Black phosphorus-enhanced injectable hydrogel for infected soft tissue healing
The misuse of antibiotics makes clinical treatment of soft tissue infection a huge challenge in prosthesis replacement. In this study, a black phosphorus (BP)-enhanced antibacterial injectable hydrogel (HAABP) was developed by the dynamic coordinative cross-linking among thiolated hyaluronic acid, s...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2023-03-01
|
| Series: | APL Bioengineering |
| Online Access: | http://dx.doi.org/10.1063/5.0121241 |
| _version_ | 1797772672099155968 |
|---|---|
| author | Yaochao Zhao Zhijie Chen Wenjun Shao Shu Yang Wenguo Cui Zhengwei Cai Liang Cheng Ruixin Lin |
| author_facet | Yaochao Zhao Zhijie Chen Wenjun Shao Shu Yang Wenguo Cui Zhengwei Cai Liang Cheng Ruixin Lin |
| author_sort | Yaochao Zhao |
| collection | DOAJ |
| description | The misuse of antibiotics makes clinical treatment of soft tissue infection a huge challenge in prosthesis replacement. In this study, a black phosphorus (BP)-enhanced antibacterial injectable hydrogel (HAABP) was developed by the dynamic coordinative cross-linking among thiolated hyaluronic acid, silver ion (Ag+), and BP. HAABP has been proven to possess typical porous structures, excellent injectability, and rapid self-healing properties. In addition, the shear modulus was positive correlative to the concentration of BP. In vitro, HAABP maintained good cytocompatibility and showed a highly efficient synergistic inhibitory effect on Staphylococcus aureus through the irradiation of near infrared light and the release of Ag+. In vivo, HAABP not only inhibited the persistent infection but also accelerated the deposition of collagen fibers and angiogenesis by down-regulating the inflammatory factor TNF-α in the infectious wound defect, thereby repairing the natural barrier of tissue. This study developed a BP-enhanced injectable hydrogel that provided a simple and efficient synergistic antibacterial strategy to treat soft tissue infections around prostheses. |
| first_indexed | 2024-03-12T21:54:21Z |
| format | Article |
| id | doaj.art-a23e6b96d34f40dca567eff0a851551f |
| institution | Directory Open Access Journal |
| issn | 2473-2877 |
| language | English |
| last_indexed | 2024-03-12T21:54:21Z |
| publishDate | 2023-03-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Bioengineering |
| spelling | doaj.art-a23e6b96d34f40dca567eff0a851551f2023-07-25T19:45:11ZengAIP Publishing LLCAPL Bioengineering2473-28772023-03-0171016103016103-1210.1063/5.0121241Black phosphorus-enhanced injectable hydrogel for infected soft tissue healingYaochao Zhao0Zhijie Chen1Wenjun Shao2Shu Yang3Wenguo Cui4Zhengwei Cai5Liang Cheng6Ruixin Lin7 Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, People's Republic of China Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, People's Republic of China Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, People's Republic of China Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaThe misuse of antibiotics makes clinical treatment of soft tissue infection a huge challenge in prosthesis replacement. In this study, a black phosphorus (BP)-enhanced antibacterial injectable hydrogel (HAABP) was developed by the dynamic coordinative cross-linking among thiolated hyaluronic acid, silver ion (Ag+), and BP. HAABP has been proven to possess typical porous structures, excellent injectability, and rapid self-healing properties. In addition, the shear modulus was positive correlative to the concentration of BP. In vitro, HAABP maintained good cytocompatibility and showed a highly efficient synergistic inhibitory effect on Staphylococcus aureus through the irradiation of near infrared light and the release of Ag+. In vivo, HAABP not only inhibited the persistent infection but also accelerated the deposition of collagen fibers and angiogenesis by down-regulating the inflammatory factor TNF-α in the infectious wound defect, thereby repairing the natural barrier of tissue. This study developed a BP-enhanced injectable hydrogel that provided a simple and efficient synergistic antibacterial strategy to treat soft tissue infections around prostheses.http://dx.doi.org/10.1063/5.0121241 |
| spellingShingle | Yaochao Zhao Zhijie Chen Wenjun Shao Shu Yang Wenguo Cui Zhengwei Cai Liang Cheng Ruixin Lin Black phosphorus-enhanced injectable hydrogel for infected soft tissue healing APL Bioengineering |
| title | Black phosphorus-enhanced injectable hydrogel for infected soft tissue healing |
| title_full | Black phosphorus-enhanced injectable hydrogel for infected soft tissue healing |
| title_fullStr | Black phosphorus-enhanced injectable hydrogel for infected soft tissue healing |
| title_full_unstemmed | Black phosphorus-enhanced injectable hydrogel for infected soft tissue healing |
| title_short | Black phosphorus-enhanced injectable hydrogel for infected soft tissue healing |
| title_sort | black phosphorus enhanced injectable hydrogel for infected soft tissue healing |
| url | http://dx.doi.org/10.1063/5.0121241 |
| work_keys_str_mv | AT yaochaozhao blackphosphorusenhancedinjectablehydrogelforinfectedsofttissuehealing AT zhijiechen blackphosphorusenhancedinjectablehydrogelforinfectedsofttissuehealing AT wenjunshao blackphosphorusenhancedinjectablehydrogelforinfectedsofttissuehealing AT shuyang blackphosphorusenhancedinjectablehydrogelforinfectedsofttissuehealing AT wenguocui blackphosphorusenhancedinjectablehydrogelforinfectedsofttissuehealing AT zhengweicai blackphosphorusenhancedinjectablehydrogelforinfectedsofttissuehealing AT liangcheng blackphosphorusenhancedinjectablehydrogelforinfectedsofttissuehealing AT ruixinlin blackphosphorusenhancedinjectablehydrogelforinfectedsofttissuehealing |