Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart
Abstract Circadian rhythms play a crucial role in the regulation of various physiological processes, including cardiovascular function and metabolism. Exercise provokes numerous beneficial adaptations in heart, including physiological hypertrophy, and serves to shift circadian rhythms. This study in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-50113-4 |
| _version_ | 1797363387597848576 |
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| author | Michael B. Dial Elias M. Malek Greco A. Neblina Austin R. Cooper Nikoleta I. Vaslieva Rebecca Frommer Magdy Girgis Buddhadeb Dawn Graham R. McGinnis |
| author_facet | Michael B. Dial Elias M. Malek Greco A. Neblina Austin R. Cooper Nikoleta I. Vaslieva Rebecca Frommer Magdy Girgis Buddhadeb Dawn Graham R. McGinnis |
| author_sort | Michael B. Dial |
| collection | DOAJ |
| description | Abstract Circadian rhythms play a crucial role in the regulation of various physiological processes, including cardiovascular function and metabolism. Exercise provokes numerous beneficial adaptations in heart, including physiological hypertrophy, and serves to shift circadian rhythms. This study investigated the impact of time-restricted exercise training on exercise-induced adaptations in the heart and locomotor activity rhythms. Male mice (n = 45) were allocated to perform voluntary, time-restricted exercise in the early active phase (EAP), late active phase (LAP), or remain sedentary (SED) for 6 weeks. Subsequently, mice were allowed 24-h ad libitum access to the running wheel to assess diurnal rhythms in locomotor activity. Heart weight and cross-sectional area were measured at sacrifice, and cardiac protein and gene expression levels were assessed for markers of mitochondrial abundance and circadian clock gene expression. Mice rapidly adapted to wheel running, with EAP mice exhibiting a significantly greater running distance compared to LAP mice. Time-restricted exercise induced a shift in voluntary wheel activity during the 24-h free access period, with the acrophase in activity being significantly earlier in EAP mice compared to LAP mice. Gene expression analysis revealed a higher expression of Per1 in LAP mice. EAP exercise elicited greater cardiac hypertrophy compared to LAP exercise. These findings suggest that the timing of exercise affects myocardial adaptations, with exercise in the early active phase inducing hypertrophy in the heart. Understanding the time-of-day dependent response to exercise in the heart may have implications for optimizing exercise interventions for cardiovascular health. |
| first_indexed | 2024-03-08T16:20:39Z |
| format | Article |
| id | doaj.art-a22da51410804c8e9141956f35a40584 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T16:20:39Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a22da51410804c8e9141956f35a405842024-01-07T12:24:10ZengNature PortfolioScientific Reports2045-23222024-01-0114111010.1038/s41598-023-50113-4Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heartMichael B. Dial0Elias M. Malek1Greco A. Neblina2Austin R. Cooper3Nikoleta I. Vaslieva4Rebecca Frommer5Magdy Girgis6Buddhadeb Dawn7Graham R. McGinnis8Department of Kinesiology and Nutrition Sciences, University of Nevada, Las VegasDepartment of Kinesiology and Nutrition Sciences, University of Nevada, Las VegasDepartment of Kinesiology and Nutrition Sciences, University of Nevada, Las VegasDepartment of Kinesiology and Nutrition Sciences, University of Nevada, Las VegasDepartment of Kinesiology and Nutrition Sciences, University of Nevada, Las VegasDepartment of Internal Medicine, Kirk Kerkorian School of Medicine, University of Nevada, Las VegasDepartment of Internal Medicine, Kirk Kerkorian School of Medicine, University of Nevada, Las VegasDepartment of Internal Medicine, Kirk Kerkorian School of Medicine, University of Nevada, Las VegasDepartment of Kinesiology and Nutrition Sciences, University of Nevada, Las VegasAbstract Circadian rhythms play a crucial role in the regulation of various physiological processes, including cardiovascular function and metabolism. Exercise provokes numerous beneficial adaptations in heart, including physiological hypertrophy, and serves to shift circadian rhythms. This study investigated the impact of time-restricted exercise training on exercise-induced adaptations in the heart and locomotor activity rhythms. Male mice (n = 45) were allocated to perform voluntary, time-restricted exercise in the early active phase (EAP), late active phase (LAP), or remain sedentary (SED) for 6 weeks. Subsequently, mice were allowed 24-h ad libitum access to the running wheel to assess diurnal rhythms in locomotor activity. Heart weight and cross-sectional area were measured at sacrifice, and cardiac protein and gene expression levels were assessed for markers of mitochondrial abundance and circadian clock gene expression. Mice rapidly adapted to wheel running, with EAP mice exhibiting a significantly greater running distance compared to LAP mice. Time-restricted exercise induced a shift in voluntary wheel activity during the 24-h free access period, with the acrophase in activity being significantly earlier in EAP mice compared to LAP mice. Gene expression analysis revealed a higher expression of Per1 in LAP mice. EAP exercise elicited greater cardiac hypertrophy compared to LAP exercise. These findings suggest that the timing of exercise affects myocardial adaptations, with exercise in the early active phase inducing hypertrophy in the heart. Understanding the time-of-day dependent response to exercise in the heart may have implications for optimizing exercise interventions for cardiovascular health.https://doi.org/10.1038/s41598-023-50113-4 |
| spellingShingle | Michael B. Dial Elias M. Malek Greco A. Neblina Austin R. Cooper Nikoleta I. Vaslieva Rebecca Frommer Magdy Girgis Buddhadeb Dawn Graham R. McGinnis Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart Scientific Reports |
| title | Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart |
| title_full | Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart |
| title_fullStr | Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart |
| title_full_unstemmed | Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart |
| title_short | Effects of time-restricted exercise on activity rhythms and exercise-induced adaptations in the heart |
| title_sort | effects of time restricted exercise on activity rhythms and exercise induced adaptations in the heart |
| url | https://doi.org/10.1038/s41598-023-50113-4 |
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