Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma
Keratinocyte skin cancer, consisting of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is by far the most common cancer in white-skinned populations, with rapid increases over the last 50 years. While the age-standardized incidence rates increase worldwide, the age-standardized mortal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/3/606 |
| _version_ | 1797318952967208960 |
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| author | Lena Nanz Ulrike Keim Alexander Katalinic Thomas Meyer Claus Garbe Ulrike Leiter |
| author_facet | Lena Nanz Ulrike Keim Alexander Katalinic Thomas Meyer Claus Garbe Ulrike Leiter |
| author_sort | Lena Nanz |
| collection | DOAJ |
| description | Keratinocyte skin cancer, consisting of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is by far the most common cancer in white-skinned populations, with rapid increases over the last 50 years. While the age-standardized incidence rates increase worldwide, the age-standardized mortality rates are variable. The incidence rates of keratinocyte skin cancer are much higher compared to those of melanoma, and are largely attributed to the raising exposure to ultraviolet (UV) radiation, the most important causal risk factor for skin cancer. Whereas the development of BCC is mainly due to intense UV exposure during childhood and adolescence, the development of SCC is related to chronic, cumulative UV exposure over decades. Although mortality rates are relatively low, SCC is an increasing problem for healthcare services, significantly causing morbidity, especially in older age groups. This review reports on the epidemiology of keratinocyte skin cancer, with a focus on SCC, in Australia, the United States, and the north of Europe, with an outlook on further challenges health systems will be confronted with in the next 20 years. |
| first_indexed | 2024-03-08T03:59:50Z |
| format | Article |
| id | doaj.art-a2380378494e4cdda88a7b4589a6268d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T03:59:50Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a2380378494e4cdda88a7b4589a6268d2024-02-09T15:09:18ZengMDPI AGCancers2072-66942024-01-0116360610.3390/cancers16030606Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell CarcinomaLena Nanz0Ulrike Keim1Alexander Katalinic2Thomas Meyer3Claus Garbe4Ulrike Leiter5Center for Dermatooncology, Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, GermanyCenter for Dermatooncology, Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, GermanyInstitute for Social Medicine and Epidemiology, University of Lübeck, Maria-Göppert-Str. 22, 23562 Lübeck, GermanyDepartment of Dermatology, Venerology, and Allergology, University of Bochum, Gudrunstr. 56, 44791 Bochum, GermanyCenter for Dermatooncology, Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, GermanyCenter for Dermatooncology, Department of Dermatology, University of Tübingen, Liebermeisterstr. 25, 72076 Tübingen, GermanyKeratinocyte skin cancer, consisting of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), is by far the most common cancer in white-skinned populations, with rapid increases over the last 50 years. While the age-standardized incidence rates increase worldwide, the age-standardized mortality rates are variable. The incidence rates of keratinocyte skin cancer are much higher compared to those of melanoma, and are largely attributed to the raising exposure to ultraviolet (UV) radiation, the most important causal risk factor for skin cancer. Whereas the development of BCC is mainly due to intense UV exposure during childhood and adolescence, the development of SCC is related to chronic, cumulative UV exposure over decades. Although mortality rates are relatively low, SCC is an increasing problem for healthcare services, significantly causing morbidity, especially in older age groups. This review reports on the epidemiology of keratinocyte skin cancer, with a focus on SCC, in Australia, the United States, and the north of Europe, with an outlook on further challenges health systems will be confronted with in the next 20 years.https://www.mdpi.com/2072-6694/16/3/606incidencemortalitykeratinocyte skin cancercutaneous squamous cell carcinoma |
| spellingShingle | Lena Nanz Ulrike Keim Alexander Katalinic Thomas Meyer Claus Garbe Ulrike Leiter Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma Cancers incidence mortality keratinocyte skin cancer cutaneous squamous cell carcinoma |
| title | Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma |
| title_full | Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma |
| title_fullStr | Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma |
| title_full_unstemmed | Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma |
| title_short | Epidemiology of Keratinocyte Skin Cancer with a Focus on Cutaneous Squamous Cell Carcinoma |
| title_sort | epidemiology of keratinocyte skin cancer with a focus on cutaneous squamous cell carcinoma |
| topic | incidence mortality keratinocyte skin cancer cutaneous squamous cell carcinoma |
| url | https://www.mdpi.com/2072-6694/16/3/606 |
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