The genome-wide mutational consequences of DNA hypomethylation
Abstract DNA methylation is important for establishing and maintaining cell identity and for genomic stability. This is achieved by regulating the accessibility of regulatory and transcriptional elements and the compaction of subtelomeric, centromeric, and other inactive genomic regions. Carcinogene...
Main Authors: | Nicolle Besselink, Janneke Keijer, Carlo Vermeulen, Sander Boymans, Jeroen de Ridder, Arne van Hoeck, Edwin Cuppen, Ewart Kuijk |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-04-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-33932-3 |
Similar Items
-
The mutational impact of culturing human pluripotent and adult stem cells
by: Ewart Kuijk, et al.
Published: (2020-05-01) -
Publisher Correction: The mutational impact of culturing human pluripotent and adult stem cells
by: Ewart Kuijk, et al.
Published: (2020-08-01) -
Common anti-cancer therapies induce somatic mutations in stem cells of healthy tissue
by: Ewart Kuijk, et al.
Published: (2022-10-01) -
Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features
by: Luan Nguyen, et al.
Published: (2022-07-01) -
Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer
by: Judith M. Vlaar, et al.
Published: (2022-06-01)