Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage
Intracerebral hemorrhage (ICH) is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic st...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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Series: | Neural Regeneration Research |
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Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=4;spage=558;epage=561;aulast=Pías-Peleteiro |
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author | Juan Pías-Peleteiro Francisco Campos José Castillo Tomás Sobrino |
author_facet | Juan Pías-Peleteiro Francisco Campos José Castillo Tomás Sobrino |
author_sort | Juan Pías-Peleteiro |
collection | DOAJ |
description | Intracerebral hemorrhage (ICH) is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic strategies able to promote brain repair processes. Therapeutic angiogenesis and vasculogenesis hold promise to improve outcome of ICH patients. In this regard, circulating endothelial progenitor cells (EPCs) have recently been suggested to be a marker of vascular risk and endothelial function. Moreover, EPC levels have been associated with good neurological and functional outcome as well as reduced residual hematoma volume in ICH patients. Finally, experimental and clinical studies indicate that EPC might mediate endothelial cell regeneration and neovascularization. Therefore, EPC-based therapy could be an excellent therapeutic option in ICH. In this mini-review, we discuss the present status of knowledge about the possible therapeutic role of EPCs in ICH, molecular mechanisms, and the future perspectives and strategies for their use in clinical practice. |
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format | Article |
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institution | Directory Open Access Journal |
issn | 1673-5374 |
language | English |
last_indexed | 2024-12-11T01:29:59Z |
publishDate | 2017-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Neural Regeneration Research |
spelling | doaj.art-a22632561e7b4bb9978255db24b38e412022-12-22T01:25:23ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-0112455856110.4103/1673-5374.205085Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhageJuan Pías-PeleteiroFrancisco CamposJosé CastilloTomás SobrinoIntracerebral hemorrhage (ICH) is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic strategies able to promote brain repair processes. Therapeutic angiogenesis and vasculogenesis hold promise to improve outcome of ICH patients. In this regard, circulating endothelial progenitor cells (EPCs) have recently been suggested to be a marker of vascular risk and endothelial function. Moreover, EPC levels have been associated with good neurological and functional outcome as well as reduced residual hematoma volume in ICH patients. Finally, experimental and clinical studies indicate that EPC might mediate endothelial cell regeneration and neovascularization. Therefore, EPC-based therapy could be an excellent therapeutic option in ICH. In this mini-review, we discuss the present status of knowledge about the possible therapeutic role of EPCs in ICH, molecular mechanisms, and the future perspectives and strategies for their use in clinical practice.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=4;spage=558;epage=561;aulast=Pías-Peleteirocellular therapy; endothelial progenitor cells; growth factors; intracerebral hemorrhage; neurorepair; outcome |
spellingShingle | Juan Pías-Peleteiro Francisco Campos José Castillo Tomás Sobrino Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage Neural Regeneration Research cellular therapy; endothelial progenitor cells; growth factors; intracerebral hemorrhage; neurorepair; outcome |
title | Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage |
title_full | Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage |
title_fullStr | Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage |
title_full_unstemmed | Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage |
title_short | Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage |
title_sort | endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage |
topic | cellular therapy; endothelial progenitor cells; growth factors; intracerebral hemorrhage; neurorepair; outcome |
url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=4;spage=558;epage=561;aulast=Pías-Peleteiro |
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