Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats
Background: Myocardial infarction is an acute condition of myocardial necrosis. So, this study aimed the effect of high intensity interval training with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression rats. Materials and Methods: 32 male rats were randomly d...
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Kashan University of Medical Sciences and Health Services
2022-08-01
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| Online Access: | http://feyz.kaums.ac.ir/article-1-4600-en.html |
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| author | Mojdeh Nadaf-Fahmideh Shahram Gholamrezaei Ramin Shabani |
| author_facet | Mojdeh Nadaf-Fahmideh Shahram Gholamrezaei Ramin Shabani |
| author_sort | Mojdeh Nadaf-Fahmideh |
| collection | DOAJ |
| description | Background: Myocardial infarction is an acute condition of myocardial necrosis. So, this study aimed the effect of high intensity interval training with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression rats.
Materials and Methods: 32 male rats were randomly divided into 4 groups of HIIT, supplement, control and HIIT with supplement training in the two groups of high intensity and HIIT with supplement included performing 8 weeks of 4-minute activity with an intensity of 85-90% VO2max. Curcumin was also used at 100 mg / kg. Mitochondrial PGC-1α and ERR-α gene expression was obtained by real-time PCR. Data were analyzed by ANOVA and Shapiro-Wilk at P≤0.05.
Results: One-way analysis of variance test showed a significant difference in the expression of mitochondrial cardiomyocyte PGC-1α and ERR-α genes in male myocardial infarction mice in the study groups (P=0.001). The results of Tukey test showed a significant increase in PGC-1α and ERR-α gene expression in the HIIT and HIIT groups with supplementation compared to the control and supplement groups (P=0.001). There was no significant difference between the control and complement groups.
Conclusion: The results of this study showed that interval training alone and in interaction with curcumin increases the expression of ERRα and PGC-1α in the heart tissue of male stroke model mice. It seems that interval training and consumption of curcumin can be considered a good way to increase mitochondrial biogenesis and improve heart function. |
| first_indexed | 2024-12-10T19:35:26Z |
| format | Article |
| id | doaj.art-a23b0448f82e43689ebb8eecefc1b755 |
| institution | Directory Open Access Journal |
| issn | 1029-7855 2008-9821 |
| language | fas |
| last_indexed | 2024-12-10T19:35:26Z |
| publishDate | 2022-08-01 |
| publisher | Kashan University of Medical Sciences and Health Services |
| record_format | Article |
| series | Fiyz̤ |
| spelling | doaj.art-a23b0448f82e43689ebb8eecefc1b7552022-12-22T01:36:09ZfasKashan University of Medical Sciences and Health ServicesFiyz̤1029-78552008-98212022-08-01263264272Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model ratsMojdeh Nadaf-Fahmideh 0Shahram Gholamrezaei1Ramin Shabani 2Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, I.R. Iran.Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, I.R. Iran.Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, I.R. Iran.Background: Myocardial infarction is an acute condition of myocardial necrosis. So, this study aimed the effect of high intensity interval training with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression rats. Materials and Methods: 32 male rats were randomly divided into 4 groups of HIIT, supplement, control and HIIT with supplement training in the two groups of high intensity and HIIT with supplement included performing 8 weeks of 4-minute activity with an intensity of 85-90% VO2max. Curcumin was also used at 100 mg / kg. Mitochondrial PGC-1α and ERR-α gene expression was obtained by real-time PCR. Data were analyzed by ANOVA and Shapiro-Wilk at P≤0.05. Results: One-way analysis of variance test showed a significant difference in the expression of mitochondrial cardiomyocyte PGC-1α and ERR-α genes in male myocardial infarction mice in the study groups (P=0.001). The results of Tukey test showed a significant increase in PGC-1α and ERR-α gene expression in the HIIT and HIIT groups with supplementation compared to the control and supplement groups (P=0.001). There was no significant difference between the control and complement groups. Conclusion: The results of this study showed that interval training alone and in interaction with curcumin increases the expression of ERRα and PGC-1α in the heart tissue of male stroke model mice. It seems that interval training and consumption of curcumin can be considered a good way to increase mitochondrial biogenesis and improve heart function.http://feyz.kaums.ac.ir/article-1-4600-en.htmlhigh intensity interval trainingcurcuminpgc-1αerr-α |
| spellingShingle | Mojdeh Nadaf-Fahmideh Shahram Gholamrezaei Ramin Shabani Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats Fiyz̤ high intensity interval training curcumin pgc-1α err-α |
| title | Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats |
| title_full | Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats |
| title_fullStr | Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats |
| title_full_unstemmed | Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats |
| title_short | Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats |
| title_sort | investigation the effect of high intensity interval training hiit with curcumin supplementation on mitochondrial cardiomyocyte pgc 1α and err α gene expression in male stroke model rats |
| topic | high intensity interval training curcumin pgc-1α err-α |
| url | http://feyz.kaums.ac.ir/article-1-4600-en.html |
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