Association between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in Colombia
Cyclin dependent kinase inhibitor (CDKN) 2A/B deletion is correlated with poor risk factors, such as high blood cell count, higher rate of induction therapy failure, and earlier relapses in pediatric patients with acute lymphoblastic leukemia (ALL). The frequency of CDKN2A/B deletion in the Hispanic...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Pediatric Hematology Oncology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468124522000079 |
| _version_ | 1818141951578341376 |
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| author | Cindy Martinez Luz Karime Yunis Edgar Cabrera Johnny García Gloria Uribe Edna Quintero Juan Jose Yunis Adriana Linares Ballesteros Isabel Cristina Sarmiento |
| author_facet | Cindy Martinez Luz Karime Yunis Edgar Cabrera Johnny García Gloria Uribe Edna Quintero Juan Jose Yunis Adriana Linares Ballesteros Isabel Cristina Sarmiento |
| author_sort | Cindy Martinez |
| collection | DOAJ |
| description | Cyclin dependent kinase inhibitor (CDKN) 2A/B deletion is correlated with poor risk factors, such as high blood cell count, higher rate of induction therapy failure, and earlier relapses in pediatric patients with acute lymphoblastic leukemia (ALL). The frequency of CDKN2A/B deletion in the Hispanic population is not known. This study aimed to identify the frequency of CDKN2A/B deletion and explore the association of CDKN2A/B deletion with poor prognostic factors in Colombian pediatric patients with pre-B-ALL. One hundred and sixteen patients were included. Twenty-nine patients (25%) had CDKN2A/B deletion. CDKN2A/B deletions were associated with poor prognostic markers in this cohort. |
| first_indexed | 2024-12-11T11:08:02Z |
| format | Article |
| id | doaj.art-a2216a2ee71e420c806703427e1286ac |
| institution | Directory Open Access Journal |
| issn | 2468-1245 |
| language | English |
| last_indexed | 2024-12-11T11:08:02Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatric Hematology Oncology Journal |
| spelling | doaj.art-a2216a2ee71e420c806703427e1286ac2022-12-22T01:09:39ZengElsevierPediatric Hematology Oncology Journal2468-12452022-03-017113Association between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in ColombiaCindy Martinez0Luz Karime Yunis1Edgar Cabrera2Johnny García3Gloria Uribe4Edna Quintero5Juan Jose Yunis6Adriana Linares Ballesteros7Isabel Cristina Sarmiento8Grupo de Oncohematología Pediátrica, Departamento de Pediatría, Universidad Nacional de Colombia- Fundación Hospital Pediátrico La Misericordia, Bogotá D.C., ColombiaGrupo de Patología Molecular, Universidad Nacional de Colombia, Bogotá D.C., Colombia; Servicios Médicos Yunis Turbay y Cía SAS Instituto de Genética, Bogotá D.C., Colombia; Corresponding author. Calle 86B No 49D-28 Oficina 303, Bogotá, Colombia.Pediatric Hematology/Oncology Unit, Fundación Hospital Pediátrico La Misericordia, Bogotá D.C., ColombiaPediatric Hematology/Oncology Unit, Fundación Hospital Pediátrico La Misericordia, Bogotá D.C., ColombiaPathology Unit, Fundación Hospital Pediátrico La Misericordia, Bogotá D.C., ColombiaPathology Unit, Fundación Hospital Pediátrico La Misericordia, Bogotá D.C., ColombiaGrupo de Patología Molecular, Universidad Nacional de Colombia, Bogotá D.C., Colombia; Servicios Médicos Yunis Turbay y Cía SAS Instituto de Genética, Bogotá D.C., Colombia; Departamento de Patología, Facultad de Medicina e Instituto de Genética, Universidad Nacional de Colombia, Bogotá D.C., ColombiaGrupo de Oncohematología Pediátrica, Departamento de Pediatría, Universidad Nacional de Colombia- Fundación Hospital Pediátrico La Misericordia, Bogotá D.C., Colombia; Pediatric Hematology/Oncology Unit, Fundación Hospital Pediátrico La Misericordia, Bogotá D.C., ColombiaGrupo de Oncohematología Pediátrica, Departamento de Pediatría, Universidad Nacional de Colombia- Fundación Hospital Pediátrico La Misericordia, Bogotá D.C., ColombiaCyclin dependent kinase inhibitor (CDKN) 2A/B deletion is correlated with poor risk factors, such as high blood cell count, higher rate of induction therapy failure, and earlier relapses in pediatric patients with acute lymphoblastic leukemia (ALL). The frequency of CDKN2A/B deletion in the Hispanic population is not known. This study aimed to identify the frequency of CDKN2A/B deletion and explore the association of CDKN2A/B deletion with poor prognostic factors in Colombian pediatric patients with pre-B-ALL. One hundred and sixteen patients were included. Twenty-nine patients (25%) had CDKN2A/B deletion. CDKN2A/B deletions were associated with poor prognostic markers in this cohort.http://www.sciencedirect.com/science/article/pii/S2468124522000079Acute lymphoblastic leukemiaMLPACDKN2A/B deletionPediatrics |
| spellingShingle | Cindy Martinez Luz Karime Yunis Edgar Cabrera Johnny García Gloria Uribe Edna Quintero Juan Jose Yunis Adriana Linares Ballesteros Isabel Cristina Sarmiento Association between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in Colombia Pediatric Hematology Oncology Journal Acute lymphoblastic leukemia MLPA CDKN2A/B deletion Pediatrics |
| title | Association between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in Colombia |
| title_full | Association between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in Colombia |
| title_fullStr | Association between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in Colombia |
| title_full_unstemmed | Association between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in Colombia |
| title_short | Association between early risk factors and CDKN2A/B deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in Colombia |
| title_sort | association between early risk factors and cdkn2a b deletion in pediatric patients with acute lymphoblastic leukemia in a pediatric cancer center in colombia |
| topic | Acute lymphoblastic leukemia MLPA CDKN2A/B deletion Pediatrics |
| url | http://www.sciencedirect.com/science/article/pii/S2468124522000079 |
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