Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study
This study examined treatment outcomes, including preserved fertility, menstrual regularity, and pregnancy outcomes, in patients with stage I epithelial ovarian cancer (EOC) or borderline ovarian tumors (BOTs) who underwent fertility-sparing surgery (FSS). Patients with stage I EOC and BOTs who were...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/22/5327 |
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| author | Mu-En Ko Yi-Heng Lin Kuan-Ju Huang Wen-Chun Chang Bor-Ching Sheu |
| author_facet | Mu-En Ko Yi-Heng Lin Kuan-Ju Huang Wen-Chun Chang Bor-Ching Sheu |
| author_sort | Mu-En Ko |
| collection | DOAJ |
| description | This study examined treatment outcomes, including preserved fertility, menstrual regularity, and pregnancy outcomes, in patients with stage I epithelial ovarian cancer (EOC) or borderline ovarian tumors (BOTs) who underwent fertility-sparing surgery (FSS). Patients with stage I EOC and BOTs who were aged 18–45 years and underwent FSS between 2007 and 2022 were retrospectively reviewed. Significant differences between various subgroups in terms of disease recurrence, menstrual irregularity due to the disease, and pregnancy outcomes were analyzed. A total of 71 patients with BOTs and 33 patients with EOC were included. In the BOT group, the median age was 30 (range, 19–44) years. Recurrence occurred in eight patients, with one case exhibiting a malignant transformation into mucinous EOC. Among the 35 married patients with BOTs, 20 successfully conceived, resulting in 23 live births and 3 spontaneous abortions. A higher pregnancy rate was observed in those without prior childbirth (82.4%) than in those who had prior childbirth (33.3%). In the EOC group, the median age was 34 (range, 22–42) years. Recurrence occurred in one patient. Menstrual regularity was maintained in 69.7% of the patients. Among the 14 married patients in this group, 12 achieved a total of 15 pregnancies (including 2 twin pregnancies), 16 live births, and 1 spontaneous abortion. The results of the study confirmed that FSS is a favorable surgical option for young women with early-stage BOTs or EOC who wish to preserve their fertility. However, additional investigations are needed to validate these findings. |
| first_indexed | 2024-03-09T16:57:52Z |
| format | Article |
| id | doaj.art-a22316a652f7403a9daf1e0d46bd4f43 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T16:57:52Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a22316a652f7403a9daf1e0d46bd4f432023-11-24T14:33:58ZengMDPI AGCancers2072-66942023-11-011522532710.3390/cancers15225327Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center StudyMu-En Ko0Yi-Heng Lin1Kuan-Ju Huang2Wen-Chun Chang3Bor-Ching Sheu4Department of Obstetrics and Gynecology, National Taiwan University Hospital Yunlin Branch, Yunlin 640, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital Yunlin Branch, Yunlin 640, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei 100, TaiwanDepartment of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei 100, TaiwanThis study examined treatment outcomes, including preserved fertility, menstrual regularity, and pregnancy outcomes, in patients with stage I epithelial ovarian cancer (EOC) or borderline ovarian tumors (BOTs) who underwent fertility-sparing surgery (FSS). Patients with stage I EOC and BOTs who were aged 18–45 years and underwent FSS between 2007 and 2022 were retrospectively reviewed. Significant differences between various subgroups in terms of disease recurrence, menstrual irregularity due to the disease, and pregnancy outcomes were analyzed. A total of 71 patients with BOTs and 33 patients with EOC were included. In the BOT group, the median age was 30 (range, 19–44) years. Recurrence occurred in eight patients, with one case exhibiting a malignant transformation into mucinous EOC. Among the 35 married patients with BOTs, 20 successfully conceived, resulting in 23 live births and 3 spontaneous abortions. A higher pregnancy rate was observed in those without prior childbirth (82.4%) than in those who had prior childbirth (33.3%). In the EOC group, the median age was 34 (range, 22–42) years. Recurrence occurred in one patient. Menstrual regularity was maintained in 69.7% of the patients. Among the 14 married patients in this group, 12 achieved a total of 15 pregnancies (including 2 twin pregnancies), 16 live births, and 1 spontaneous abortion. The results of the study confirmed that FSS is a favorable surgical option for young women with early-stage BOTs or EOC who wish to preserve their fertility. However, additional investigations are needed to validate these findings.https://www.mdpi.com/2072-6694/15/22/5327fertility sparing surgeryepithelial ovarian cancerovarian cancerborderline ovarian tumorfertilitypregnancy |
| spellingShingle | Mu-En Ko Yi-Heng Lin Kuan-Ju Huang Wen-Chun Chang Bor-Ching Sheu Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study Cancers fertility sparing surgery epithelial ovarian cancer ovarian cancer borderline ovarian tumor fertility pregnancy |
| title | Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study |
| title_full | Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study |
| title_fullStr | Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study |
| title_full_unstemmed | Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study |
| title_short | Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study |
| title_sort | fertility and pregnancy outcomes after fertility sparing surgery for early stage borderline ovarian tumors and epithelial ovarian cancer a single center study |
| topic | fertility sparing surgery epithelial ovarian cancer ovarian cancer borderline ovarian tumor fertility pregnancy |
| url | https://www.mdpi.com/2072-6694/15/22/5327 |
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