Association of Periodontitis and Aging-Related Diseases: A Review of Mechanistic Studies
Background and Aim: Periodontitis, as the most prevalent cause of tooth loss, affects 20-50% of individuals throughout the world. One factor involved in the severity and incidence of periodontitis is aging, which is a substantial risk factor for mortality and morbidity. It is stated that some disord...
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| Format: | Article |
| Language: | English |
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Islamic Azad University
2023-01-01
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| Series: | Journal of Research in Dental and Maxillofacial Sciences |
| Subjects: | |
| Online Access: | http://jrdms.dentaliau.ac.ir/article-1-397-en.html |
| _version_ | 1797943590735839232 |
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| author | M Gholami SM Asadinejad D Kakavand P Jafari Doudaran AH Fathi |
| author_facet | M Gholami SM Asadinejad D Kakavand P Jafari Doudaran AH Fathi |
| author_sort | M Gholami |
| collection | DOAJ |
| description | Background and Aim: Periodontitis, as the most prevalent cause of tooth loss, affects 20-50% of individuals throughout the world. One factor involved in the severity and incidence of periodontitis is aging, which is a substantial risk factor for mortality and morbidity. It is stated that some disorders are common in older population, like cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease. Understanding the changes related to aging may provide a better insight into age-related diseases. Hence, this study aimed to review and summarize evidence regarding periodontitis and aging-related disorders with a mechanistic insight.
Materials and Methods: Data were obtained from the scientific databases, including PubMed, Google Scholar, and Scopus in English between 1993 and 2021.
Results: Cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease are associated with periodontitis directly or indirectly, and pro-inflammatory cytokines are the key mediators in such relationships. For instance, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), and IL-6 have a substantial role in pathogenesis of periodontitis in the majority of such diseases. These agents, particularly IL-1β and TNF-α, can also lead to leukocyte migration and subsequently form reactive oxygen species (ROS), reactive nitrogen species, and matrix metalloproteinases (MMPs).
Conclusion: It seems that periodontitis is linked to aging-related diseases, namely cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease by the mediation of pro-inflammatory agents such as IL-1β, TNF-α, and IL-6. |
| first_indexed | 2024-04-10T20:25:34Z |
| format | Article |
| id | doaj.art-a239e32b36a0486699f295596bb2a64b |
| institution | Directory Open Access Journal |
| issn | 2383-2754 |
| language | English |
| last_indexed | 2024-04-10T20:25:34Z |
| publishDate | 2023-01-01 |
| publisher | Islamic Azad University |
| record_format | Article |
| series | Journal of Research in Dental and Maxillofacial Sciences |
| spelling | doaj.art-a239e32b36a0486699f295596bb2a64b2023-01-25T11:15:05ZengIslamic Azad UniversityJournal of Research in Dental and Maxillofacial Sciences2383-27542023-01-01816270Association of Periodontitis and Aging-Related Diseases: A Review of Mechanistic StudiesM Gholami0SM Asadinejad1D Kakavand2P Jafari Doudaran3AH Fathi4 Department of Periodontics, Shiraz University of Medical Sciences, Shiraz, Iran Department of Periodontics, School of Dentistry, Isfahan University of Medi-cal Sciences, Isfahan, Iran Dental Clinic, Mazandaran University of Medical Sciences, Sari, Iran Student Research Committee, Qom University of Medical Sciences, Qom, Iran Dental Material Research Center and Department of Prosthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran Background and Aim: Periodontitis, as the most prevalent cause of tooth loss, affects 20-50% of individuals throughout the world. One factor involved in the severity and incidence of periodontitis is aging, which is a substantial risk factor for mortality and morbidity. It is stated that some disorders are common in older population, like cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease. Understanding the changes related to aging may provide a better insight into age-related diseases. Hence, this study aimed to review and summarize evidence regarding periodontitis and aging-related disorders with a mechanistic insight. Materials and Methods: Data were obtained from the scientific databases, including PubMed, Google Scholar, and Scopus in English between 1993 and 2021. Results: Cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease are associated with periodontitis directly or indirectly, and pro-inflammatory cytokines are the key mediators in such relationships. For instance, interleukin (IL)-1β, tumor necrosis factor-α (TNF-α), and IL-6 have a substantial role in pathogenesis of periodontitis in the majority of such diseases. These agents, particularly IL-1β and TNF-α, can also lead to leukocyte migration and subsequently form reactive oxygen species (ROS), reactive nitrogen species, and matrix metalloproteinases (MMPs). Conclusion: It seems that periodontitis is linked to aging-related diseases, namely cardiovascular diseases, osteoporosis, chronic kidney disease, and Alzheimer’s disease by the mediation of pro-inflammatory agents such as IL-1β, TNF-α, and IL-6.http://jrdms.dentaliau.ac.ir/article-1-397-en.htmlalzheimer’s diseaserenal failureosteoporosiscardiovascular diseasesperiodontitis |
| spellingShingle | M Gholami SM Asadinejad D Kakavand P Jafari Doudaran AH Fathi Association of Periodontitis and Aging-Related Diseases: A Review of Mechanistic Studies Journal of Research in Dental and Maxillofacial Sciences alzheimer’s disease renal failure osteoporosis cardiovascular diseases periodontitis |
| title | Association of Periodontitis and Aging-Related
Diseases: A Review of Mechanistic Studies |
| title_full | Association of Periodontitis and Aging-Related
Diseases: A Review of Mechanistic Studies |
| title_fullStr | Association of Periodontitis and Aging-Related
Diseases: A Review of Mechanistic Studies |
| title_full_unstemmed | Association of Periodontitis and Aging-Related
Diseases: A Review of Mechanistic Studies |
| title_short | Association of Periodontitis and Aging-Related
Diseases: A Review of Mechanistic Studies |
| title_sort | association of periodontitis and aging related diseases a review of mechanistic studies |
| topic | alzheimer’s disease renal failure osteoporosis cardiovascular diseases periodontitis |
| url | http://jrdms.dentaliau.ac.ir/article-1-397-en.html |
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