Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma.
BACKGROUND:In patients with advanced non-small-cell lung cancer, vitamin D receptor (VDR) polymorphisms and haplotypes are reported to be associated with survival. We hypothesized that a similar association would be observed in patients with head and neck squamous-cell carcinoma (HNSCC). METHODS:In...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3248455?pdf=render |
| _version_ | 1818581768846966784 |
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| author | Takanori Hama Chihiro Norizoe Hiroaki Suga Takeshi Mimura Takakuni Kato Hiroshi Moriyama Mitsuyoshi Urashima |
| author_facet | Takanori Hama Chihiro Norizoe Hiroaki Suga Takeshi Mimura Takakuni Kato Hiroshi Moriyama Mitsuyoshi Urashima |
| author_sort | Takanori Hama |
| collection | DOAJ |
| description | BACKGROUND:In patients with advanced non-small-cell lung cancer, vitamin D receptor (VDR) polymorphisms and haplotypes are reported to be associated with survival. We hypothesized that a similar association would be observed in patients with head and neck squamous-cell carcinoma (HNSCC). METHODS:In a post-hoc analysis of our previous prospective cohort study, VDR polymorphisms including Cdx2 G/A (rs11568820), FokI C/T (rs10735810), BsmI A/G (rs1544410), ApaI G/T (rs7976091), and TaqI T/C (rs731236) were genotyped by sequencing in 204 consecutive patients with HNSCC who underwent tumor resection. Progression-free survival was compared between VDR polymorphisms using Kaplan-Meier survival curves with log-rank tests and Cox proportional hazard models adjusting for age, gender, smoking status, primary tumor sites, postoperative stages, existence of residual tumor, and postoperative treatment with chemotherapy or radiotherapy. RESULTS:During a median follow-up of 1,047 days, tumor progression and death occurred in 76 (37.3%) and 27 (13.2%) patients, respectively. The FokI T/T genotype was associated with poor progression-free survival: median survival for T/T was 265 days compared with 1,127 days for C/C or C/T (log-rank test: P = 0.0004; adjusted hazard ratio, 3.03; 95% confidence interval, 1.62 to 5.67; P = 0.001). In contrast, the other polymorphisms (Cdx2, BsmI, ApaI, TaqI) showed no significant association with progression-free survival. The A-T-G (Cdx2-FokI-ApaI) haplotype demonstrated a significant association with a higher progression rate (P = 0.02). CONCLUSION:These results suggest that VDR polymorphisms and haplotypes may be associated with prognosis in patients with HNSCC, although the sample size is not large enough to draw definitive conclusions. |
| first_indexed | 2024-12-16T07:38:45Z |
| format | Article |
| id | doaj.art-a21d98fdcdc94a90997b752c03df8c63 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T07:38:45Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-a21d98fdcdc94a90997b752c03df8c632022-12-21T22:39:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01612e2963410.1371/journal.pone.0029634Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma.Takanori HamaChihiro NorizoeHiroaki SugaTakeshi MimuraTakakuni KatoHiroshi MoriyamaMitsuyoshi UrashimaBACKGROUND:In patients with advanced non-small-cell lung cancer, vitamin D receptor (VDR) polymorphisms and haplotypes are reported to be associated with survival. We hypothesized that a similar association would be observed in patients with head and neck squamous-cell carcinoma (HNSCC). METHODS:In a post-hoc analysis of our previous prospective cohort study, VDR polymorphisms including Cdx2 G/A (rs11568820), FokI C/T (rs10735810), BsmI A/G (rs1544410), ApaI G/T (rs7976091), and TaqI T/C (rs731236) were genotyped by sequencing in 204 consecutive patients with HNSCC who underwent tumor resection. Progression-free survival was compared between VDR polymorphisms using Kaplan-Meier survival curves with log-rank tests and Cox proportional hazard models adjusting for age, gender, smoking status, primary tumor sites, postoperative stages, existence of residual tumor, and postoperative treatment with chemotherapy or radiotherapy. RESULTS:During a median follow-up of 1,047 days, tumor progression and death occurred in 76 (37.3%) and 27 (13.2%) patients, respectively. The FokI T/T genotype was associated with poor progression-free survival: median survival for T/T was 265 days compared with 1,127 days for C/C or C/T (log-rank test: P = 0.0004; adjusted hazard ratio, 3.03; 95% confidence interval, 1.62 to 5.67; P = 0.001). In contrast, the other polymorphisms (Cdx2, BsmI, ApaI, TaqI) showed no significant association with progression-free survival. The A-T-G (Cdx2-FokI-ApaI) haplotype demonstrated a significant association with a higher progression rate (P = 0.02). CONCLUSION:These results suggest that VDR polymorphisms and haplotypes may be associated with prognosis in patients with HNSCC, although the sample size is not large enough to draw definitive conclusions.http://europepmc.org/articles/PMC3248455?pdf=render |
| spellingShingle | Takanori Hama Chihiro Norizoe Hiroaki Suga Takeshi Mimura Takakuni Kato Hiroshi Moriyama Mitsuyoshi Urashima Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma. PLoS ONE |
| title | Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma. |
| title_full | Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma. |
| title_fullStr | Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma. |
| title_full_unstemmed | Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma. |
| title_short | Prognostic significance of vitamin D receptor polymorphisms in head and neck squamous cell carcinoma. |
| title_sort | prognostic significance of vitamin d receptor polymorphisms in head and neck squamous cell carcinoma |
| url | http://europepmc.org/articles/PMC3248455?pdf=render |
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