Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage

Intracerebral hemorrhage (ICH) is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic st...

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Main Authors: Juan Pías-Peleteiro, Francisco Campos, José Castillo, Tomás Sobrino
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=4;spage=558;epage=561;aulast=Pías-Peleteiro
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author Juan Pías-Peleteiro
Francisco Campos
José Castillo
Tomás Sobrino
author_facet Juan Pías-Peleteiro
Francisco Campos
José Castillo
Tomás Sobrino
author_sort Juan Pías-Peleteiro
collection DOAJ
description Intracerebral hemorrhage (ICH) is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic strategies able to promote brain repair processes. Therapeutic angiogenesis and vasculogenesis hold promise to improve outcome of ICH patients. In this regard, circulating endothelial progenitor cells (EPCs) have recently been suggested to be a marker of vascular risk and endothelial function. Moreover, EPC levels have been associated with good neurological and functional outcome as well as reduced residual hematoma volume in ICH patients. Finally, experimental and clinical studies indicate that EPC might mediate endothelial cell regeneration and neovascularization. Therefore, EPC-based therapy could be an excellent therapeutic option in ICH. In this mini-review, we discuss the present status of knowledge about the possible therapeutic role of EPCs in ICH, molecular mechanisms, and the future perspectives and strategies for their use in clinical practice.
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spelling doaj.art-a22632561e7b4bb9978255db24b38e412022-12-22T01:25:23ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742017-01-0112455856110.4103/1673-5374.205085Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhageJuan Pías-PeleteiroFrancisco CamposJosé CastilloTomás SobrinoIntracerebral hemorrhage (ICH) is the most severe cerebrovascular disease, which represents a leading cause of death and disability in developed countries. However, therapeutic options are limited, so is mandatory to investigate repairing processes after stroke in order to develop new therapeutic strategies able to promote brain repair processes. Therapeutic angiogenesis and vasculogenesis hold promise to improve outcome of ICH patients. In this regard, circulating endothelial progenitor cells (EPCs) have recently been suggested to be a marker of vascular risk and endothelial function. Moreover, EPC levels have been associated with good neurological and functional outcome as well as reduced residual hematoma volume in ICH patients. Finally, experimental and clinical studies indicate that EPC might mediate endothelial cell regeneration and neovascularization. Therefore, EPC-based therapy could be an excellent therapeutic option in ICH. In this mini-review, we discuss the present status of knowledge about the possible therapeutic role of EPCs in ICH, molecular mechanisms, and the future perspectives and strategies for their use in clinical practice.http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=4;spage=558;epage=561;aulast=Pías-Peleteirocellular therapy; endothelial progenitor cells; growth factors; intracerebral hemorrhage; neurorepair; outcome
spellingShingle Juan Pías-Peleteiro
Francisco Campos
José Castillo
Tomás Sobrino
Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage
Neural Regeneration Research
cellular therapy; endothelial progenitor cells; growth factors; intracerebral hemorrhage; neurorepair; outcome
title Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage
title_full Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage
title_fullStr Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage
title_full_unstemmed Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage
title_short Endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage
title_sort endothelial progenitor cells as a therapeutic option in intracerebral hemorrhage
topic cellular therapy; endothelial progenitor cells; growth factors; intracerebral hemorrhage; neurorepair; outcome
url http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=4;spage=558;epage=561;aulast=Pías-Peleteiro
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AT tomassobrino endothelialprogenitorcellsasatherapeuticoptioninintracerebralhemorrhage