The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016
ObjectivesTo access the dose-response relationship between sex hormones and hyperuricemia (HUA), and to find the cut-off value in different gender.Methods9,685 participants were derived from the database of National Health and Nutrition Examination Survey (NHANES). Restricted cubic spline (RCS) anal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1035114/full |
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| author | Guo-yun Li Guo-yun Li Guo-yun Li Xu-dong Qian Chun-ming Ma Fu-zai Yin Fu-zai Yin |
| author_facet | Guo-yun Li Guo-yun Li Guo-yun Li Xu-dong Qian Chun-ming Ma Fu-zai Yin Fu-zai Yin |
| author_sort | Guo-yun Li |
| collection | DOAJ |
| description | ObjectivesTo access the dose-response relationship between sex hormones and hyperuricemia (HUA), and to find the cut-off value in different gender.Methods9,685 participants were derived from the database of National Health and Nutrition Examination Survey (NHANES). Restricted cubic spline (RCS) analysis were applied to explore the relationship between sex hormones and HUA after adjusting for confounding factors by propensity score match (PSM). Logistic regression was used to estimate the odds ratio (OR) and 95% CI.ResultsThe prevalence of HUA was 15.13% in female participants and 22.30% in male participants. Logistic regression analysis showed that estradiol (E2) was independently associated with HUA for a P value of 0.003 and 0.01in female and male participants, respectively. Testosterone (T) was only independently associated with HUA in male participants (P<0.001) but not in female participants (P = 0.59). RCS analysis showed a dose-response relationship between sex hormones and HUA. The risk of HUA increased as E2 lower than 29.6pg/mL in female participants and T lower than 389.1ng/dL in male participants. E2 higher than 23.6pg/ml was an independent risk factor for HUA in male participants.ConclusionA dose-response relationship was found between sex hormones and HUA. The cut-off value of E2 in male and female participants was 29.6pg/mL and 23.6pg/mL, respectively, and the cut-off value of T in male participants was 389.1ng/dL. These results provide a reference for preventing HUA and hormone supplement therapy. |
| first_indexed | 2024-04-12T14:55:30Z |
| format | Article |
| id | doaj.art-a23729f30dbb4496b6b9809be81efaf3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T14:55:30Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-a23729f30dbb4496b6b9809be81efaf32022-12-22T03:28:15ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10351141035114The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016Guo-yun Li0Guo-yun Li1Guo-yun Li2Xu-dong Qian3Chun-ming Ma4Fu-zai Yin5Fu-zai Yin6Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, ChinaDepartment of Endocrinology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, ChinaDepartment of Neurology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, ChinaDepartment of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, ChinaDepartment of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, ChinaDepartment of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, ChinaObjectivesTo access the dose-response relationship between sex hormones and hyperuricemia (HUA), and to find the cut-off value in different gender.Methods9,685 participants were derived from the database of National Health and Nutrition Examination Survey (NHANES). Restricted cubic spline (RCS) analysis were applied to explore the relationship between sex hormones and HUA after adjusting for confounding factors by propensity score match (PSM). Logistic regression was used to estimate the odds ratio (OR) and 95% CI.ResultsThe prevalence of HUA was 15.13% in female participants and 22.30% in male participants. Logistic regression analysis showed that estradiol (E2) was independently associated with HUA for a P value of 0.003 and 0.01in female and male participants, respectively. Testosterone (T) was only independently associated with HUA in male participants (P<0.001) but not in female participants (P = 0.59). RCS analysis showed a dose-response relationship between sex hormones and HUA. The risk of HUA increased as E2 lower than 29.6pg/mL in female participants and T lower than 389.1ng/dL in male participants. E2 higher than 23.6pg/ml was an independent risk factor for HUA in male participants.ConclusionA dose-response relationship was found between sex hormones and HUA. The cut-off value of E2 in male and female participants was 29.6pg/mL and 23.6pg/mL, respectively, and the cut-off value of T in male participants was 389.1ng/dL. These results provide a reference for preventing HUA and hormone supplement therapy.https://www.frontiersin.org/articles/10.3389/fendo.2022.1035114/fullhyperuricemiaestradioltestosteroneNHANESdose-response |
| spellingShingle | Guo-yun Li Guo-yun Li Guo-yun Li Xu-dong Qian Chun-ming Ma Fu-zai Yin Fu-zai Yin The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016 Frontiers in Endocrinology hyperuricemia estradiol testosterone NHANES dose-response |
| title | The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016 |
| title_full | The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016 |
| title_fullStr | The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016 |
| title_full_unstemmed | The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016 |
| title_short | The dose-response relationship between sex hormones and hyperuricemia in different gender: NHANES 2013-2016 |
| title_sort | dose response relationship between sex hormones and hyperuricemia in different gender nhanes 2013 2016 |
| topic | hyperuricemia estradiol testosterone NHANES dose-response |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1035114/full |
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