Is Helicobacter Pylori Infection a Risk Factor for Idiopathic Thrombocytopenic Purpura in Children?
Background:Idiopathic thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder which occurs as a result of autoantibodies attachment to the platelets surface and subsequent destruction. Several organisms can mimic features of human antigens and induce autoantibody production. One of these o...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1748 |
| _version_ | 1818887114736009216 |
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| author | alireza abdollahi saeed shoar shadi ghasemi zohreh oloomi-yazdi |
| author_facet | alireza abdollahi saeed shoar shadi ghasemi zohreh oloomi-yazdi |
| author_sort | alireza abdollahi |
| collection | DOAJ |
| description | Background:Idiopathic thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder which occurs as a result of autoantibodies attachment to the platelets surface and subsequent destruction. Several organisms can mimic features of human antigens and induce autoantibody production. One of these organisms is Helicobacter pylori (HP).We purposed to assess the prevalence and relationship of H. pylori infection with ITP in a population of children.
Methods: One hundred six children younger than 18 years old were enrolled in this case-control study in which 42 children with ITP were in the case group and 64 healthy children were in the control group. Stool exam for detection of HP antigen were performed and the variables were compared between the 2 groups.
Results: Mean ± SD age of case and control group was 6.4±3.4 and 8.6±4.4 years old, respectively. H pylori stool antigen differ significantly between the case and the control groups (p<0.5).
Conclusion: Our results support the role of HP antigen in ITP of children. Given the endorsement of this relationship, recommended to be examined ITP-children patients for this infection. The exams are recommended to include UBT or Ag detection in stool and not measuring the level of Abs of HP in the blood because false positive and negative cases are high in the latter. Moreover, it would be difficult to differentiate an active/new infection from an infection that has happened in the past. |
| first_indexed | 2024-12-19T16:32:05Z |
| format | Article |
| id | doaj.art-a22535c7dd5a4773a84345b3c42f5137 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-12-19T16:32:05Z |
| publishDate | 2014-08-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-a22535c7dd5a4773a84345b3c42f51372022-12-21T20:14:10ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062014-08-011Is Helicobacter Pylori Infection a Risk Factor for Idiopathic Thrombocytopenic Purpura in Children?alireza abdollahi0saeed shoar1shadi ghasemi2zohreh oloomi-yazdi3tehran university of medical sciencesDepartment of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, IranDepartment of Pediatrics, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, IranBackground:Idiopathic thrombocytopenic purpura (ITP) is an autoimmune bleeding disorder which occurs as a result of autoantibodies attachment to the platelets surface and subsequent destruction. Several organisms can mimic features of human antigens and induce autoantibody production. One of these organisms is Helicobacter pylori (HP).We purposed to assess the prevalence and relationship of H. pylori infection with ITP in a population of children. Methods: One hundred six children younger than 18 years old were enrolled in this case-control study in which 42 children with ITP were in the case group and 64 healthy children were in the control group. Stool exam for detection of HP antigen were performed and the variables were compared between the 2 groups. Results: Mean ± SD age of case and control group was 6.4±3.4 and 8.6±4.4 years old, respectively. H pylori stool antigen differ significantly between the case and the control groups (p<0.5). Conclusion: Our results support the role of HP antigen in ITP of children. Given the endorsement of this relationship, recommended to be examined ITP-children patients for this infection. The exams are recommended to include UBT or Ag detection in stool and not measuring the level of Abs of HP in the blood because false positive and negative cases are high in the latter. Moreover, it would be difficult to differentiate an active/new infection from an infection that has happened in the past.https://mjhid.org/index.php/mjhid/article/view/1748Idiopathic Thrombocytopenic PurpuraH pyloriChildren |
| spellingShingle | alireza abdollahi saeed shoar shadi ghasemi zohreh oloomi-yazdi Is Helicobacter Pylori Infection a Risk Factor for Idiopathic Thrombocytopenic Purpura in Children? Mediterranean Journal of Hematology and Infectious Diseases Idiopathic Thrombocytopenic Purpura H pylori Children |
| title | Is Helicobacter Pylori Infection a Risk Factor for Idiopathic Thrombocytopenic Purpura in Children? |
| title_full | Is Helicobacter Pylori Infection a Risk Factor for Idiopathic Thrombocytopenic Purpura in Children? |
| title_fullStr | Is Helicobacter Pylori Infection a Risk Factor for Idiopathic Thrombocytopenic Purpura in Children? |
| title_full_unstemmed | Is Helicobacter Pylori Infection a Risk Factor for Idiopathic Thrombocytopenic Purpura in Children? |
| title_short | Is Helicobacter Pylori Infection a Risk Factor for Idiopathic Thrombocytopenic Purpura in Children? |
| title_sort | is helicobacter pylori infection a risk factor for idiopathic thrombocytopenic purpura in children |
| topic | Idiopathic Thrombocytopenic Purpura H pylori Children |
| url | https://mjhid.org/index.php/mjhid/article/view/1748 |
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