Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial
IntroductionBy 2050, the worldwide percentage of people 65 years and older is assumed to have doubled compared to current numbers. Therefore, finding ways of promoting healthy (cognitive) aging is crucial. Physical activity is considered an effective approach to counteract not only physical but also...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1254194/full |
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| author | Simon J. Schrenk Stefan Brodoehl Stefano Flor Christiane Frahm Christian Gaser Christian Gaser Rami Abou Hamdan Marco Herbsleb Marco Herbsleb Christoph Kaleta Fabian Kattlun Fabian Kattlun Hans-Josef Müller Christian Puta Christian Puta Christian Puta Monique Radscheidt Adriana L. Ruiz-Rizzo Tannaz Saraei André Scherag André Scherag André Scherag Thomas Steidten Otto W. Witte Kathrin Finke Kathrin Finke |
| author_facet | Simon J. Schrenk Stefan Brodoehl Stefano Flor Christiane Frahm Christian Gaser Christian Gaser Rami Abou Hamdan Marco Herbsleb Marco Herbsleb Christoph Kaleta Fabian Kattlun Fabian Kattlun Hans-Josef Müller Christian Puta Christian Puta Christian Puta Monique Radscheidt Adriana L. Ruiz-Rizzo Tannaz Saraei André Scherag André Scherag André Scherag Thomas Steidten Otto W. Witte Kathrin Finke Kathrin Finke |
| author_sort | Simon J. Schrenk |
| collection | DOAJ |
| description | IntroductionBy 2050, the worldwide percentage of people 65 years and older is assumed to have doubled compared to current numbers. Therefore, finding ways of promoting healthy (cognitive) aging is crucial. Physical activity is considered an effective approach to counteract not only physical but also cognitive decline. However, the underlying mechanisms that drive the benefits of regular physical activity on cognitive function are not fully understood. This randomized controlled trial aims to analyze the effect of an eight-week standardized physical activity training program in older humans on cognitive, brain, and gut-barrier function as well as the relationship between the resulting changes.Methods and analysisOne-hundred healthy participants aged 60 to 75 years will be recruited. First, participants will undergo an extensive baseline assessment consisting of neurocognitive tests, functional and structural brain imaging, physical fitness tests, and gut-microbiome profiling. Next, participants will be randomized into either a multi-component physical activity group (experimental condition) or a relaxation group (active control condition), with each training lasting 8 weeks and including an equal number and duration of exercises. The whole intervention will be online-based, i.e., participants will find their intervention schedule and all materials needed on the study website. After the intervention phase, participants will have their post-intervention assessment, which consists of the same measures and tests as the baseline assessment. The primary outcome of this study is the change in the cognitive parameter of visual processing speed from baseline to post-measurement, which will on average take place 10 weeks after the randomization. Secondary outcomes related to cognitive, brain, and microbiome data will be analyzed exploratory.Clinical trial registration:https://drks.de/search/de/trial/DRKS00028022 |
| first_indexed | 2024-03-12T00:43:22Z |
| format | Article |
| id | doaj.art-a2289b8f695e44d699a90768e08f4a98 |
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| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-12T00:43:22Z |
| publishDate | 2023-09-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-a2289b8f695e44d699a90768e08f4a982023-09-15T01:25:59ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-09-011510.3389/fnagi.2023.12541941254194Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trialSimon J. Schrenk0Stefan Brodoehl1Stefano Flor2Christiane Frahm3Christian Gaser4Christian Gaser5Rami Abou Hamdan6Marco Herbsleb7Marco Herbsleb8Christoph Kaleta9Fabian Kattlun10Fabian Kattlun11Hans-Josef Müller12Christian Puta13Christian Puta14Christian Puta15Monique Radscheidt16Adriana L. Ruiz-Rizzo17Tannaz Saraei18André Scherag19André Scherag20André Scherag21Thomas Steidten22Otto W. Witte23Kathrin Finke24Kathrin Finke25Department of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyDepartment of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyInstitute of Experimental Medicine, Christian-Albrechts-University zu Kiel, Kiel, GermanyDepartment of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyDepartment of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyDepartment of Psychiatry and Psychotherapy, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyDepartment of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, GermanyDepartment of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, GermanyDepartment of Psychosomatic Medicine and Psychotherapy, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyInstitute of Experimental Medicine, Christian-Albrechts-University zu Kiel, Kiel, GermanyDepartment of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyCenter for Sepsis Control and Care (CSCC), Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyDepartment of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, GermanyDepartment of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, GermanyCenter for Sepsis Control and Care (CSCC), Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyCenter for Interdisciplinary Prevention of Diseases Related to Professional Activities, Friedrich-Schiller-University Jena, Jena, GermanyDepartment of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyDepartment of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyDepartment of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyCenter for Sepsis Control and Care (CSCC), Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyCenter for Clinical Studies, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyInstitute of Medical Statistics, Computer and Data Sciences, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyDepartment of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, GermanyDepartment of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyDepartment of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyCenter for Sepsis Control and Care (CSCC), Jena University Hospital – Friedrich Schiller University of Jena, Jena, GermanyIntroductionBy 2050, the worldwide percentage of people 65 years and older is assumed to have doubled compared to current numbers. Therefore, finding ways of promoting healthy (cognitive) aging is crucial. Physical activity is considered an effective approach to counteract not only physical but also cognitive decline. However, the underlying mechanisms that drive the benefits of regular physical activity on cognitive function are not fully understood. This randomized controlled trial aims to analyze the effect of an eight-week standardized physical activity training program in older humans on cognitive, brain, and gut-barrier function as well as the relationship between the resulting changes.Methods and analysisOne-hundred healthy participants aged 60 to 75 years will be recruited. First, participants will undergo an extensive baseline assessment consisting of neurocognitive tests, functional and structural brain imaging, physical fitness tests, and gut-microbiome profiling. Next, participants will be randomized into either a multi-component physical activity group (experimental condition) or a relaxation group (active control condition), with each training lasting 8 weeks and including an equal number and duration of exercises. The whole intervention will be online-based, i.e., participants will find their intervention schedule and all materials needed on the study website. After the intervention phase, participants will have their post-intervention assessment, which consists of the same measures and tests as the baseline assessment. The primary outcome of this study is the change in the cognitive parameter of visual processing speed from baseline to post-measurement, which will on average take place 10 weeks after the randomization. Secondary outcomes related to cognitive, brain, and microbiome data will be analyzed exploratory.Clinical trial registration:https://drks.de/search/de/trial/DRKS00028022https://www.frontiersin.org/articles/10.3389/fnagi.2023.1254194/fullcognitionphysical activityonline interventionfMRIhealthyolder adults |
| spellingShingle | Simon J. Schrenk Stefan Brodoehl Stefano Flor Christiane Frahm Christian Gaser Christian Gaser Rami Abou Hamdan Marco Herbsleb Marco Herbsleb Christoph Kaleta Fabian Kattlun Fabian Kattlun Hans-Josef Müller Christian Puta Christian Puta Christian Puta Monique Radscheidt Adriana L. Ruiz-Rizzo Tannaz Saraei André Scherag André Scherag André Scherag Thomas Steidten Otto W. Witte Kathrin Finke Kathrin Finke Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial Frontiers in Aging Neuroscience cognition physical activity online intervention fMRI healthy older adults |
| title | Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial |
| title_full | Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial |
| title_fullStr | Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial |
| title_full_unstemmed | Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial |
| title_short | Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial |
| title_sort | impact of an online guided physical activity training on cognition and gut brain axis interactions in older adults protocol of a randomized controlled trial |
| topic | cognition physical activity online intervention fMRI healthy older adults |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1254194/full |
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