible studies. The main outcomes included the vessel density (VD), area or perimeter of foveal avascular zone (FAZ), central foveal thickness (CFT), subfoveal choroidal thickness (SCT) in our meta‐analysis. Results We eventually included five studies with a total of 401 participants. Our meta‐analysis showed that nonacute infectious COVID‐19 or post‐COVID‐19 patients presented significantly lower foveal VD of deep capillary plexus (WMD = −4.22, 95% CI [−8.00, −0.43]) and thinner SCT (WMD = −10.33, 95% CI [−19.08, −1.57]) than healthy controls. The foveal VD and parafoveal VD of superficial capillary plexus, parafoveal VD of deep capillary plexus, CFT, area, and perimeter of FAZ showed no significant differences between the groups. Conclusion The patients of nonacute infectious COVID‐19 or post‐COVID‐19 displayed alterations in the retinal microvasculature and choroidal vessels, including a significantly lower foveal VD in deep capillary plexus and thinner SCT. The impairment may be a medium to long‐term process. Close ophthalmic surveillance is necessary for COVID‐19 patients or post‐COVID‐19 patients. |
| first_indexed | 2024-04-12T17:06:20Z |
| format | Article |
| id | doaj.art-a21aef6cb6524d98bece2fdf5e740244 |
| institution | Directory Open Access Journal |
| issn | 2050-4527 |
| language | English |
| last_indexed | 2024-04-12T17:06:20Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj.art-a21aef6cb6524d98bece2fdf5e7402442022-12-22T03:23:56ZengWileyImmunity, Inflammation and Disease2050-45272022-06-01106n/an/a10.1002/iid3.619Retinal microvascular impairment in COVID‐19 patients: A meta‐analysisSuzhen Wang0Jie Wang1Jianbin Hu2Ningli Wang3Eye School Chengdu University of Traditional Chinese Medicine Chengdu ChinaAier Eye Hospital (East of Chengdu) Chengdu ChinaAier Eye Hospital (East of Chengdu) Chengdu ChinaEye School Chengdu University of Traditional Chinese Medicine Chengdu ChinaAbstract Background The coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to a global pandemic in an unprecedented time frame. Systemic vascular involvement in COVID‐19 has been identified, and SARS‐CoV‐2 has also been found to cause multiple organ ischemia and posterior ocular segment disease in mammals, raising concerns about the human retinal microvascular involvement in SARS‐CoV‐2. Objective To objectively assess the presence of retinal microvascular impairment in COVID‐19 patients by optical coherence tomography angiography (OCTA), so as to facilitate the clinical system management of COVID‐19 patients. Methods We searched PubMed, Cochrane Library, EMBASE, Ovid, CBM to collect eligible studies. The main outcomes included the vessel density (VD), area or perimeter of foveal avascular zone (FAZ), central foveal thickness (CFT), subfoveal choroidal thickness (SCT) in our meta‐analysis. Results We eventually included five studies with a total of 401 participants. Our meta‐analysis showed that nonacute infectious COVID‐19 or post‐COVID‐19 patients presented significantly lower foveal VD of deep capillary plexus (WMD = −4.22, 95% CI [−8.00, −0.43]) and thinner SCT (WMD = −10.33, 95% CI [−19.08, −1.57]) than healthy controls. The foveal VD and parafoveal VD of superficial capillary plexus, parafoveal VD of deep capillary plexus, CFT, area, and perimeter of FAZ showed no significant differences between the groups. Conclusion The patients of nonacute infectious COVID‐19 or post‐COVID‐19 displayed alterations in the retinal microvasculature and choroidal vessels, including a significantly lower foveal VD in deep capillary plexus and thinner SCT. The impairment may be a medium to long‐term process. Close ophthalmic surveillance is necessary for COVID‐19 patients or post‐COVID‐19 patients.https://doi.org/10.1002/iid3.619COVID‐19optical coherence tomography angiographyretinal microvascularSARS‐CoV‐2vessel density |
| spellingShingle | Suzhen Wang Jie Wang Jianbin Hu Ningli Wang Retinal microvascular impairment in COVID‐19 patients: A meta‐analysis Immunity, Inflammation and Disease COVID‐19 optical coherence tomography angiography retinal microvascular SARS‐CoV‐2 vessel density |
| title | Retinal microvascular impairment in COVID‐19 patients: A meta‐analysis |
| title_full | Retinal microvascular impairment in COVID‐19 patients: A meta‐analysis |
| title_fullStr | Retinal microvascular impairment in COVID‐19 patients: A meta‐analysis |
| title_full_unstemmed | Retinal microvascular impairment in COVID‐19 patients: A meta‐analysis |
| title_short | Retinal microvascular impairment in COVID‐19 patients: A meta‐analysis |
| title_sort | retinal microvascular impairment in covid 19 patients a meta analysis |
| topic | COVID‐19 optical coherence tomography angiography retinal microvascular SARS‐CoV‐2 vessel density |
| url | https://doi.org/10.1002/iid3.619 |
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