Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis
Background:Salvia miltiorrhiza Bunge. [Lamiaceae, danshen] injection classes (SMIC) is widely used in the treatment of unstable angina (UA). However, it is uncertain which SMIC is more effective in terms of UA efficacy. The purpose of this Network Meta-analysis (NMA) was to compare the treatment eff...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.972738/full |
| _version_ | 1811205061451186176 |
|---|---|
| author | Mingxuan Li Mingxuan Li Hongdian Li Hongxu Liu Xiaolei Lai Wenlong Xing |
| author_facet | Mingxuan Li Mingxuan Li Hongdian Li Hongxu Liu Xiaolei Lai Wenlong Xing |
| author_sort | Mingxuan Li |
| collection | DOAJ |
| description | Background:Salvia miltiorrhiza Bunge. [Lamiaceae, danshen] injection classes (SMIC) is widely used in the treatment of unstable angina (UA). However, it is uncertain which SMIC is more effective in terms of UA efficacy. The purpose of this Network Meta-analysis (NMA) was to compare the treatment effects of various SMIC to determine the best SMIC for the treatment of UA.Methods: The China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), Chinese Biomedical Literature Database (CBM), PubMed, Web of Science, and Cochrane Library databases were searched to screen randomized controlled trials (RCTs) of SMIC for UA. The search time frame was all from the establishment of the database to May 2022. RevMan 5.3 and Stata 14.0 software were used for NMA.Results: A total of 148 studies including 14,979 patients, including 7,584 cases in the experimental group and 7,395 cases in the control group were included, and eight SMIC were extracted, namely:Danshen injection, Fufang Danshen injection, Guanxinning injection, Danshenchuanxiongqin injection, Danhong injection, Danshentong IIA Huangsuanna injection, Shenxiong Putaotang injection, and Danshenduofensuanyan injection. The results of NMA showed that, in terms of total effective rate, Shenxiong Putaotang injection and Danshenchuanxiongqin injection have the advantage; In terms of ECG efficiency, Danshentong IIA Huangsuanna injection and Danshen injection have an advantage; Danshenchuanxiongqin injection and Danshenduofensuanyan injection were more effective than other SMIC in improving angina pectoris attacks; Shenxiong Putaotang injection has an advantage in improving hs-CRP; Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection have advantages in improving TC and TG, respectively.Conclusion: The eight SMIC included in the current study were effective in treating UA, Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection were both superior in improving all outcome indicators. However, there is still a need for larger samples and high-quality randomized controlled trials for more refined comparisons of various SMIC.Systematic Review Registration: [PROSPERO], identifier [CRD42022350872] |
| first_indexed | 2024-04-12T03:24:18Z |
| format | Article |
| id | doaj.art-a21e4af0c8f848828781f303b6a45943 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T03:24:18Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a21e4af0c8f848828781f303b6a459432022-12-22T03:49:46ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-10-011310.3389/fphar.2022.972738972738Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysisMingxuan Li0Mingxuan Li1Hongdian Li2Hongxu Liu3Xiaolei Lai4Wenlong Xing5Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaBeijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, ChinaBackground:Salvia miltiorrhiza Bunge. [Lamiaceae, danshen] injection classes (SMIC) is widely used in the treatment of unstable angina (UA). However, it is uncertain which SMIC is more effective in terms of UA efficacy. The purpose of this Network Meta-analysis (NMA) was to compare the treatment effects of various SMIC to determine the best SMIC for the treatment of UA.Methods: The China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), Chinese Biomedical Literature Database (CBM), PubMed, Web of Science, and Cochrane Library databases were searched to screen randomized controlled trials (RCTs) of SMIC for UA. The search time frame was all from the establishment of the database to May 2022. RevMan 5.3 and Stata 14.0 software were used for NMA.Results: A total of 148 studies including 14,979 patients, including 7,584 cases in the experimental group and 7,395 cases in the control group were included, and eight SMIC were extracted, namely:Danshen injection, Fufang Danshen injection, Guanxinning injection, Danshenchuanxiongqin injection, Danhong injection, Danshentong IIA Huangsuanna injection, Shenxiong Putaotang injection, and Danshenduofensuanyan injection. The results of NMA showed that, in terms of total effective rate, Shenxiong Putaotang injection and Danshenchuanxiongqin injection have the advantage; In terms of ECG efficiency, Danshentong IIA Huangsuanna injection and Danshen injection have an advantage; Danshenchuanxiongqin injection and Danshenduofensuanyan injection were more effective than other SMIC in improving angina pectoris attacks; Shenxiong Putaotang injection has an advantage in improving hs-CRP; Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection have advantages in improving TC and TG, respectively.Conclusion: The eight SMIC included in the current study were effective in treating UA, Shenxiong Putaotang injection and Danshentong IIA Huangsuanna injection were both superior in improving all outcome indicators. However, there is still a need for larger samples and high-quality randomized controlled trials for more refined comparisons of various SMIC.Systematic Review Registration: [PROSPERO], identifier [CRD42022350872]https://www.frontiersin.org/articles/10.3389/fphar.2022.972738/fullTraditional Chinese Medicineunstable angina (UA)network meta-analysisSalvia miltiorrhiza injection classesChinese medicine injection |
| spellingShingle | Mingxuan Li Mingxuan Li Hongdian Li Hongxu Liu Xiaolei Lai Wenlong Xing Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis Frontiers in Pharmacology Traditional Chinese Medicine unstable angina (UA) network meta-analysis Salvia miltiorrhiza injection classes Chinese medicine injection |
| title | Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis |
| title_full | Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis |
| title_fullStr | Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis |
| title_full_unstemmed | Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis |
| title_short | Efficacy and safety of eight types Salvia miltiorrhiza injections in the treatment of unstable angina pectoris: A network meta-analysis |
| title_sort | efficacy and safety of eight types salvia miltiorrhiza injections in the treatment of unstable angina pectoris a network meta analysis |
| topic | Traditional Chinese Medicine unstable angina (UA) network meta-analysis Salvia miltiorrhiza injection classes Chinese medicine injection |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.972738/full |
| work_keys_str_mv | AT mingxuanli efficacyandsafetyofeighttypessalviamiltiorrhizainjectionsinthetreatmentofunstableanginapectorisanetworkmetaanalysis AT mingxuanli efficacyandsafetyofeighttypessalviamiltiorrhizainjectionsinthetreatmentofunstableanginapectorisanetworkmetaanalysis AT hongdianli efficacyandsafetyofeighttypessalviamiltiorrhizainjectionsinthetreatmentofunstableanginapectorisanetworkmetaanalysis AT hongxuliu efficacyandsafetyofeighttypessalviamiltiorrhizainjectionsinthetreatmentofunstableanginapectorisanetworkmetaanalysis AT xiaoleilai efficacyandsafetyofeighttypessalviamiltiorrhizainjectionsinthetreatmentofunstableanginapectorisanetworkmetaanalysis AT wenlongxing efficacyandsafetyofeighttypessalviamiltiorrhizainjectionsinthetreatmentofunstableanginapectorisanetworkmetaanalysis |