Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment Table
The COMEX-30 hyperbaric treatment table is used to manage decompression sickness in divers but may result in pulmonary oxygen toxicity (POT). Volatile organic compounds (VOCs) in exhaled breath are early markers of hyperoxic stress that may be linked to POT. The present study assessed whether VOCs f...
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MDPI AG
2023-02-01
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| Online Access: | https://www.mdpi.com/2218-1989/13/3/316 |
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| author | Feiko J. M. de Jong Thijs T. Wingelaar Paul Brinkman Pieter-Jan A. M. van Ooij Anke H. Maitland-van der Zee Markus W. Hollmann Rob A. van Hulst |
| author_facet | Feiko J. M. de Jong Thijs T. Wingelaar Paul Brinkman Pieter-Jan A. M. van Ooij Anke H. Maitland-van der Zee Markus W. Hollmann Rob A. van Hulst |
| author_sort | Feiko J. M. de Jong |
| collection | DOAJ |
| description | The COMEX-30 hyperbaric treatment table is used to manage decompression sickness in divers but may result in pulmonary oxygen toxicity (POT). Volatile organic compounds (VOCs) in exhaled breath are early markers of hyperoxic stress that may be linked to POT. The present study assessed whether VOCs following COMEX-30 treatment are early markers of hyperoxic stress and/or POT in ten healthy, nonsmoking volunteers. Because more oxygen is inhaled during COMEX-30 treatment than with other treatment tables, this study hypothesized that VOCs exhaled following COMEX-30 treatment are indicators of POT. Breath samples were collected before and 0.5, 2, and 4 h after COMEX-30 treatment. All subjects were followed-up for signs of POT or other symptoms. Nine compounds were identified, with four (nonanal, decanal, ethyl acetate, and tridecane) increasing 33–500% in intensity from before to after COMEX-30 treatment. Seven subjects reported pulmonary symptoms, five reported out-of-proportion tiredness and transient ear fullness, and four had signs of mild dehydration. All VOCs identified following COMEX-30 treatment have been associated with inflammatory responses or pulmonary diseases, such as asthma or lung cancer. Because most subjects reported transient pulmonary symptoms reflecting early-stage POT, the identified VOCs are likely markers of POT, not just hyperbaric hyperoxic exposure. |
| first_indexed | 2024-03-11T06:11:29Z |
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| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T06:11:29Z |
| publishDate | 2023-02-01 |
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| series | Metabolites |
| spelling | doaj.art-a220f76671b44a09887e72f25b1feabb2023-11-17T12:35:46ZengMDPI AGMetabolites2218-19892023-02-0113331610.3390/metabo13030316Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment TableFeiko J. M. de Jong0Thijs T. Wingelaar1Paul Brinkman2Pieter-Jan A. M. van Ooij3Anke H. Maitland-van der Zee4Markus W. Hollmann5Rob A. van Hulst6Royal Netherlands Navy Diving and Submarine Medical Centre, 1780 CA Den Helder, The NetherlandsRoyal Netherlands Navy Diving and Submarine Medical Centre, 1780 CA Den Helder, The NetherlandsDepartment of Pulmonology, Amsterdam UMC, Location AMC, 1100 DD Amsterdam, The NetherlandsRoyal Netherlands Navy Diving and Submarine Medical Centre, 1780 CA Den Helder, The NetherlandsDepartment of Pulmonology, Amsterdam UMC, Location AMC, 1100 DD Amsterdam, The NetherlandsDepartment of Anesthesiology, Amsterdam UMC, Location AMC, 1100 DD Amsterdam, The NetherlandsDepartment of Anesthesiology, Amsterdam UMC, Location AMC, 1100 DD Amsterdam, The NetherlandsThe COMEX-30 hyperbaric treatment table is used to manage decompression sickness in divers but may result in pulmonary oxygen toxicity (POT). Volatile organic compounds (VOCs) in exhaled breath are early markers of hyperoxic stress that may be linked to POT. The present study assessed whether VOCs following COMEX-30 treatment are early markers of hyperoxic stress and/or POT in ten healthy, nonsmoking volunteers. Because more oxygen is inhaled during COMEX-30 treatment than with other treatment tables, this study hypothesized that VOCs exhaled following COMEX-30 treatment are indicators of POT. Breath samples were collected before and 0.5, 2, and 4 h after COMEX-30 treatment. All subjects were followed-up for signs of POT or other symptoms. Nine compounds were identified, with four (nonanal, decanal, ethyl acetate, and tridecane) increasing 33–500% in intensity from before to after COMEX-30 treatment. Seven subjects reported pulmonary symptoms, five reported out-of-proportion tiredness and transient ear fullness, and four had signs of mild dehydration. All VOCs identified following COMEX-30 treatment have been associated with inflammatory responses or pulmonary diseases, such as asthma or lung cancer. Because most subjects reported transient pulmonary symptoms reflecting early-stage POT, the identified VOCs are likely markers of POT, not just hyperbaric hyperoxic exposure.https://www.mdpi.com/2218-1989/13/3/316hyperbaric oxygen therapyhyperoxiapulmonary oxygen toxicityexhaled breath markersvolatile organic compoundsCOMEX-30 |
| spellingShingle | Feiko J. M. de Jong Thijs T. Wingelaar Paul Brinkman Pieter-Jan A. M. van Ooij Anke H. Maitland-van der Zee Markus W. Hollmann Rob A. van Hulst Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment Table Metabolites hyperbaric oxygen therapy hyperoxia pulmonary oxygen toxicity exhaled breath markers volatile organic compounds COMEX-30 |
| title | Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment Table |
| title_full | Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment Table |
| title_fullStr | Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment Table |
| title_full_unstemmed | Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment Table |
| title_short | Analysis of Volatile Organic Compounds in Exhaled Breath Following a COMEX-30 Treatment Table |
| title_sort | analysis of volatile organic compounds in exhaled breath following a comex 30 treatment table |
| topic | hyperbaric oxygen therapy hyperoxia pulmonary oxygen toxicity exhaled breath markers volatile organic compounds COMEX-30 |
| url | https://www.mdpi.com/2218-1989/13/3/316 |
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