Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study
Abstract Several observational studies have investigated the association between cannabis use and intraocular pressure, but its association with primary open-angle glaucoma (POAG) remains unclear. In this study, we leveraged human genetic data to assess through Mendelian randomization (MR) whether c...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-45872-z |
| _version_ | 1797630182573473792 |
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| author | Andreas Katsimpris Sebastian-Edgar Baumeister Hansjörg Baurecht Andrew J. Tatham Michael Nolde |
| author_facet | Andreas Katsimpris Sebastian-Edgar Baumeister Hansjörg Baurecht Andrew J. Tatham Michael Nolde |
| author_sort | Andreas Katsimpris |
| collection | DOAJ |
| description | Abstract Several observational studies have investigated the association between cannabis use and intraocular pressure, but its association with primary open-angle glaucoma (POAG) remains unclear. In this study, we leveraged human genetic data to assess through Mendelian randomization (MR) whether cannabis use affects POAG. We used five single-nucleotide polymorphisms (SNPs) associated with lifetime cannabis use (P-value < 5 × 10–8) from a genome-wide association study (GWAS) (N = 184,765) by the International Cannabis Consortium, 23andMe, and UK Biobank and eleven SNPs associated with cannabis use disorder (P-value < 5 × 10–7) from a GWAS meta-analysis of (17,068 cases and 357,219 controls of European descent) from Psychiatric Genomics Consortium Substance Use Disorders working group, Lundbeck Foundation Initiative for Integrative Psychiatric Research, and deCode. We associated the selected five SNPs from the GWAS of lifetime cannabis use and the eleven SNPs from the GWAS of cannabis use disorder, with the largest to date GWAS meta-analysis of POAG (16,677 cases and 199,580 controls). MR analysis suggested no evidence for a causal association of lifetime cannabis use and cannabis use disorder with POAG (odds ratio (OR) of outcome per doubling of the odds of exposure (95% confidence interval): 1.04 (0.88; 1.23) for lifetime cannabis use and 0.97 (0.92; 1.03) for cannabis use disorder). Sensitivity analyses to address pleiotropy and weak instrument bias yielded similar estimates to the primary analysis. In conclusion, our results do not support a causal association between cannabis use and POAG. |
| first_indexed | 2024-03-11T11:04:34Z |
| format | Article |
| id | doaj.art-a2316aa4d79d4376939ba5cc558b8b48 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T11:04:34Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a2316aa4d79d4376939ba5cc558b8b482023-11-12T12:18:31ZengNature PortfolioScientific Reports2045-23222023-11-011311710.1038/s41598-023-45872-zCannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization studyAndreas Katsimpris0Sebastian-Edgar Baumeister1Hansjörg Baurecht2Andrew J. Tatham3Michael Nolde4Princess Alexandra Eye PavilionInstitute of Health Services Research in Dentistry, University of MünsterDepartment of Epidemiology and Preventive Medicine, University of RegensburgPrincess Alexandra Eye PavilionInstitute of Health Services Research in Dentistry, University of MünsterAbstract Several observational studies have investigated the association between cannabis use and intraocular pressure, but its association with primary open-angle glaucoma (POAG) remains unclear. In this study, we leveraged human genetic data to assess through Mendelian randomization (MR) whether cannabis use affects POAG. We used five single-nucleotide polymorphisms (SNPs) associated with lifetime cannabis use (P-value < 5 × 10–8) from a genome-wide association study (GWAS) (N = 184,765) by the International Cannabis Consortium, 23andMe, and UK Biobank and eleven SNPs associated with cannabis use disorder (P-value < 5 × 10–7) from a GWAS meta-analysis of (17,068 cases and 357,219 controls of European descent) from Psychiatric Genomics Consortium Substance Use Disorders working group, Lundbeck Foundation Initiative for Integrative Psychiatric Research, and deCode. We associated the selected five SNPs from the GWAS of lifetime cannabis use and the eleven SNPs from the GWAS of cannabis use disorder, with the largest to date GWAS meta-analysis of POAG (16,677 cases and 199,580 controls). MR analysis suggested no evidence for a causal association of lifetime cannabis use and cannabis use disorder with POAG (odds ratio (OR) of outcome per doubling of the odds of exposure (95% confidence interval): 1.04 (0.88; 1.23) for lifetime cannabis use and 0.97 (0.92; 1.03) for cannabis use disorder). Sensitivity analyses to address pleiotropy and weak instrument bias yielded similar estimates to the primary analysis. In conclusion, our results do not support a causal association between cannabis use and POAG.https://doi.org/10.1038/s41598-023-45872-z |
| spellingShingle | Andreas Katsimpris Sebastian-Edgar Baumeister Hansjörg Baurecht Andrew J. Tatham Michael Nolde Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study Scientific Reports |
| title | Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study |
| title_full | Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study |
| title_fullStr | Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study |
| title_full_unstemmed | Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study |
| title_short | Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study |
| title_sort | cannabis use and the risk of primary open angle glaucoma a mendelian randomization study |
| url | https://doi.org/10.1038/s41598-023-45872-z |
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