TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity

TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity

IL-2 is a pleiotropic cytokine that plays an essential role in the survival, expansion, and function of CD8 T cells, regulatory T cells (Tregs), and natural killer (NK) cells. Previous studies showed that binding IL-2 with an anti-IL-2 monoclonal antibody (mAb) with a particular specificity could bl...

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Bibliographic Details
Main Authors: Jun-Young Lee, Eunjin Lee, Sung-Wook Hong, Daeun Kim, O. Eunju, Jonathan Sprent, Sin-Hyeog Im, You Jeong Lee, Charles D. Surh
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
il-2
tcb2
cytokine-antibody complex
immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1681869

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