Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysis
Background Chronic rhinosinusitis (CRS) is a persistent inflammation of the sinuses. As a result of long-term discomfort, patients may experience symptoms of common mental disorders such as anxiety and depression. This may affect the quality of life and disease progression. However, there is still u...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/3/e079273.full |
| _version_ | 1797260088654692352 |
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| author | Hui Li Yuqi Wu Yijie Fu Xinru Gong Hongli Fan Zhoutong Han TianMin Zhu |
| author_facet | Hui Li Yuqi Wu Yijie Fu Xinru Gong Hongli Fan Zhoutong Han TianMin Zhu |
| author_sort | Hui Li |
| collection | DOAJ |
| description | Background Chronic rhinosinusitis (CRS) is a persistent inflammation of the sinuses. As a result of long-term discomfort, patients may experience symptoms of common mental disorders such as anxiety and depression. This may affect the quality of life and disease progression. However, there is still uncertainty about the extent of the problem.Objective This meta-analysis aimed to determine the prevalence of depression and anxiety symptoms in patients with CRS.Search strategy We searched PubMed, Embase, Web of Science, Cochrane Library, and CBM databases for relevant studies published before 15 July 2022 in patients with CRS with concomitant depression and anxiety symptoms.Data collection and analysis Two authors independently performed screening and quality assessment using validated tools. Extraction of data using predefined standardised data collection spreadsheets. Heterogeneity and inconsistency were checked using the I² statistic.Results The meta-analysis included 32 articles involving 56 933 patients. The prevalence of depression and anxiety symptoms was estimated at 24.7% (95% CI, 21.3% to 28. 1%) and 29.7% (95% CI, 19.3% to 40.2%). Subgroup analysis revealed the following: (1) CRS without nasal polyps (CRSsNP): 26.2% (95% CI, 21.9% to 30.5%), CRS with nasal polyps(CRSwNP): 20% (95% CI, 15.9% to 24%); (2) Female patients: 36. 1% (95% CI, 25.3% to 46.9%), male patients: 24.3% (95% CI, 12. 1% to 36.6%); and (3) The average age≤50 years patients: 29.8% (95% CI, 21.3% to 38.2%), the average age>50 years patients: 22. 1% (95% CI, 17.1% to 27%).Conclusion A significant proportion of people with CRS have symptoms of depression and anxiety, and early screening for depression and anxiety in people with CRS is critical. And, more attention needs to be given to females and patients with CRSsNP during screening.PROSPERO registration number CRD42022345959). |
| first_indexed | 2024-04-24T23:19:46Z |
| format | Article |
| id | doaj.art-a23b4799ea684c45bd6f92eb10e58b60 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-24T23:19:46Z |
| publishDate | 2024-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-a23b4799ea684c45bd6f92eb10e58b602024-03-16T23:10:07ZengBMJ Publishing GroupBMJ Open2044-60552024-03-0114310.1136/bmjopen-2023-079273Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysisHui Li0Yuqi Wu1Yijie Fu2Xinru Gong3Hongli Fan4Zhoutong Han5TianMin Zhu611Clinical Research Centre, Qilu Pharmaceutical, Jinan, ChinaSchool of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Preclinical Medicine, Chengdu University, Chengdu, Sichuan, ChinaSchool of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaSchool of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaSchool of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaSchool of Rehabilitation and Health Preservation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaBackground Chronic rhinosinusitis (CRS) is a persistent inflammation of the sinuses. As a result of long-term discomfort, patients may experience symptoms of common mental disorders such as anxiety and depression. This may affect the quality of life and disease progression. However, there is still uncertainty about the extent of the problem.Objective This meta-analysis aimed to determine the prevalence of depression and anxiety symptoms in patients with CRS.Search strategy We searched PubMed, Embase, Web of Science, Cochrane Library, and CBM databases for relevant studies published before 15 July 2022 in patients with CRS with concomitant depression and anxiety symptoms.Data collection and analysis Two authors independently performed screening and quality assessment using validated tools. Extraction of data using predefined standardised data collection spreadsheets. Heterogeneity and inconsistency were checked using the I² statistic.Results The meta-analysis included 32 articles involving 56 933 patients. The prevalence of depression and anxiety symptoms was estimated at 24.7% (95% CI, 21.3% to 28. 1%) and 29.7% (95% CI, 19.3% to 40.2%). Subgroup analysis revealed the following: (1) CRS without nasal polyps (CRSsNP): 26.2% (95% CI, 21.9% to 30.5%), CRS with nasal polyps(CRSwNP): 20% (95% CI, 15.9% to 24%); (2) Female patients: 36. 1% (95% CI, 25.3% to 46.9%), male patients: 24.3% (95% CI, 12. 1% to 36.6%); and (3) The average age≤50 years patients: 29.8% (95% CI, 21.3% to 38.2%), the average age>50 years patients: 22. 1% (95% CI, 17.1% to 27%).Conclusion A significant proportion of people with CRS have symptoms of depression and anxiety, and early screening for depression and anxiety in people with CRS is critical. And, more attention needs to be given to females and patients with CRSsNP during screening.PROSPERO registration number CRD42022345959).https://bmjopen.bmj.com/content/14/3/e079273.full |
| spellingShingle | Hui Li Yuqi Wu Yijie Fu Xinru Gong Hongli Fan Zhoutong Han TianMin Zhu Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysis BMJ Open |
| title | Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysis |
| title_full | Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysis |
| title_fullStr | Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysis |
| title_short | Prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis: a systematic review and meta-analysis |
| title_sort | prevalence and predictors of depression and anxiety in patients with chronic rhinosinusitis a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/14/3/e079273.full |
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