Between Scylla and Charybdis: thrombosis in children with hemophilia
Thromboembolism is an infrequent complication in children with hemophilia that has been traditionally associated with the presence of a central venous access device. Novel rebalancing agents have shown promising results as prophylactic therapies to minimize the risk of bleeding but both thromboembol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1173549/full |
| _version_ | 1797822006083715072 |
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| author | Jad El Maamari Ali Amid Marie-Claude Pelland-Marcotte Marie-Claude Pelland-Marcotte Soumitra Tole Soumitra Tole |
| author_facet | Jad El Maamari Ali Amid Marie-Claude Pelland-Marcotte Marie-Claude Pelland-Marcotte Soumitra Tole Soumitra Tole |
| author_sort | Jad El Maamari |
| collection | DOAJ |
| description | Thromboembolism is an infrequent complication in children with hemophilia that has been traditionally associated with the presence of a central venous access device. Novel rebalancing agents have shown promising results as prophylactic therapies to minimize the risk of bleeding but both thromboembolism and thrombotic microangiopathy have been reported as complications. The management of thrombosis in children with hemophilia is particularly challenging given the inherent risk of bleeding. In this paper, we present clinical vignettes to review the literature, highlight challenges, and describe our approach to managing thromboembolism in children with hemophilia. |
| first_indexed | 2024-03-13T10:02:23Z |
| format | Article |
| id | doaj.art-a234e546cccc454e820a9cd774b34352 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-13T10:02:23Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-a234e546cccc454e820a9cd774b343522023-05-23T04:57:23ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-05-011110.3389/fped.2023.11735491173549Between Scylla and Charybdis: thrombosis in children with hemophiliaJad El Maamari0Ali Amid1Marie-Claude Pelland-Marcotte2Marie-Claude Pelland-Marcotte3Soumitra Tole4Soumitra Tole5Division of Pediatric Hematology/Oncology, Department of Pediatrics, BC Children’s Hospital, Vancouver, BC, CanadaDivision of Pediatric Hematology/Oncology, Department of Pediatrics, BC Children’s Hospital, Vancouver, BC, CanadaDivision of Pediatric Hematology-Oncology, CHU deQuébec—Centre Mère-Enfant Soleil, Quebec City, QC, CanadaResearch Center of the CHU de Québec, Axe Reproduction, Santé de la Mère et de l’Enfant, Quebec City, CanadaDepartment of Pediatrics, Schulich School of Medicine & Dentistry, Western University, London, ON, CanadaDepartment of Pediatrics, Division of Hematology/Oncology, London Health Sciences Centre, London, ON, CanadaThromboembolism is an infrequent complication in children with hemophilia that has been traditionally associated with the presence of a central venous access device. Novel rebalancing agents have shown promising results as prophylactic therapies to minimize the risk of bleeding but both thromboembolism and thrombotic microangiopathy have been reported as complications. The management of thrombosis in children with hemophilia is particularly challenging given the inherent risk of bleeding. In this paper, we present clinical vignettes to review the literature, highlight challenges, and describe our approach to managing thromboembolism in children with hemophilia.https://www.frontiersin.org/articles/10.3389/fped.2023.1173549/fullhemophiliathrombosischildrenemicizumabCVAD |
| spellingShingle | Jad El Maamari Ali Amid Marie-Claude Pelland-Marcotte Marie-Claude Pelland-Marcotte Soumitra Tole Soumitra Tole Between Scylla and Charybdis: thrombosis in children with hemophilia Frontiers in Pediatrics hemophilia thrombosis children emicizumab CVAD |
| title | Between Scylla and Charybdis: thrombosis in children with hemophilia |
| title_full | Between Scylla and Charybdis: thrombosis in children with hemophilia |
| title_fullStr | Between Scylla and Charybdis: thrombosis in children with hemophilia |
| title_full_unstemmed | Between Scylla and Charybdis: thrombosis in children with hemophilia |
| title_short | Between Scylla and Charybdis: thrombosis in children with hemophilia |
| title_sort | between scylla and charybdis thrombosis in children with hemophilia |
| topic | hemophilia thrombosis children emicizumab CVAD |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1173549/full |
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