Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial
Abstract Background Recent studies have demonstrated a correlation between intestinal flora and the severity of myocardial infarction as well as post-myocardial infarction repair. However, few studies have investigated whether probiotics reduce mortality and improve cardiovascular outcomes in patien...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Trials |
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| Online Access: | https://doi.org/10.1186/s13063-023-07443-5 |
| _version_ | 1827916726178676736 |
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| author | Yequn Chen Rongbing Chen Xin Wang Yan Zhou Liekai Hong Nianling Xiong Jinxiu Zhu Shu Ye Xuerui Tan |
| author_facet | Yequn Chen Rongbing Chen Xin Wang Yan Zhou Liekai Hong Nianling Xiong Jinxiu Zhu Shu Ye Xuerui Tan |
| author_sort | Yequn Chen |
| collection | DOAJ |
| description | Abstract Background Recent studies have demonstrated a correlation between intestinal flora and the severity of myocardial infarction as well as post-myocardial infarction repair. However, few studies have investigated whether probiotics reduce mortality and improve cardiovascular outcomes in patients with acute myocardial infarction. In this study, we will conduct a randomized controlled trial (RCT) to evaluate the effect of probiotics on in-hospital mortality and the incidence of major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI). Methods This is an open-label, randomized, controlled, superiority clinical trial involving 2594 adult patients who were diagnosed with acute myocardial infarction. Patients will be randomized to (1) receive bifidobacteria triple viable capsule (Bifidobacterium longum, Lactobacillus acidophilus, and Enterococcus faecalis) 840 mg, twice a day, plus standard treatment strategy during the hospital stay, for a maximum of 30 days, or (2) receive the standard treatment strategy and will not take the bifidobacterium triple live capsule. The primary outcome was in-hospital all-cause mortality. Discussion The purpose of this clinical trial is to determine whether probiotics can reduce in-hospital mortality and improve prognosis in patients with AMI, and the results will provide evidence for probiotics as a complementary treatment for AMI. Trial registration Chinese Clinical Trials Registry ChiCTR2000038797. Registered on 2 October 2020. |
| first_indexed | 2024-03-13T03:19:22Z |
| format | Article |
| id | doaj.art-a2252bace9fb42abbce13b96148bf70b |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-03-13T03:19:22Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-a2252bace9fb42abbce13b96148bf70b2023-06-25T11:26:51ZengBMCTrials1745-62152023-06-012411910.1186/s13063-023-07443-5Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trialYequn Chen0Rongbing Chen1Xin Wang2Yan Zhou3Liekai Hong4Nianling Xiong5Jinxiu Zhu6Shu Ye7Xuerui Tan8The First Affiliated Hospital of Shantou University Medical CollegeThe First Affiliated Hospital of Shantou University Medical CollegeThe First Affiliated Hospital of Shantou University Medical CollegeThe First Affiliated Hospital of Shantou University Medical CollegeThe First Affiliated Hospital of Shantou University Medical CollegeThe First Affiliated Hospital of Shantou University Medical CollegeThe First Affiliated Hospital of Shantou University Medical CollegeThe First Affiliated Hospital of Shantou University Medical CollegeThe First Affiliated Hospital of Shantou University Medical CollegeAbstract Background Recent studies have demonstrated a correlation between intestinal flora and the severity of myocardial infarction as well as post-myocardial infarction repair. However, few studies have investigated whether probiotics reduce mortality and improve cardiovascular outcomes in patients with acute myocardial infarction. In this study, we will conduct a randomized controlled trial (RCT) to evaluate the effect of probiotics on in-hospital mortality and the incidence of major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI). Methods This is an open-label, randomized, controlled, superiority clinical trial involving 2594 adult patients who were diagnosed with acute myocardial infarction. Patients will be randomized to (1) receive bifidobacteria triple viable capsule (Bifidobacterium longum, Lactobacillus acidophilus, and Enterococcus faecalis) 840 mg, twice a day, plus standard treatment strategy during the hospital stay, for a maximum of 30 days, or (2) receive the standard treatment strategy and will not take the bifidobacterium triple live capsule. The primary outcome was in-hospital all-cause mortality. Discussion The purpose of this clinical trial is to determine whether probiotics can reduce in-hospital mortality and improve prognosis in patients with AMI, and the results will provide evidence for probiotics as a complementary treatment for AMI. Trial registration Chinese Clinical Trials Registry ChiCTR2000038797. Registered on 2 October 2020.https://doi.org/10.1186/s13063-023-07443-5ProbioticsAcute myocardial infarctionMajor adverse cardiovascular events (MACE)MortalityRandomized controlled trial |
| spellingShingle | Yequn Chen Rongbing Chen Xin Wang Yan Zhou Liekai Hong Nianling Xiong Jinxiu Zhu Shu Ye Xuerui Tan Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial Trials Probiotics Acute myocardial infarction Major adverse cardiovascular events (MACE) Mortality Randomized controlled trial |
| title | Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial |
| title_full | Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial |
| title_fullStr | Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial |
| title_full_unstemmed | Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial |
| title_short | Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial |
| title_sort | effect of probiotic supplementation on in hospital mortality in patients with acute myocardial infarction a study protocol for an open label randomized controlled superiority clinical trial |
| topic | Probiotics Acute myocardial infarction Major adverse cardiovascular events (MACE) Mortality Randomized controlled trial |
| url | https://doi.org/10.1186/s13063-023-07443-5 |
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