Kidney and urogenital abnormalities in Down syndrome: a meta-analysis
Abstract Background Reviews on Down syndrome do not or only marginally address the issue of kidney and urogenital tract abnormalities, and lower urinary tract dysfunctions. Hence, we performed a meta-analysis of the literature. Methods A literature search was undertaken in the Library of Medicine,...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-024-01636-7 |
| _version_ | 1827277045368881152 |
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| author | Caterina Maria Rossetti Giacomo D. Simonetti Mario G. Bianchetti Sebastiano A. G. Lava Giorgio Treglia Carlo Agostoni Gregorio P. Milani J. Peter de Winter |
| author_facet | Caterina Maria Rossetti Giacomo D. Simonetti Mario G. Bianchetti Sebastiano A. G. Lava Giorgio Treglia Carlo Agostoni Gregorio P. Milani J. Peter de Winter |
| author_sort | Caterina Maria Rossetti |
| collection | DOAJ |
| description | Abstract Background Reviews on Down syndrome do not or only marginally address the issue of kidney and urogenital tract abnormalities, and lower urinary tract dysfunctions. Hence, we performed a meta-analysis of the literature. Methods A literature search was undertaken in the Library of Medicine, Web of Science and Excerpta Medica. The search algorithm combined various keywords: (Down syndrome OR trisomy 21 OR mongolism) AND (kidney OR urinary tract OR bladder) AND (malformation OR dysfunction OR anomaly OR abnormality OR size). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was used. Results Eight case-control studies were retained for the final analysis. Three studies addressed the prevalence of kidney and urogenital tract abnormalities: an increased pooled relative risk of 5.49 (95%-CI: 1.78–16.93) was observed in Down syndrome. Penile malformations, obstructive malformations (including urethral valves), dilated urinary tract system, and kidney hypodysplasia were especially common. Three reports addressed the prevalence of lower urinary tract dysfunction: an increased pooled relative risk of 2.95 (95%-CI: 1.15–7.56) was observed. Finally, an autoptic study and an ultrasound study disclosed a reduced kidney size in Down syndrome. Conclusions This meta-analysis indicates that abnormalities of the kidney and urogenital tract, lower urinary tract dysfunctions, and a reduced kidney size present with an increased frequency in individuals with Down syndrome. |
| first_indexed | 2024-04-24T07:13:14Z |
| format | Article |
| id | doaj.art-a237cd8583524d718d985b9e4dcf05c9 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-04-24T07:13:14Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-a237cd8583524d718d985b9e4dcf05c92024-04-21T11:25:27ZengBMCItalian Journal of Pediatrics1824-72882024-04-015011710.1186/s13052-024-01636-7Kidney and urogenital abnormalities in Down syndrome: a meta-analysisCaterina Maria Rossetti0Giacomo D. Simonetti1Mario G. Bianchetti2Sebastiano A. G. Lava3Giorgio Treglia4Carlo Agostoni5Gregorio P. Milani6J. Peter de Winter7Pediatric Institute of Southern Switzerland, Ente Ospedaliero CantonalePediatric Institute of Southern Switzerland, Ente Ospedaliero CantonalePediatric Institute of Southern Switzerland, Ente Ospedaliero CantonalePediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of LausanneFaculty of Biomedical Sciences, Università della Svizzera ItalianaPediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoPediatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoDepartment of Development and RegenerationAbstract Background Reviews on Down syndrome do not or only marginally address the issue of kidney and urogenital tract abnormalities, and lower urinary tract dysfunctions. Hence, we performed a meta-analysis of the literature. Methods A literature search was undertaken in the Library of Medicine, Web of Science and Excerpta Medica. The search algorithm combined various keywords: (Down syndrome OR trisomy 21 OR mongolism) AND (kidney OR urinary tract OR bladder) AND (malformation OR dysfunction OR anomaly OR abnormality OR size). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was used. Results Eight case-control studies were retained for the final analysis. Three studies addressed the prevalence of kidney and urogenital tract abnormalities: an increased pooled relative risk of 5.49 (95%-CI: 1.78–16.93) was observed in Down syndrome. Penile malformations, obstructive malformations (including urethral valves), dilated urinary tract system, and kidney hypodysplasia were especially common. Three reports addressed the prevalence of lower urinary tract dysfunction: an increased pooled relative risk of 2.95 (95%-CI: 1.15–7.56) was observed. Finally, an autoptic study and an ultrasound study disclosed a reduced kidney size in Down syndrome. Conclusions This meta-analysis indicates that abnormalities of the kidney and urogenital tract, lower urinary tract dysfunctions, and a reduced kidney size present with an increased frequency in individuals with Down syndrome.https://doi.org/10.1186/s13052-024-01636-7Down syndromeKidney sizeUrogenital abnormalitiesDysfunction of the urinary bladderMeta-analysis |
| spellingShingle | Caterina Maria Rossetti Giacomo D. Simonetti Mario G. Bianchetti Sebastiano A. G. Lava Giorgio Treglia Carlo Agostoni Gregorio P. Milani J. Peter de Winter Kidney and urogenital abnormalities in Down syndrome: a meta-analysis Italian Journal of Pediatrics Down syndrome Kidney size Urogenital abnormalities Dysfunction of the urinary bladder Meta-analysis |
| title | Kidney and urogenital abnormalities in Down syndrome: a meta-analysis |
| title_full | Kidney and urogenital abnormalities in Down syndrome: a meta-analysis |
| title_fullStr | Kidney and urogenital abnormalities in Down syndrome: a meta-analysis |
| title_full_unstemmed | Kidney and urogenital abnormalities in Down syndrome: a meta-analysis |
| title_short | Kidney and urogenital abnormalities in Down syndrome: a meta-analysis |
| title_sort | kidney and urogenital abnormalities in down syndrome a meta analysis |
| topic | Down syndrome Kidney size Urogenital abnormalities Dysfunction of the urinary bladder Meta-analysis |
| url | https://doi.org/10.1186/s13052-024-01636-7 |
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