Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women
Abstract The incidence of breast cancer has increased dramatically in China. We evaluated the clinical and epidemiologic factors associated with breast cancer, and its stage in a case‐control study of Northeast Chinese women. We also examined whether these factors were differentially distributed amo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-12-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2589 |
| _version_ | 1818202683789541376 |
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| author | Dong‐Man Ye Qiang Li Tao Yu Hao‐Tian Wang Ya‐Hong Luo Wen‐Qing Li |
| author_facet | Dong‐Man Ye Qiang Li Tao Yu Hao‐Tian Wang Ya‐Hong Luo Wen‐Qing Li |
| author_sort | Dong‐Man Ye |
| collection | DOAJ |
| description | Abstract The incidence of breast cancer has increased dramatically in China. We evaluated the clinical and epidemiologic factors associated with breast cancer, and its stage in a case‐control study of Northeast Chinese women. We also examined whether these factors were differentially distributed among molecular subtypes of breast cancer in a case‐only analysis. We identified 1118 breast cancer patients and 2284 healthy women from Cancer Hospital of Medical University between January 2014 and December 2017. Logistic regression models were used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). We found that postmenopausal women had a decreased risk of breast cancer (multivariate‐adjusted OR = 0.33, 95% CI:0.25‐0.43), and tended to have breast cancer of human epidermal growth factor receptor 2 (HER2)‐overexpressing (multivariate‐adjusted OR = 2.99, 95% CI: 1.49‐5.97) and triple‐negative (multivariate‐adjusted OR = 2.16, 95% CI: 1.02‐4.56) subtypes, compared with the luminal B subtype. Women with history of abortion had an increased risk of breast cancer (multivariate‐adjusted OR = 4.70, 95% CI: 3.60‐6.14). Women with high breast density and high Breast Imaging Reporting and Data System (BIRADS) scores of lesions tended to have breast cancer of advanced stage, but were not differentially distributed among its molecular subtypes. In conclusion, postmenopausal women had decreased risk of breast cancer, and tended to have nonluminal subtype, while women with history of abortion had increased risk of breast cancer. Women with high breast density and BIRADS scores of lesions tended to have advanced stage breast cancer. We provide evidence on the epidemiologic factors for breast cancer and its subtypes, which may help with breast cancer risk stratification. |
| first_indexed | 2024-12-12T03:13:21Z |
| format | Article |
| id | doaj.art-a230eb5ad2a44b0d9f14718bef9c43e9 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-12T03:13:21Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-a230eb5ad2a44b0d9f14718bef9c43e92022-12-22T00:40:21ZengWileyCancer Medicine2045-76342019-12-018177431744510.1002/cam4.2589Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese womenDong‐Man Ye0Qiang Li1Tao Yu2Hao‐Tian Wang3Ya‐Hong Luo4Wen‐Qing Li5Department of Medical Imaging Liaoning Cancer Hospital & Institute Cancer Hospital of China Medical University Shenyang P. R. ChinaDepartment of pathology Liaoning Cancer Hospital & Institute Cancer Hospital of China Medical University Shenyang P. R. ChinaDepartment of Medical Imaging Liaoning Cancer Hospital & Institute Cancer Hospital of China Medical University Shenyang P. R. ChinaThe First Clinical College Dalian Medical University Dalian P. R. ChinaDepartment of Medical Imaging Liaoning Cancer Hospital & Institute Cancer Hospital of China Medical University Shenyang P. R. ChinaKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Cancer Epidemiology Peking University Cancer Hospital & Institute Beijing P. R. ChinaAbstract The incidence of breast cancer has increased dramatically in China. We evaluated the clinical and epidemiologic factors associated with breast cancer, and its stage in a case‐control study of Northeast Chinese women. We also examined whether these factors were differentially distributed among molecular subtypes of breast cancer in a case‐only analysis. We identified 1118 breast cancer patients and 2284 healthy women from Cancer Hospital of Medical University between January 2014 and December 2017. Logistic regression models were used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). We found that postmenopausal women had a decreased risk of breast cancer (multivariate‐adjusted OR = 0.33, 95% CI:0.25‐0.43), and tended to have breast cancer of human epidermal growth factor receptor 2 (HER2)‐overexpressing (multivariate‐adjusted OR = 2.99, 95% CI: 1.49‐5.97) and triple‐negative (multivariate‐adjusted OR = 2.16, 95% CI: 1.02‐4.56) subtypes, compared with the luminal B subtype. Women with history of abortion had an increased risk of breast cancer (multivariate‐adjusted OR = 4.70, 95% CI: 3.60‐6.14). Women with high breast density and high Breast Imaging Reporting and Data System (BIRADS) scores of lesions tended to have breast cancer of advanced stage, but were not differentially distributed among its molecular subtypes. In conclusion, postmenopausal women had decreased risk of breast cancer, and tended to have nonluminal subtype, while women with history of abortion had increased risk of breast cancer. Women with high breast density and BIRADS scores of lesions tended to have advanced stage breast cancer. We provide evidence on the epidemiologic factors for breast cancer and its subtypes, which may help with breast cancer risk stratification.https://doi.org/10.1002/cam4.2589advanced stagebreast cancerearly stagemolecular subtypes |
| spellingShingle | Dong‐Man Ye Qiang Li Tao Yu Hao‐Tian Wang Ya‐Hong Luo Wen‐Qing Li Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women Cancer Medicine advanced stage breast cancer early stage molecular subtypes |
| title | Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women |
| title_full | Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women |
| title_fullStr | Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women |
| title_full_unstemmed | Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women |
| title_short | Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women |
| title_sort | clinical and epidemiologic factors associated with breast cancer and its subtypes among northeast chinese women |
| topic | advanced stage breast cancer early stage molecular subtypes |
| url | https://doi.org/10.1002/cam4.2589 |
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