The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins

ABSTRACT Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear. The 20-kDa ISG ISG20 is a nuclear 3′–5′ exonuclea...

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Bibliographic Details
Main Authors: Christopher M. Weiss, Derek W. Trobaugh, Chengqun Sun, Tiffany M. Lucas, Michael S. Diamond, Kate D. Ryman, William B. Klimstra
Format: Article
Language:English
Published: American Society for Microbiology 2018-10-01
Series:mSphere
Subjects:
alphavirus
host-pathogen interactions
innate immunity
interferon-stimulated gene
virus-host interactions
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00209-18

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