Parental risk factors for oesophageal atresia
Background: An Oesophageal atresia (OA) affects almost 1 in 3500 newborn and its aetiology for development between 4th to 6th pregnancy weeks had not yet been clarified. Methods: This retrospective, observational control group-supported (n = 30) examination was performed with OA mothers (n = 20) who...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664623000682 |
| _version_ | 1797745991692058624 |
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| author | Melanie Kapapa Daniela Weber Alexandre Serra |
| author_facet | Melanie Kapapa Daniela Weber Alexandre Serra |
| author_sort | Melanie Kapapa |
| collection | DOAJ |
| description | Background: An Oesophageal atresia (OA) affects almost 1 in 3500 newborn and its aetiology for development between 4th to 6th pregnancy weeks had not yet been clarified. Methods: This retrospective, observational control group-supported (n = 30) examination was performed with OA mothers (n = 20) who were interrogated via specialized questionnaires and interviews to evaluate data on medical pregnancy history including hormonal treatment, changing of life habits (nutrition, diet, medication), drug consumption (alcohol, smoking, illicit drugs) as well as exposure to nuclear waste or poisonous substance exposition. Aim was to assess risk factors during pregnancy and in particular in the first trimester. Results: The body mass index (BMI) prior pregnancy of OA mothers was significant lower (p = 0.022) and the number of mothers with obesity (BMI>30) did not differ to control group mothers (p = 0.081). They had additionally more pre-existing illnesses (p = 0.009) and allergies (p = 0.001). Control group mothers changed dietary habits with higher meat (p = 0.032) and caffeine intake (p = 0.012) compared to OA mothers, which had higher rates of abnormalities during pregnancy (p < 0.001) and 38.7% of them suffered of ≥1 abortion in the past. The ethnical background of OA mothers was more often German (p < 0.033), while OA fathers had a lower socioeconomic status (p = 0.039). Conclusion: Maternal factors like previous abortions, obesity and immunological predispositions like existence of allergies combined with increased daily dairy consumption influenced obviously the occurrence of OA. |
| first_indexed | 2024-03-12T15:31:42Z |
| format | Article |
| id | doaj.art-a236f19a9a114720b946bf7a237b0a89 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-03-12T15:31:42Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-a236f19a9a114720b946bf7a237b0a892023-08-10T04:33:46ZengElsevierJournal of the Formosan Medical Association0929-66462023-09-011229932939Parental risk factors for oesophageal atresiaMelanie Kapapa0Daniela Weber1Alexandre Serra2Corresponding author. Division of Pediatric Surgery, Department of Surgery, University Medical Centre Ulm, Eythstrasse 24, 89075 Ulm, Germany.; Division of Paediatric Surgery, Department of Surgery, University Medical Centre Ulm, Eythstrasse 24, 89075 Ulm, GermanyDivision of Paediatric Surgery, Department of Surgery, University Medical Centre Ulm, Eythstrasse 24, 89075 Ulm, GermanyDivision of Paediatric Surgery, Department of Surgery, University Medical Centre Ulm, Eythstrasse 24, 89075 Ulm, GermanyBackground: An Oesophageal atresia (OA) affects almost 1 in 3500 newborn and its aetiology for development between 4th to 6th pregnancy weeks had not yet been clarified. Methods: This retrospective, observational control group-supported (n = 30) examination was performed with OA mothers (n = 20) who were interrogated via specialized questionnaires and interviews to evaluate data on medical pregnancy history including hormonal treatment, changing of life habits (nutrition, diet, medication), drug consumption (alcohol, smoking, illicit drugs) as well as exposure to nuclear waste or poisonous substance exposition. Aim was to assess risk factors during pregnancy and in particular in the first trimester. Results: The body mass index (BMI) prior pregnancy of OA mothers was significant lower (p = 0.022) and the number of mothers with obesity (BMI>30) did not differ to control group mothers (p = 0.081). They had additionally more pre-existing illnesses (p = 0.009) and allergies (p = 0.001). Control group mothers changed dietary habits with higher meat (p = 0.032) and caffeine intake (p = 0.012) compared to OA mothers, which had higher rates of abnormalities during pregnancy (p < 0.001) and 38.7% of them suffered of ≥1 abortion in the past. The ethnical background of OA mothers was more often German (p < 0.033), while OA fathers had a lower socioeconomic status (p = 0.039). Conclusion: Maternal factors like previous abortions, obesity and immunological predispositions like existence of allergies combined with increased daily dairy consumption influenced obviously the occurrence of OA.http://www.sciencedirect.com/science/article/pii/S0929664623000682Oesophageal atresiaRiskAllergiesNutritionPolyhydramnios |
| spellingShingle | Melanie Kapapa Daniela Weber Alexandre Serra Parental risk factors for oesophageal atresia Journal of the Formosan Medical Association Oesophageal atresia Risk Allergies Nutrition Polyhydramnios |
| title | Parental risk factors for oesophageal atresia |
| title_full | Parental risk factors for oesophageal atresia |
| title_fullStr | Parental risk factors for oesophageal atresia |
| title_full_unstemmed | Parental risk factors for oesophageal atresia |
| title_short | Parental risk factors for oesophageal atresia |
| title_sort | parental risk factors for oesophageal atresia |
| topic | Oesophageal atresia Risk Allergies Nutrition Polyhydramnios |
| url | http://www.sciencedirect.com/science/article/pii/S0929664623000682 |
| work_keys_str_mv | AT melaniekapapa parentalriskfactorsforoesophagealatresia AT danielaweber parentalriskfactorsforoesophagealatresia AT alexandreserra parentalriskfactorsforoesophagealatresia |