Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease

Upregulated Fcrl5 disrupts B cell anergy and causes autoimmune disease

B cell anergy plays a critical role in maintaining self-tolerance by inhibiting autoreactive B cell activation to prevent autoimmune diseases. Here, we demonstrated that Fc receptor-like 5 (Fcrl5) upregulation contributes to autoimmune disease pathogenesis by disrupting B cell anergy. Fcrl5—a gene w...

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Bibliographic Details
Main Authors: Chisato Ono, Shinya Tanaka, Keiko Myouzen, Takeshi Iwasaki, Mahoko Ueda, Yoshinao Oda, Kazuhiko Yamamoto, Yuta Kochi, Yoshihiro Baba
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
Fc receptor-like 5 (Fcrl5)
B cells
age/autoimmunity-associated B cells
autoimmunity
immune tolerance
anergy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276014/full

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