Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges
Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in human neonates, and is often associated with persistent motor, sensory, and cognitive impairment. Improved intensive care technology has increased survival without preventing neurological disorder, increasing morbidi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-05-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fncel.2017.00078/full |
| _version_ | 1819034272838713344 |
|---|---|
| author | Lancelot J. Millar Lei Shi Lei Shi Anna Hoerder-Suabedissen Zoltán Molnár |
| author_facet | Lancelot J. Millar Lei Shi Lei Shi Anna Hoerder-Suabedissen Zoltán Molnár |
| author_sort | Lancelot J. Millar |
| collection | DOAJ |
| description | Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in human neonates, and is often associated with persistent motor, sensory, and cognitive impairment. Improved intensive care technology has increased survival without preventing neurological disorder, increasing morbidity throughout the adult population. Early preventative or neuroprotective interventions have the potential to rescue brain development in neonates, yet only one therapeutic intervention is currently licensed for use in developed countries. Recent investigations of the transient cortical layer known as subplate, especially regarding subplate’s secretory role, opens up a novel set of potential molecular modulators of neonatal HI injury. This review examines the biological mechanisms of human neonatal HI, discusses evidence for the relevance of subplate-secreted molecules to this condition, and evaluates available animal models. Neuroserpin, a neuronally released neuroprotective factor, is discussed as a case study for developing new potential pharmacological interventions for use post-ischaemic injury. |
| first_indexed | 2024-12-21T07:31:06Z |
| format | Article |
| id | doaj.art-a21ff7b71d6544cebaf39fa08f242ab0 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-21T07:31:06Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-a21ff7b71d6544cebaf39fa08f242ab02022-12-21T19:11:34ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022017-05-011110.3389/fncel.2017.00078239973Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic ChallengesLancelot J. Millar0Lei Shi1Lei Shi2Anna Hoerder-Suabedissen3Zoltán Molnár4Molnár Group, Department of Physiology, Anatomy and Genetics, University of OxfordOxford, UKMolnár Group, Department of Physiology, Anatomy and Genetics, University of OxfordOxford, UKJNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, College of Pharmacy, Jinan UniversityGuangzhou, ChinaMolnár Group, Department of Physiology, Anatomy and Genetics, University of OxfordOxford, UKMolnár Group, Department of Physiology, Anatomy and Genetics, University of OxfordOxford, UKNeonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in human neonates, and is often associated with persistent motor, sensory, and cognitive impairment. Improved intensive care technology has increased survival without preventing neurological disorder, increasing morbidity throughout the adult population. Early preventative or neuroprotective interventions have the potential to rescue brain development in neonates, yet only one therapeutic intervention is currently licensed for use in developed countries. Recent investigations of the transient cortical layer known as subplate, especially regarding subplate’s secretory role, opens up a novel set of potential molecular modulators of neonatal HI injury. This review examines the biological mechanisms of human neonatal HI, discusses evidence for the relevance of subplate-secreted molecules to this condition, and evaluates available animal models. Neuroserpin, a neuronally released neuroprotective factor, is discussed as a case study for developing new potential pharmacological interventions for use post-ischaemic injury.http://journal.frontiersin.org/article/10.3389/fncel.2017.00078/fullneonatalhypoxia-ischemiaencephalopathysubplateneurodevelopmentneuroserpin |
| spellingShingle | Lancelot J. Millar Lei Shi Lei Shi Anna Hoerder-Suabedissen Zoltán Molnár Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges Frontiers in Cellular Neuroscience neonatal hypoxia-ischemia encephalopathy subplate neurodevelopment neuroserpin |
| title | Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges |
| title_full | Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges |
| title_fullStr | Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges |
| title_full_unstemmed | Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges |
| title_short | Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges |
| title_sort | neonatal hypoxia ischaemia mechanisms models and therapeutic challenges |
| topic | neonatal hypoxia-ischemia encephalopathy subplate neurodevelopment neuroserpin |
| url | http://journal.frontiersin.org/article/10.3389/fncel.2017.00078/full |
| work_keys_str_mv | AT lancelotjmillar neonatalhypoxiaischaemiamechanismsmodelsandtherapeuticchallenges AT leishi neonatalhypoxiaischaemiamechanismsmodelsandtherapeuticchallenges AT leishi neonatalhypoxiaischaemiamechanismsmodelsandtherapeuticchallenges AT annahoerdersuabedissen neonatalhypoxiaischaemiamechanismsmodelsandtherapeuticchallenges AT zoltanmolnar neonatalhypoxiaischaemiamechanismsmodelsandtherapeuticchallenges |