Clinical study on corneal collagen cross-linking combined with RGPCL in treatment of keratoconus
AIM: To observe the safety and efficacy of epithelium-off corneal collagen cross-linking(CXL)combined with rigid gas permeable contact lens(RGPCL)in treatment of progressive keratoconus.<p>METHODS: From January 2015 to January 2017, 51 cases(51 eyes)of patients diagnosed with keratoconus and e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2019-06-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2019/6/201906032.pdf |
| _version_ | 1818893323674320896 |
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| author | Ying-Nan Xu Qin Jiang Jin-Song Xue |
| author_facet | Ying-Nan Xu Qin Jiang Jin-Song Xue |
| author_sort | Ying-Nan Xu |
| collection | DOAJ |
| description | AIM: To observe the safety and efficacy of epithelium-off corneal collagen cross-linking(CXL)combined with rigid gas permeable contact lens(RGPCL)in treatment of progressive keratoconus.<p>METHODS: From January 2015 to January 2017, 51 cases(51 eyes)of patients diagnosed with keratoconus and epithelium-off CXL treatment at the Eye Hospital of Nanjing Medical University were collected. The patients were divided into two groups according to whether they wore RGPCL or not after treatment. Group A: 30 eyes, epithelium-off CXL was removed and wear a framed mirror after treatment; Group B: 21 eyes, epithelium-off CXL was removed and RGPCL was worn after the condition was stable. Observed the best corrected visual acuity(BCVA), spherical equivalent(SE), minimum keratometry of the anterior corneal surface(K1), maximum keratometry of the anterior corneal surface(K2), mean keratometry(Km), maximal keratometry(Kmax), corneal vertex thickness, thinnest corneal thickness(TCT)before and 12mo after treatment.<p>RESULTS: No statistically significant differences were found before the therapy between the two groups in BCVA, SE, K1, K2, Km, Kmax, corneal vertex thickness, and TCT between the two groups(<i>P</i>>0.05). 12mo after treatment, BCVA in group B was significantly higher than that in group A(0.11±0.03 <i>vs</i> 0.26±0.16), the corneal vertex thickness of group B was lower than that of group A(431.8±14.41μm <i>vs</i> 461.38±32.68μm)(<i>P</i><0.05), there was no significant difference in other parameters between the two groups.<p>CONCLUSION: Epithelium-off CXL can effectively delay or control the progression of keratoconus. Wearing RGPCL after treatment can effectively improve BCVA. |
| first_indexed | 2024-12-19T18:10:47Z |
| format | Article |
| id | doaj.art-a22e2d4d7d5a4efa9e16b5d7d62b1148 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-19T18:10:47Z |
| publishDate | 2019-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-a22e2d4d7d5a4efa9e16b5d7d62b11482022-12-21T20:11:19ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232019-06-011961035103810.3980/j.issn.1672-5123.2019.6.32Clinical study on corneal collagen cross-linking combined with RGPCL in treatment of keratoconusYing-Nan Xu0Qin Jiang1Jin-Song Xue2The Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210005, Jiangsu Province, ChinaThe Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210005, Jiangsu Province, ChinaThe Affiliated Eye Hospital of Nanjing Medical University, Nanjing 210005, Jiangsu Province, ChinaAIM: To observe the safety and efficacy of epithelium-off corneal collagen cross-linking(CXL)combined with rigid gas permeable contact lens(RGPCL)in treatment of progressive keratoconus.<p>METHODS: From January 2015 to January 2017, 51 cases(51 eyes)of patients diagnosed with keratoconus and epithelium-off CXL treatment at the Eye Hospital of Nanjing Medical University were collected. The patients were divided into two groups according to whether they wore RGPCL or not after treatment. Group A: 30 eyes, epithelium-off CXL was removed and wear a framed mirror after treatment; Group B: 21 eyes, epithelium-off CXL was removed and RGPCL was worn after the condition was stable. Observed the best corrected visual acuity(BCVA), spherical equivalent(SE), minimum keratometry of the anterior corneal surface(K1), maximum keratometry of the anterior corneal surface(K2), mean keratometry(Km), maximal keratometry(Kmax), corneal vertex thickness, thinnest corneal thickness(TCT)before and 12mo after treatment.<p>RESULTS: No statistically significant differences were found before the therapy between the two groups in BCVA, SE, K1, K2, Km, Kmax, corneal vertex thickness, and TCT between the two groups(<i>P</i>>0.05). 12mo after treatment, BCVA in group B was significantly higher than that in group A(0.11±0.03 <i>vs</i> 0.26±0.16), the corneal vertex thickness of group B was lower than that of group A(431.8±14.41μm <i>vs</i> 461.38±32.68μm)(<i>P</i><0.05), there was no significant difference in other parameters between the two groups.<p>CONCLUSION: Epithelium-off CXL can effectively delay or control the progression of keratoconus. Wearing RGPCL after treatment can effectively improve BCVA.http://ies.ijo.cn/cn_publish/2019/6/201906032.pdfcorneal collagen cross-linkingkeratoconusrigid gas permeable contact lens |
| spellingShingle | Ying-Nan Xu Qin Jiang Jin-Song Xue Clinical study on corneal collagen cross-linking combined with RGPCL in treatment of keratoconus Guoji Yanke Zazhi corneal collagen cross-linking keratoconus rigid gas permeable contact lens |
| title | Clinical study on corneal collagen cross-linking combined with RGPCL in treatment of keratoconus |
| title_full | Clinical study on corneal collagen cross-linking combined with RGPCL in treatment of keratoconus |
| title_fullStr | Clinical study on corneal collagen cross-linking combined with RGPCL in treatment of keratoconus |
| title_full_unstemmed | Clinical study on corneal collagen cross-linking combined with RGPCL in treatment of keratoconus |
| title_short | Clinical study on corneal collagen cross-linking combined with RGPCL in treatment of keratoconus |
| title_sort | clinical study on corneal collagen cross linking combined with rgpcl in treatment of keratoconus |
| topic | corneal collagen cross-linking keratoconus rigid gas permeable contact lens |
| url | http://ies.ijo.cn/cn_publish/2019/6/201906032.pdf |
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