Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s disease
Abstract This study aimed to investigate the effects of early-stage Alzheimer’s disease (AD) on the reach-to-grasp kinematics and kinetics with and without visual supervision of the grasping arm and hand. Seventeen patients who had been diagnosed with early-stage AD and 17 age- and gender-matched, c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Journal of NeuroEngineering and Rehabilitation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12984-022-01108-1 |
| _version_ | 1811225082045923328 |
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| author | Jianhong Zhang Yunling Xiao Zong-Ming Li Na Wei Leitong Lin Ke Li |
| author_facet | Jianhong Zhang Yunling Xiao Zong-Ming Li Na Wei Leitong Lin Ke Li |
| author_sort | Jianhong Zhang |
| collection | DOAJ |
| description | Abstract This study aimed to investigate the effects of early-stage Alzheimer’s disease (AD) on the reach-to-grasp kinematics and kinetics with and without visual supervision of the grasping arm and hand. Seventeen patients who had been diagnosed with early-stage AD and 17 age- and gender-matched, cognitive normal (CN) adults participated in the experiment. A mirror operating system was designed to block the visual feedback of their grasping hand and forearms but to virtually show grasped targets. The target for reach-to-grasp kinematics was a reflective marker installed on a base; and the target for reach-to-grasp kinetics was a custom-made apparatus installed with two six-component force/torque transducers. Kinematics and kinetic parameters were used to quantify the reach-to-grasp performances. Results showed that the early-stage AD remarkably decreased the reaching speed, reduced the grasping accuracy and increased the transportation variability for reach-to-grasp kinematics. For kinetic analysis, early-stage AD extended the preload duration, disturbed the grip and lift forces coordination, and increased the feedforward proportion in the grasping force control. The AD-related changes in the reach-to-grasp kinematic and kinetic parameters depended on visual feedback and were associated with nervous system function according to correlation analyses with the neuropsychological testing. These results suggest that the abnormal kinematic and kinetic characteristics may correlate with the neuropsychological status of early-stage AD, and that the reach-to-grasp kinematic and kinetic maneuver could potentially be used as a novel tool for non-invasive screening or evaluation of early-stage AD. |
| first_indexed | 2024-04-12T09:00:49Z |
| format | Article |
| id | doaj.art-a239edfeb85b412a94d825f754e8c69b |
| institution | Directory Open Access Journal |
| issn | 1743-0003 |
| language | English |
| last_indexed | 2024-04-12T09:00:49Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of NeuroEngineering and Rehabilitation |
| spelling | doaj.art-a239edfeb85b412a94d825f754e8c69b2022-12-22T03:39:15ZengBMCJournal of NeuroEngineering and Rehabilitation1743-00032022-11-0119111510.1186/s12984-022-01108-1Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s diseaseJianhong Zhang0Yunling Xiao1Zong-Ming Li2Na Wei3Leitong Lin4Ke Li5School of Control Science and Engineering, Shandong UniversityDepartment of Geriatrics, Qilu Hospital, Shandong UniversityDepartment of Orthopaedic Surgery, University of ArizonaDepartment of Geriatrics, Qilu Hospital, Shandong UniversitySchool of Control Science and Engineering, Shandong UniversitySchool of Control Science and Engineering, Shandong UniversityAbstract This study aimed to investigate the effects of early-stage Alzheimer’s disease (AD) on the reach-to-grasp kinematics and kinetics with and without visual supervision of the grasping arm and hand. Seventeen patients who had been diagnosed with early-stage AD and 17 age- and gender-matched, cognitive normal (CN) adults participated in the experiment. A mirror operating system was designed to block the visual feedback of their grasping hand and forearms but to virtually show grasped targets. The target for reach-to-grasp kinematics was a reflective marker installed on a base; and the target for reach-to-grasp kinetics was a custom-made apparatus installed with two six-component force/torque transducers. Kinematics and kinetic parameters were used to quantify the reach-to-grasp performances. Results showed that the early-stage AD remarkably decreased the reaching speed, reduced the grasping accuracy and increased the transportation variability for reach-to-grasp kinematics. For kinetic analysis, early-stage AD extended the preload duration, disturbed the grip and lift forces coordination, and increased the feedforward proportion in the grasping force control. The AD-related changes in the reach-to-grasp kinematic and kinetic parameters depended on visual feedback and were associated with nervous system function according to correlation analyses with the neuropsychological testing. These results suggest that the abnormal kinematic and kinetic characteristics may correlate with the neuropsychological status of early-stage AD, and that the reach-to-grasp kinematic and kinetic maneuver could potentially be used as a novel tool for non-invasive screening or evaluation of early-stage AD.https://doi.org/10.1186/s12984-022-01108-1Alzheimer’s diseaseSensorimotor controlReach-to-grasp performanceKinematicsKinetics |
| spellingShingle | Jianhong Zhang Yunling Xiao Zong-Ming Li Na Wei Leitong Lin Ke Li Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s disease Journal of NeuroEngineering and Rehabilitation Alzheimer’s disease Sensorimotor control Reach-to-grasp performance Kinematics Kinetics |
| title | Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s disease |
| title_full | Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s disease |
| title_fullStr | Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s disease |
| title_full_unstemmed | Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s disease |
| title_short | Reach-to-grasp kinematics and kinetics with and without visual feedback in early-stage Alzheimer’s disease |
| title_sort | reach to grasp kinematics and kinetics with and without visual feedback in early stage alzheimer s disease |
| topic | Alzheimer’s disease Sensorimotor control Reach-to-grasp performance Kinematics Kinetics |
| url | https://doi.org/10.1186/s12984-022-01108-1 |
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